A5069243952- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Bacterial Identification and Susceptibility Testing
- Emergency and Acute Care Studies
- Traumatic Ocular and Foreign Body Injuries
- Enhanced Recovery After Surgery
- Facial Trauma and Fracture Management
- Neonatal Respiratory Health Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Gestational Diabetes Research and Management
- Vitamin D Research Studies
- Metabolomics and Mass Spectrometry Studies
- Pediatric health and respiratory diseases
- Gut microbiota and health
- Listeria monocytogenes in Food Safety
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Appendicitis Diagnosis and Management
- Yersinia bacterium, plague, ectoparasites research
- Tracheal and airway disorders
- Neonatal and Maternal Infections
- Thermal Regulation in Medicine
- Adrenal Hormones and Disorders
- Hip and Femur Fractures
- Colorectal Cancer Surgical Treatments
- Surgical Simulation and Training
University of Liverpool
2017-2025
Alder Hey Children's NHS Foundation Trust
2020-2024
Alder Hey Children's Hospital
2022
Biology of Infection
2020
Oxford University Hospitals NHS Trust
2015-2019
Merseytravel
2019
Churchill Hospital
2016-2018
University of Oxford
2017
Queen's University Belfast
2013-2014
BACKGROUND AND OBJECTIVES: The identification of life-threatening infection in febrile children presenting to the emergency department (ED) remains difficult. quick Sequential Organ Failure Assessment (qSOFA) was only derived for adult populations, implying an urgent need pediatric scores. We developed and validated a novel, adapted qSOFA score (Liverpool [LqSOFA]) compared its performance with qSOFA, Pediatric Early Warning Score (PEWS), National Institute Health Care Excellence (NICE)...
Sepsis is a life-threatening clinical condition responsible for approximately 11 million deaths worldwide. Rapid and accurate identification of pathogenic bacteria its antimicrobial susceptibility play critical role in reducing the morbidity mortality rates related to sepsis. Raman infrared spectroscopies have great potential be used as diagnostic tools rapid culture-free detection bacterial infections. Despite numerous reports using both methods analyse samples, there date no study...
Proof-of-concept study, highlighting the clinical diagnostic ability of FT-IR compared with MALDI-TOF MS, combined WGS.
Sepsis is a life-threatening condition arising from dysregulated host immune response to infection, leading substantial global health burden. The accurate identification of bacterial pathogens in sepsis essential for guiding effective antimicrobial therapy and optimising patient outcomes. Traditional culture-based typing methods present inherent limitations, necessitating the exploration alternative diagnostic approaches. This study reports successful application Fourier-transform infrared...
The first aim of this study was to assess 25-hydroxy vitamin D (25OHD) concentrations in women with type 1 diabetes (T1DM) during pregnancy, post-delivery and also foetal (cord blood) 25OHD examine relationships between these. second the investigate potential interactions maternal body mass index (BMI) status. A further glycosylated haemoglobin (HbA1c) throughout pregnancy.This an observational 52 pregnant controls without 65 T1DM a university teaching hospital. Maternal serum measured...
Acute kidney injury (AKI), a common complication in paediatric intensive care units (PICU), is associated with increased morbidity and mortality. In this single centre, prospective, observational cohort study, neutrophil gelatinase-associated lipocalin urine (uNGAL) plasma (pNGAL) renal angina index (RAI), combinations of these markers, were assessed for their ability to predict severe (stage 2 or 3) AKI children young people admitted PICU. PICU had initial serial uNGAL pNGAL measurements,...
Abstract Introduction Rapid detection and identification of pathogens antimicrobial susceptibility is essential for guiding appropriate therapy reducing morbidity mortality associated with sepsis. Objectives The metabolic response clinical isolates Klebsiella oxytoca exposed to different concentrations ciprofloxacin (the second generation quinolones antibiotics) were studied in order investigate underlying mechanisms resistance (AMR). Methods Metabolomics investigations performed using...
<h3>Aims</h3> Paediatric surgery is challenging and training in this area subspecialised including anaesthesia post operative care. The Royal College of Surgeons Standards Surgical care for Children, 2013 supports the 'provision closer to home' patients with access appropriate level Typically district general hospital (DGH) healthy over 4 years old. This was a significant change practice from specialised tertiary centre local hospitals when safe. coordinated through an effective Clinical...
<h3>Aims</h3> This study aimed to evaluate the implementation and long term outcomes of a daily safety briefing (SB) in 12 bed paediatric Intensive Care Unit from January 2014 December 2017. Potential issues adverse were discussed. <h3>Methods</h3> Data was extracted contemporaneous recorded SB proforma analysed by Microsoft Excel. Success multidisciplinary involvement examined through frequency, attendance at staff surveys. <h3>Results</h3> mean duration 6.05 min (SD 0.672, range 2–20)...
<h3>Aims</h3> Electric (e-)scooters are increasingly popular in the UK and there is a paucity of published evidence regarding injury patterns children. Such vehicles can travel at speeds up to 68 mph, lanes traffic present as major trauma or serious injuries well minor injuries. Rental e-scooters illegal under 16s private only be used on land but despite this, were increasing presentations our emergency department (ED). We performed prospective retrospective audit gather information about...
<h3>Aims</h3> Bronchopulmonary dysplasia (BPD) or neonatal chronic lung disease is the commonest adverse outcome in very premature neonates. BPD incidence increasing unlike other prematurity associated conditions and despite advances aetiological understanding. incurs substantial healthcare costs which extend beyond initial hospitalisation, such as home oxygen therapy, recurrent admissions pulmonary hypertension. This review compares service provision organisation across North West of...
<h3>Aims</h3> Early oral corticosteroid therapy is recommended in the treatment of acute asthma exacerbations children. BTS/SIGN guidelines recommend that children with severe symptoms viral induced wheeze (VIW) should still receive steroids, and it advisable moderately cases without a previous diagnosis asthma. A single dose dexamethasone has been shown to be non-inferior 3- or 5-day course prednisolone management better tolerability compliance. Following new local 2019, we audited...