A5103022323- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Antibiotics Pharmacokinetics and Efficacy
- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Long-Term Effects of COVID-19
- Urinary Tract Infections Management
- Antifungal resistance and susceptibility
- Nosocomial Infections in ICU
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Transplantation: Methods and Outcomes
- Pediatric Urology and Nephrology Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Emergency and Acute Care Studies
- Innovations in Medical Education
- Antibiotic Resistance in Bacteria
- Palliative Care and End-of-Life Issues
- Respiratory Support and Mechanisms
- Agricultural and Food Production Studies
- Family and Patient Care in Intensive Care Units
- Cardiac pacing and defibrillation studies
- SARS-CoV-2 and COVID-19 Research
- Central Venous Catheters and Hemodialysis
- Kidney Stones and Urolithiasis Treatments
Hospital Universitari i Politècnic La Fe
2012-2025
Instituto de Investigación Sanitaria La Fe
2012-2019
Leitat Technological Center
2015
Summary We conducted a multicentre study of 1844 patients from 42 Spanish intensive care units, and analysed the clinical characteristics brain death, use ancillary testing, decisions taken after diagnosis death. The main cause death was intracerebral haemorrhage (769/1844, 42%), followed by traumatic injury (343/1844, 19%) subarachnoid (257/1844, 14%). made rapidly (50% in first 24 h). Of those who went on to die, Glasgow Coma Scale admission ≤ 8/15 1146/1261 (91%) with haemorrhage, or...
Since the declaration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic,1 a small percentage children with disease 2019 (COVID-19) infection have required intensive care unit (ICU) admission an even smaller needing extracorporeal membrane oxygenation (ECMO) support.2,3 To provide contemporaneous data on ECMO utilization and activity during COVID-19 pandemic, European Chapter Extracorporeal Life Support Organization (EuroELSO) established prospective survey among...
Objective: Inflammatory markers have been assessed for the diagnosis and follow-up of ventilator-associated pneumonia (VAP), but their potential role in predicting risk VAP is unknown. We prospectively evolution cytokines mechanically ventilated patients predictive diagnostic VAP. Design: Prospective observational study. Setting: Medical intensive care unit. Patients: Mechanically patients. Exclusion criteria were active infection at admission subsequent extrapulmonary infection....
In this study, we evaluate the effect of extracorporeal membrane oxygenation (ECMO) and ventricular assist devices (Levitronix) on pharmacokinetic amikacin in critically ill patients. Twelve patients with ECMO three Levitronix who started treatment were included. Amikacin pre (Cmax) post (Cmin) dose serum concentrations measured during first 72–96 hours initiation. Pharmacokinetic parameters performed by Bayesian adjustment. The median initial was 1,000 mg (range: 600–1,400 mg). Mean plasma...
Abstract Background Isavuconazole is a new drug used to treat fungal infections. This study aims describe isavuconazole pharmacokinetics in critically ill patients, assess the potential influence of patient covariates, and evaluate relationship with clinical efficacy safety. Methods We conducted prospective, observational patients treated intravenous for at least 48 hours. Samples were collected between 48–96 hours onset treatment, predose (Cmin), 1 hour (Cmax) 12 (C50) after last dose....
Isavuconazole is used to treat fungal infections. This study aims describe isavuconazole pharmacokinetics in critically ill patients and evaluate their relationship with clinical efficacy patient safety. We conducted a prospective, observational treated intravenous isavuconazole. Samples were collected at predose (Cmin), 1 h (Cmax) 12 (C50) after the last dose. The plasma concentration was determined by high-performance liquid chromatography. between microbiological outcomes safety...
Health care associated infections (HCAI) are frequent in patients admitted to ICU and have a great impact on the clinical outcome.
Although mainly indicated for treatment of bleeding in haemophilia patients with inhibitors, recombinant activated factor VII (rFVIIa) has also been successfully used other situations. However, no data are available on its use the disseminated intravascular coagulation (DIC) secondary to septic shock. We report a man DIC and shock due retrocaecal appendicitis severe intra-abdominal after surgery. Despite conventional treatment, persisted, rFVIIa controlled haemorrhage. No side-effects...