A5045187198- Health Systems, Economic Evaluations, Quality of Life
- Drug-Induced Adverse Reactions
- Pregnancy and Medication Impact
- HIV/AIDS drug development and treatment
- Pharmaceutical Economics and Policy
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Impact on Reproduction
- Pharmacology and Obesity Treatment
- HIV Research and Treatment
- Pregnancy and preeclampsia studies
- Blood disorders and treatments
- Mast cells and histamine
- Asthma and respiratory diseases
- Endometriosis Research and Treatment
- Diabetes Treatment and Management
- Cystic Fibrosis Research Advances
- Antifungal resistance and susceptibility
- Pneumonia and Respiratory Infections
- Healthcare cost, quality, practices
- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical studies and practices
- Quality and Safety in Healthcare
- Phenothiazines and Benzothiazines Synthesis and Activities
- Kidney Stones and Urolithiasis Treatments
- Pharmaceutical industry and healthcare
Pregistry (United States)
2023-2024
Thermo Fisher Scientific (United States)
2024
Bridge Pharma (United States)
2024
University Hospital Münster
2023
AbbVie (United States)
2018-2022
Abbott Fund
2000-2011
Altoona Center for Clinical Research
2006
Abbott (United Kingdom)
2006
Abbott (United States)
2005
St. Luke's-Roosevelt Hospital Center
2003
The long-term effects of sibutramine treatment on the rates cardiovascular events and death among subjects at high risk have not been established.
Background: Increased prevalence of adolescent obesity requires effective treatment options beyond behavior therapy. Objective: To see whether sibutramine reduced weight more than placebo in obese adolescents who were receiving a therapy program. Design: 12-month, 3:1 randomized, double-blind trial conducted from July 2000 to February 2002. Setting: 33 U.S. outpatient clinics. Participants: 498 participants 12 16 years age with body mass index (BMI) that was at least 2 units the weighted...
The Sibutramine Cardiovascular OUTcomes trial showed that sibutramine produced greater mean weight loss than placebo but increased cardiovascular morbidity not mortality. relationship between 12-month and subsequent outcomes is explored.Overweight/obese subjects (N = 10 744), ≥55 years with disease and/or type 2 diabetes mellitus, received plus management during a 6-week Lead-in Period before randomization to continue 4906) or receive 4898). primary endpoint was the time from first...
Background. Lopinavir/ritonavir has demonstrated antiviral activity in the HIV-infected adult. Subjects. The objective of this study was to investigate a liquid coformulation lopinavir/ritonavir, combination with reverse transcriptase inhibitors, children. Methods. One hundred antiretroviral (ARV)-naive and ARV-experienced, nonnucleoside inhibitor-naive children between 6 months 12 years age participated Phase I/II, open label, multicenter trial. Subjects initially received either 230/57.5...
Background Anaphylaxis, mediated by immunoglobulin E, may be clinically indistinguishable but is mechanistically different than chemically anaphylactoid reactions induced drugs such as morphine, curare, and vancomycin. A test to distinguish anaphylactic from would clarify therapeutic medicolegal issues. Tryptase levels identify have not been evaluated in vivo during reactions. prospective, randomized, double-blinded, placebo-controlled trial of antihistamine chemoprophylaxis for rapid...
Depending on the degree of underlying resistance present, optimization pharmacokinetics protease inhibitors may result in improved virologic suppression. Thirty-seven human immunodeficiency virus (HIV)-infected subjects who had chronic detectable viremia and were receiving 800 mg indinavir three times a day (TID) switched to 400 BID with ritonavir two (BID) for 48 weeks. Full pharmacokinetic evaluations obtained 12 before switch 3 weeks after switch. Combination therapy increased predose...
To determine whether pretreatment with intravenous antihistamines attenuates the symptoms of red-man syndrome associated rapid vancomycin administration.Prospective, randomized, double-blinded, placebo-controlled study patients undergoing elective arthroplasty.Preoperative unit in a tertiary care center.Forty preoperative (American Society Anesthesiologists status I-III, receiving prophylaxis for prosthetic joint replacement or revision.Elective orthopedic were randomly allocated to receive...
Available data regarding the safety and efficacy of sotrovimab in pregnant patients remain limited due to their exclusion from clinical trials. The COVID-19 International Drug Pregnancy Registry (COVID-PR) was established gather comprehensive women who have received monoclonal antibody (mAb) or antiviral treatments for mild, moderate, severe coronavirus disease 2019 (COVID-19) during pregnancy. Participants actively contributed self-reported concerning symptoms, addition sociodemographic...
The 2-position substituent on substrates or substrate analogues for glutamate dehydrogenase is shown to be intimately involved in the induction of conformational changes between subunits hexamer by coenzyme. These are associated with negative co-operativity exhibited this enzyme. 2-Oxoglutarate and L-2-hydroxyglutarate induce indications similar those induced oxidative deamination, glutamate, kinetic studies. Glutarate (2-position CH2) does not. A comparison effects D-2-hydroxyglutarate...
Rapid infusion of vancomycin causes histamine-mediated side effects, hypotension, and rash, known as "red man syndrome." In this prospective, randomized, double-blind, placebo-controlled study, we examined the ability oral antihistamines to attenuate three clinical end points: discontinuation, compared these findings with those a similar study using IV antihistamines. Patients (ASA physical status I-III) who required prophylaxis for elective arthroplasty received either (diphenhydramine...
Rapid infusion of vancomycin causes histamine-mediated side effects, hypotension, and rash, known as "red man syndrome." In this prospective, randomized, double-blind, placebo-controlled study, we examined the ability oral antihistamines to attenuate three clinical end points: discontinuation, compared these findings with those a similar study using IV antihistamines. Patients (ASA physical status I-III) who required prophylaxis for elective arthroplasty received either (diphenhydramine...
Nephrocalcin (NC), a urinary calcium oxalate monohydrate (COM) crystal growth inhibitor, was purified from kidneys of nine vertebrate species including humans. All isolates were glycoproteins with high contents aspartic and glutamic acids small amounts basic aromatic amino acids. Carbohydrate ranged 4 to 16 wt% among the different species, but all contained fucose, mannose, galactose, glucose, galactosamine, glucosamine, N-acetylneuraminic acid. Although acid carbohydrate compositions...
Background. Lopinavir/ritonavir has demonstrated antiviral activity in the HIV-infected adult. Subjects. The objective of this study was to investigate a liquid coformulation lopinavir/ritonavir, combination with reverse transcriptase inhibitors, children. Methods. One hundred antiretroviral (ARV)-naive and ARV-experienced, nonnucleoside inhibitor-naive children between 6 months 12 years age participated Phase I/II, open label, multicenter trial. Subjects initially received either 230/57.5...
Due to the exclusion of pregnant and lactating people from most clinical trials, there is an incomplete understanding risks benefits medication use in these populations therapeutic decision-making often conducted without adequate evidence. To change this paradigm, it imperative understand perspectives individuals concerning their participation trials.
Remdesivir (RDV), an inhibitor of coronavirus replication including SARS-CoV-2, has gained approval as a therapy for COVID-19. Nevertheless, its utilization during pregnancy lacks specific efficacy and safety data due to the exclusion pregnant patients from clinical trials. Authorization compassionate use in women was granted conduct phase 3 trials hospitalized adult with severe or moderate COVID manifestations. Overall, RDV seems be well-tolerated patients, rare occurrences adverse events....
Klippel-Trenaunay-Weber syndrome (KTWS) is a rare congenital systemic disease characterized by classic typical triad: cutaneous haemangioma, arterio-venous fistulas or varicosities (or both) and unilateral hypertrophy of hard soft tissue with different localizations. First described the French physicians Marcel Klippel Paul Trenaunay, in 1900, KTWS has clinically incidence 2–5/100000. The complete triad (port-wine stains, varicose veins, and/or bony hypertrophy) occurs almost 2/3 patients....