A5087913844- Pluripotent Stem Cells Research
- Erythrocyte Function and Pathophysiology
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Protein Structure and Dynamics
- Reproductive Biology and Fertility
- Cervical Cancer and HPV Research
- Adenosine and Purinergic Signaling
- Blood properties and coagulation
- Receptor Mechanisms and Signaling
- Lipid Membrane Structure and Behavior
- CRISPR and Genetic Engineering
- 3D Printing in Biomedical Research
- Neonatal Health and Biochemistry
- Spectroscopy and Quantum Chemical Studies
- Metabolism and Genetic Disorders
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Ion channel regulation and function
- Uterine Myomas and Treatments
- Free Radicals and Antioxidants
- Renal and related cancers
- Photoreceptor and optogenetics research
- Pregnancy and preeclampsia studies
- Drug Transport and Resistance Mechanisms
The University of Sydney
2010-2023
University of Montana
2022-2023
Instituto de Estructura de la Materia
2020-2023
University College London
1954-2021
Robert Bosch (Australia)
2009-2020
University of California, San Francisco
2015-2017
Monash University
2011-2016
The University of Adelaide
2000-2016
Royal North Shore Hospital
2008-2014
Australian Research Council
2007
We wished to determine recurrences of bacterial vaginosis (BV) after treatment over the course 12 months and establish factors associated with recurrence.Women symptomatic BV (a Nugent score [NS] 7-10 or 4-6 >or=3 Amsel criteria) were enrolled. was treated 400 mg oral metronidazole twice a day for 7 days. Participants completed questionnaire vaginal swabs collected at 1, 3, 6, months; study end point an NS 7-10.A total 121 (87%) women 18 (13%) criteria enrolled; 130 (94%) returned >or=1...
Since 1984, we have treated 26 patients with malignant ovarian germ cell tumors a combination of bleomycin, etoposide (VP-16), and cisplatin (BEP) at The University Texas MD Anderson Cancer Center (UTMDACC). median age the was 19 years (range, 8 to 32). All underwent initial surgery (unilateral salpingo-oophorectomy in 14, unilateral plus abdominal hysterectomy one, bilateral or without 11 patients). Twenty had no residual disease, three less than equal 2 cm (one each, dysgerminoma, mixed,...
In Brief Objective: Bacterial vaginosis has been associated with hormonal factors and sexual practices; however, the cause is unclear, notion that bacterial a sexually transmitted infection still debated. To investigate whether specific practices or instead features in common infection, we compared behavioral associations women to vaginal candidiasis. Methods: Women symptoms of abnormal discharge odor who attended Melbourne Sexual Health Centre between July 2003 August 2004 were eligible for...
The development of cell therapeutics from embryonic stem (ES) cells will require technologies that direct differentiation to specific somatic lineages in response defined factors. initial step formation the ES cells, an intermediate, pluripotent primitive ectoderm-like cell, can be achieved vitro by early (EPL) a biological activity contained within conditioned medium MEDII. Fractionation MEDII has identified two activities required for EPL formation, with molecular mass <3 kDa and...
There is an increasing appreciation that amino acids can act as signaling molecules in the regulation of cellular processes through modulation intracellular cell pathways. In culture, embryonic stem (ES) cells be differentiated to a second, pluripotent population, early primitive ectoderm-like response biological activities within conditioned medium MEDII. The acid l-proline has been identified component MEDII required for ES differentiation. Here, we define primary transporter on and...
The δ and b subunits are both involved in binding the F1 to F0 part theEscherichia coli ATP synthase (ECF1F0). interaction of purified subunit isolated hydrophilic domain (bsol) has been studied here. Purified binds bsol weakly solution, as indicated by NMR studies protease protection experiments. On F1,i.e. presence ECF1-δ, δ, interact strongly, a complex ECF1·bsol can be native gel electrophoresis. Both protected from trypsin cleavage this complex. In contrast, is rapidly degraded when...
Groups of amino acids, and some selected added to media used for culture pre-implantation embryos have previously been shown improve development in various ways including survival the blastocyst stage, increased cell number improved hatching. In this study, we cultured 1-cell mouse 5 days hatching stage isosmotic medium (270 mOsm/kg) at high density (10 embryos/10 μL), where autocrine/paracrine support occurs, low (1 embryo/100 is minimized compromised. When 400 μM L-Pro or 1 mM L-Gln was...
PURPOSE To evaluate the efficacy and toxicity of intravenous vinorelbine as single-agent chemotherapy in patients with advanced or recurrent squamous cell carcinoma cervix. PATIENTS AND METHODS Between August 1993 July 1995, 35 cervix were entered onto this study. Patients had received no prior therapeutic chemotherapy. The initial dose 30 mg/m2 was administered a weekly infusion. Subsequent doses unchanged, reduced, escalated, omitted according to observed toxicity. evaluated for response...
To investigate and define better the role of salvage surgery for patients with chemorefractory gestational trophoblastic disease (GTD).A retrospective review medical records at The University Texas M.D. Anderson Cancer Center identified 33 GTD who underwent between 1962 1991. end points selected analysis were serologic response survival.Initial procedures consisted 29 hysterectomies, four thoracotomies, one nephrectomy (in conjunction a hysterectomy). Fourteen (42%) had complete (CR) to...
High-level quantum chemical procedures have been used to study how the C-H bond dissociation enthalpies (BDEs) of alcohols and related systems are affected by changes their protonation state. The high-level determined from a benchmark 25 neutral, protonated, deprotonated substituted methanes. calculations suggest that experimental BDEs for CH3NH2 CH3SH should be reassessed. We confirm previous findings increases alcohols, while deprotonation decreases BDEs. For prototypical alcohol,...
Replacement of pancreatic β-cells is one the most promising treatment options for type 1 diabetes (T1D), even though, toxic immunosuppressive drugs are required. In this study, we aim to deliver allogeneic β-cell therapies without antirejection using a bioengineered hybrid device that contains microencapsulated inside 3D polycaprolactone (PCL) scaffolds printed melt electrospin writing (MEW). Mouse (MIN6) pseudoislets and QS mouse islets encapsulated in alginate microcapsules, affecting...
Congenital hydrocephalus (CH) is a life-threatening medical condition in which excessive accumulation of CSF leads to ventricular expansion and increased intracranial pressure. Stenosis (blockage) the Sylvian aqueduct (Aq; narrow passageway that connects third fourth ventricles) common form CH humans, although genetic basis this unknown. Mouse models indicate Aq stenosis associated with abnormal development subcommmissural organ (SCO) small secretory located at dorsal midline caudal...
Tropoelastin is the soluble precursor of elastin that bestows tissue elasticity in vertebrates. at 20 °C phosphate-buffered saline, pH 7.4, but 37 equilibrium established between protein and insoluble coacervate. Sedimentation studies performed before (20 °C) after (37 coacervation showed component was strictly monomeric. velocity experiments revealed both temperatures tropoelastin exists as two independently sedimenting monomeric species present approximately equal concentrations. Species 1...