A5052586931- Acute Kidney Injury Research
- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
- Chronic Kidney Disease and Diabetes
- COVID-19 Clinical Research Studies
- Cystic Fibrosis Research Advances
- Sepsis Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Neonatal and Maternal Infections
- Neonatal Health and Biochemistry
- Drug-Induced Hepatotoxicity and Protection
- SARS-CoV-2 and COVID-19 Research
- Poisoning and overdose treatments
- Dialysis and Renal Disease Management
- Kidney Stones and Urolithiasis Treatments
- Streptococcal Infections and Treatments
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Pharmaceutical Economics and Policy
- Inflammatory mediators and NSAID effects
- Neonatal Respiratory Health Research
- Blood disorders and treatments
- Drug-Induced Adverse Reactions
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacovigilance and Adverse Drug Reactions
University of Liverpool
2011-2023
Alder Hey Children's Hospital
2018-2023
National Institute for Health Research
2021-2022
Alder Hey Children's NHS Foundation Trust
2010-2022
Public Health England
2021
University of Oxford
2021
University of Bristol
2021
OG Technologies (United States)
2021
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2021
National Health and Medical Research Council
2021
Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain.
C-reactive protein (CRP) is an acute-phase that increases 4-6 h after inflammatory trigger and peaks at 36-50 h. Levels decrease rapidly with the resolution of inflammation. CRP generally highly elevated in invasive bacterial infections often used as a marker A single level neither sensitive nor specific enough to identify all children serious infection. However, raised does suggest infection should further assessment needed. levels fail decrease, or continue rise, 48 antibiotic therapy...
Premature infants are frequently exposed to aminoglycoside antibiotics. Novel urinary biomarkers may provide a non-invasive means for the early identification of aminoglycoside-related proximal tubule renal toxicity, enable adjustment treatment and at risk long-term impairment. In this proof-of-concept study, urine samples were collected from 41 premature neonates (≤32 weeks gestation) least once per week, daily during courses gentamicin, 3 days afterwards. Significant increases observed in...
The aim of this study was to establish reference intervals in healthy children for two novel urinary biomarkers acute kidney injury, injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Urinary were determined samples from the UK (n = 120) USA 171) using both Meso Scale Discovery (MSD) Luminex-based analytical approaches. 95% each biomarker cohort are presented stratified by sex or ethnicity where necessary, age-related variability is explored quantile regression....
Abstract Aminoglycosides are commonly used for the treatment of pulmonary exacerbations in patients with cystic fibrosis (CF). However, they potentially nephrotoxic. This prospective observational cohort study aimed to investigate potential validity two urinary renal biomarkers, Kidney Injury Molecule-1 (KIM-1) and Neutrophil Gelatinase-associated Lipocalin (NGAL), identifying aminoglycoside-induced nephrotoxicity children CF. Children young adults up 20 years age a confirmed diagnosis CF...
Accurate quantification of blood creatinine is important to estimate the glomerular filtration rate. Existing techniques using liquid chromatography tandem mass spectrometry (LC-MS/MS) have a high accuracy and eliminate most interferences encountered in routine enzymatic Jaffé methods. However, they require laborious time-consuming sample treatment data acquisition. The aim this study develop fast simple method enable direct analysis whole with performance measures that are comparable...
Acute kidney injury (AKI), a common complication in paediatric intensive care units (PICU), is associated with increased morbidity and mortality. In this single centre, prospective, observational cohort study, neutrophil gelatinase-associated lipocalin urine (uNGAL) plasma (pNGAL) renal angina index (RAI), combinations of these markers, were assessed for their ability to predict severe (stage 2 or 3) AKI children young people admitted PICU. PICU had initial serial uNGAL pNGAL measurements,...
Aims Royal College of Paediatrics and Child Health subspecialist training in Paediatric Clinical Pharmacology Therapeutics has been delivered the UK for 20 years, but no specialist clinical services have set up previously. Methods Prospective audit service evaluation paediatric pharmacology pilot phase dedicated at a children's hospital. Results Pilot scheme (May–October 2019), then weekly (established June 2020). Service covers High Dependency Unit, inpatients with polypharmacy. The...
There has been a great deal of excitement regarding the potential benefits statins beyond their lipid-lowering effect, and repurposing them for other indications. In this commentary, we evaluate role in protecting kidneys, with focus on three areas: cardiac surgery, contrast-induced nephropathy, aminoglycoside-induced nephrotoxicity. Statins inhibit activity 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase order to reduce cholesterol synthesis, leading lower circulating concentrations...
Abstract The PROteKT study tested the hypothesis that rosuvastatin can inhibit aminoglycoside-induced nephrotoxicity in children with Cystic Fibrosis (CF). This open label, parallel group, randomised controlled trial recruited and young people aged 6 to 18 years CF at 13 paediatric treatment centres UK. Participants were equally either receive oral (10 mg once daily) or no intervention (control) throughout clinically indicated intravenous tobramycin. primary outcome was difference between...
Background: Mevalonic acid (MVA), as a product of 3-hydroxy-3-methylglutaryl coenzyme A reductase, represents potential multipurpose biomarker in health and disease. translational urinary MVA quantification method was developed, validated used to demonstrate the diurnal variation excretion rats healthy children. Methods: Urinary converted mevalonolactone at pH 2, extracted with ethyl acetate quantified by reversed-phase liquid chromatography–tandem mass spectrometry. Results: The assay had...
We were grateful to a number of people who contacted us about our article on how use C reactive protein (CRP).1 Abelian from Wrexham Maelor Hospital drew attention data plasma half-life, suggesting this was 19 hours in an adult2 rather than the previously quoted 4–7 hours.3 4 Emmerson asked if there robust support range non-infectious conditions cause rise CRP newborn period. Our had review by Hengst.5 therefore reviewed papers referenced review. Chiesa et al 6 showed that mean...