Lakshmi Ranganathan

ORCID: 0000-0001-5486-5753
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About
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Research Areas
  • Obstructive Sleep Apnea Research
  • COVID-19 Clinical Research Studies
  • Respiratory Support and Mechanisms
  • Sepsis Diagnosis and Treatment
  • Nutrition and Health in Aging
  • Clinical Nutrition and Gastroenterology
  • Acute Ischemic Stroke Management
  • Cerebral Venous Sinus Thrombosis
  • COVID-19 and healthcare impacts
  • Hereditary Neurological Disorders
  • Neurological Disorders and Treatments
  • Emergency and Acute Care Studies
  • Antibiotic Use and Resistance
  • Infection Control in Healthcare
  • COVID-19 epidemiological studies
  • Abdominal Surgery and Complications
  • Epilepsy research and treatment
  • Nosocomial Infections in ICU
  • Sleep and related disorders
  • COVID-19 and Mental Health
  • Cardiac Arrest and Resuscitation
  • Metabolism and Genetic Disorders
  • Head and Neck Anomalies
  • Cervical and Thoracic Myelopathy
  • Autism Spectrum Disorder Research

Apollo Hospitals
2015-2024

Apollo Hospitals
2020-2024

Australian and New Zealand Intensive Care Society
2020

Monash University
2020

Chinese University of Hong Kong
2020

Madras Medical College
2015-2020

CARE Hospitals
2020

Alfred Health
2020

Simin Aysel Florescu Dragos Stanciu Mihaela Zaharia Alma Kosa Daniel Codreanu and 95 more Komal Fareed Aneela Kidwai Callum Kaye Amanda Coutts Lynn MacKay Charlotte Summers Petra Polgarova Neda Farahi Eleonore Fox David Sapsford Katherine Bongaerts Peter J Featherstone Anthony Ng Stephen McWilliam Daniel B. Hawcutt Laura Rad Laura O’Malley Jennifer Whitbread Dawn Jones Rachael Dore Paula Saunderson Olivia Kelsall Nicholas Cowley Laura Wild Jessica Thrush Hannah Wood Karen Austin Adrian Donnelly Martin Kelly Naoise Smyth Sinéad O’Kane Declan McClintock Majella Warnock Ryan Campbell Edmund McCallion Amine Azaiz Cyril Charron Mathieu Godement Guillaume Géri Antoine Vieillard‐Baron Paul D. R. Johnson Shirley McKenna Joanne Hanley Andrew Currie Barbara Allen Clare McGoldrick Moyra McMaster Ashwin Mani Meghena Mathew Revathi Kandeepan C. Vignesh Nagarajan Ramakrishnan Augustian James Evangeline Elvira Ramachandran Pratheema Suresh Babu Rabindrarajan Ebenezer Sarayu Krishnamoorthy Lakshmi Ranganathan Manisha Ganesan Madhu Shree Simone Piva Emanuele Focà Damiano Rizzoni Gianluca E.M. Boari Mattia Marchesi Magdalena Butler Keri-Anne Cowdrey Brittany L. Mason Melissa Woolett Eamon Duffy Yan Chen Hiromi Nakamuro Caroline O’Connor Lauren West Khaled El-Khawas Angus Richardson Dianne Hill Robert J. Commons Hussam Abdelkharim Manoj Saxena Margaret Muteithia Kelsey Dobell‐Brown Rajeev Jha Michael Kalogirou Christine Ellis Srinivas Murthy Aibhilin O’Connor Saranya Thurairatnam Dipak Mukherjee Agilan Kaliappan Mark Vertue Anne Nicholson Joanne Riches Gracie Maloney

Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.

10.1001/jama.2023.4480 article EN JAMA 2023-04-11
Simin Aysel Florescu Dragos Stanciu Mihaela Zaharia Alma Kosa Daniel Codreanu and 95 more Komal Fareed Aneela Kidwai Callum Kaye Amanda Coutts Lynn MacKay Charlotte Summers Petra Polgarova Neda Farahi Eleonore Fox David Sapsford Katherine Bongaerts Peter J Featherstone Anthony Ng Stephen McWilliam Daniel B. Hawcutt Laura Rad Laura O’Malley Jennifer Whitbread Dawn Jones Rachael Dore Paula Saunderson Olivia Kelsall Nicholas Cowley Laura Wild Jessica Thrush Hannah Wood Karen Austin Adrian Donnelly Martin Kelly Naoise Smyth Sinéad O’Kane Declan McClintock Majella Warnock Ryan Campbell Edmund McCallion Amine Azaiz Cyril Charron Mathieu Godement Guillaume Géri Antoine Vieillard-Baron Paul D. R. Johnson Shirley McKenna Joanne Hanley Andrew Currie Barbara Allen Clare McGoldrick Moyra McMaster Ashwin Mani Meghena Mathew Revathi Kandeepan C. Vignesh Nagarajan Ramakrishnan Augustian James Evangeline Elvira Pratheema Ramachandran Suresh Babu Rabindrarajan Ebenezer Sarayu Krishnamoorthy Lakshmi Ranganathan Manisha Ganesan Madhu Shree Simone Piva Emanuele Focà Damiano Rizzoni Gianluca E.M. Boari Mattia Marchesi Magdalena Butler Keri-Anne Cowdrey Brittany L. Mason Melissa Woolett Eamon Duffy Yan Chen Hiromi Nakamuro Caroline O’Connor Lauren West Khaled El-Khawas Angus Richardson Dianne Hill Robert J. Commons Hussam Abdelkharim Manoj Saxena Margaret Muteithia Kelsey Dobell‐Brown Rajeev Jha Michael Kalogirou Christine Ellis Srinivas Murthy Aibhilin O’Connor Saranya Thurairatnam Dipak Mukherjee Agilan Kaliappan Mark Vertue Anne Nicholson Joanne Riches Gracie Maloney

The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain.

10.1001/jama.2023.21407 article EN JAMA 2023-10-25

To assess the feasibility, tolerance and effectiveness of enteral nutrition in critically ill patients receiving invasive mechanical ventilation prone position for severe Acute Respiratory Distress Syndrome (ARDS).Prospective observational study conducted a multidisciplinary critical care unit tertiary hospital from January 2013 until July 2015. All with ARDS who received during period were included. Patients' demographics, severity illness (Acute Physiology Chronic Health Evaluation (APACHE...

10.1177/1751143719900100 article EN Journal of the Intensive Care Society 2020-01-14

<ns4:p><ns4:bold>Background: </ns4:bold>The epidemiology of critical illness in India is distinct from high-income countries. However, limited data exist on resource availability, staffing patterns, case-mix and outcomes illness. Critical care registries, by enabling a continual evaluation service provision, epidemiology, availability quality, can bridge these gaps information. In January 2019, we established the Indian Registry IntenSive to map capacity describe outcomes. this report,...

10.12688/wellcomeopenres.16152.2 preprint EN cc-by Wellcome Open Research 2020-10-21

Abstract Objectives To evaluate the applications of mobile phones in day to care epileptic patients as a diagnostic, prognostic and therapeutic tool. Methods Detailed search various field epileptology was made MEDLINE, Cochrane Central Register Controlled Trials, EMBASE, CINAHL, LILACS corresponding developer websites were also looked into regarding their technical specifications user friendliness. Results A plethora apps are available across platforms especially Android, iOS Windows....

10.1016/j.ijep.2015.02.002 article EN cc-by-nc-nd International Journal of Epilepsy 2015-03-10

Height measurement in the critical care unit is necessary for estimating ideal body weight and providing titrated patient care. In this study, we compare three methods of height assessment evaluate their level correlation inter-observer reproducibility. Heights 100 consecutive patients were assessed independently by two nurses supine, four point, arm span methods. Paired sample t-test, one-way analysis variance, Tukey's honestly significant difference post-hoc Bland-Altman plots performed to...

10.4103/0972-5229.169342 article EN Indian Journal of Critical Care Medicine 2015-01-01

We aimed to study the prevalence of frailty, evaluate risk factors, and understand impact on outcomes in India. This was a prospective registry-embedded cohort across 7 intensive care units (ICUs) included adult patients anticipated stay for at least 48 h. Primary exposure as defined by score ≥ 5 Clinical Frailty Scale primary outcome ICU mortality. Secondary in-hospital mortality resource utilization. used generalized linear models factors model association between frailty outcomes. 838...

10.1016/j.jcrc.2023.154509 article EN cc-by Journal of Critical Care 2023-12-21

<ns4:p><ns4:bold>Background:</ns4:bold> Coronavirus disease 2019 (COVID-19) has been responsible for over 3.4 million deaths globally and 25 cases in India. As part of the response, India imposed a nation-wide lockdown prioritized COVID-19 care hospitals intensive units (ICUs). Leveraging data from Indian Registry IntenSive care, we sought to understand impact pandemic on critical service utilization, case-mix, clinical outcomes non-COVID ICUs. </ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold>...

10.12688/wellcomeopenres.16953.1 preprint EN cc-by Wellcome Open Research 2021-06-18

<ns4:p><ns4:bold>Background:</ns4:bold> Coronavirus disease 2019 (COVID-19) has been responsible for over 3.4 million deaths globally and 25 cases in India. As part of the response, India imposed a nation-wide lockdown prioritized COVID-19 care hospitals intensive units (ICUs). Leveraging data from Indian Registry IntenSive care, we sought to understand impact pandemic on critical service utilization, case-mix, clinical outcomes non-COVID ICUs. </ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold>...

10.12688/wellcomeopenres.16953.2 preprint EN cc-by Wellcome Open Research 2021-11-10

In critically ill patients, acute kidney injury (AKI) and sepsis often coexist. This confounds the assessment of outcomes both AKI in these patients. Hence, this study, we compare with sepsis, without against a control cohort comprising patients neither nor sepsis.Prospective observational study conducted our critical care unit (CCU) between January July 2009. Data including demographic details, physiology chronic health evaluation (APACHE) III score, presence AKI, intensive (ICU) length...

10.5005/jp-journals-10071-23386 article EN Indian Journal of Critical Care Medicine 2019-08-01

<ns4:p><ns4:bold>Background: </ns4:bold>The epidemiology of critical illness in India is distinct from high-income countries. However, limited data exist on resource availability, staffing patterns, case-mix and outcomes illness. Critical care registries, by enabling a continual evaluation service provision, epidemiology, availability quality, can bridge these gaps information. In January 2019, we established the Indian Registry IntenSive to map capacity describe outcomes. this report,...

10.12688/wellcomeopenres.16152.1 preprint EN cc-by Wellcome Open Research 2020-07-30

Abstract Perampanel is a non-competitive antagonist at the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid) subtype of ionotropic glutamate receptor. It approved as an adjunctive therapy in focal epilepsy with or without secondarily generalised seizures patients aged &gt;12 years. This in-depth review describes structure, mechanism action, pharmacokinetic profile, indications, dosage and efficacy, contraindications, possible drug interactions, adverse effect profile its...

10.1016/j.ijep.2016.08.001 article EN cc-by-nc-nd International Journal of Epilepsy 2016-09-09

OBJECTIVE: To assess the ONSD with B Scan(10 MHz probe) and MRI(fat suppressed T2 weighted sequence) in patients Idiopathic Intracranial Hypertension(IIH) to compare significance of diagnosing raised intracranial pressure. BACKGROUND: The optic nerve sheath is direct communication subarachnoid space which forms physiological basis for using Optic Nerve Sheath Diameter(ONSD) as a surrogate pressure measurement. METHODS: 15 IIH were selected according Modified Dandy Criteria subjected...

10.1212/wnl.86.16_supplement.p6.316 article EN Neurology 2016-04-05

such as maximal inspiratory pressure (MIP), negative force (NIF), rapid shallow breathing index (RSBI), and imaging modalities diaphragmatic fluoroscopy ultrasound.However, to date, the transdiaphragmatic twitch in response phrenic nerve stimulation continues remain gold standard for assessment of DW. [10][11][12] Nevertheless, ultrasound is evolving preferred bedside tool, considering that it noninvasive, inexpensive, easily available, repeatable, allows serial assessments. 13Ultrasound-based

10.5005/jp-journals-11010-1111 article EN cc-by-nc-sa Indian Journal of Respiratory Care 2024-06-18

OBJECTIVES To evaluate the impact of an online educational intervention on improving knowledge antimicrobial resistance (AMR) and stewardship among final-year medical students in Chennai, India. METHODS This was a prospective ‘before-after’ study conducted across 5 colleges Participants who were (fourth year) undergraduate administered pretest to baseline knowledge. Students then provided access material comprising 20 short lectures. Lectures delivered by content experts covered range topics...

10.1177/23821205241239842 article EN cc-by-nc Journal of Medical Education and Curricular Development 2024-01-01

Objective: To assess the correlation between admission Aphasia Rapid Test (ART) score with Handicap scale (AHS) at discharge and to study variation in ART during period of stay. Background: rapid test is a quick, reliable reproducible language developed by C.Azuar A.Leger. Their showed high inter-rater reliability lack test-retest effect. Design/Methods: 46 patients who presented features acute stroke deficits were included. All underwent assessment addition detailed neurological examination...

10.1212/wnl.90.15_supplement.p3.230 article EN Neurology 2018-04-10

Disseminated Cysticercosis is a systemic parasitic infection by the larval stage of pork tape worm Taenia solium. It presents predominantly with neurological and extra symptoms. Neurocysticercosis involvement central nervous system encysted stage, ‘cysticercus cellulosae’ tapeworm widely prevalent in tropic. one commonest causes adult onset seizure tropics. In this report we discuss two cases disseminated cysticercosis current concepts imaging management cysticercosis.

10.1016/j.ijep.2017.10.002 article EN cc-by-nc-nd International Journal of Epilepsy 2017-10-28

Aim and objective: Obstructive sleep apnea (OSA) is a common yet underdiagnosed disorder associated with partial or complete obstruction of upper airway during sleep.Floppy eyelid syndrome (FES) another frequently overlooked diagnosis lax eyelids, soft foldable tarsus, chronic papillary conjunctivitis the palpebral conjunctiva.There has been growing literature to support association between two, this study explores same also clinical implications.Materials methods: Retrospective from 2015...

10.5005/jp-journals-10069-0062 article EN Indian Journal of Sleep Medicine 2020-01-01

Sunday, April 26April 14, 2020Free AccessProfile Of Patients With Guillain-Barre Syndrome During Pregnancy In A Tertiary Care Hospital South India. (4370)Namrata Jayaharan, Balasubramanian Samivel, Lakshmi Ranganathan, Shanmugasundaram N, and E Uma MaheshwariAuthors Info & AffiliationsApril 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.4370 Letters to the Editor

10.1212/wnl.94.15_supplement.4370 article EN Neurology 2020-04-14

OBJECTIVE: To identify the clinical differences in Cerebral Venous Sinus Thrombosis(CVST) depending upon anatomical site of obstruction. BACKGROUND: CVST has a varying cluster presentation each group namely superficial versus deep sinuses, isolated combined sinuses and paired unpaired sinuses. DESIGN/METHODS: Clinical manifestations were retrospectively studied among 90 consecutive patients confirmed by magnetic resonance venogram prognostic indicators correlated with outcome (assessed...

10.1212/wnl.84.14_supplement.p6.226 article EN Neurology 2015-04-06
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