A5058144024- Cleft Lip and Palate Research
- COVID-19 Impact on Reproduction
- Craniofacial Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Folate and B Vitamins Research
- Pregnancy and Medication Impact
- Maternal Mental Health During Pregnancy and Postpartum
- Iron Metabolism and Disorders
- Congenital Anomalies and Fetal Surgery
- Genetic Associations and Epidemiology
- Pharmacological Effects and Toxicity Studies
- Pregnancy and preeclampsia studies
- Urological Disorders and Treatments
- Prenatal Screening and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Congenital Ear and Nasal Anomalies
- Genetic Mapping and Diversity in Plants and Animals
- dental development and anomalies
- Reproductive Health and Contraception
- Kruppel-like factors research
- Epilepsy research and treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Nutrition, Genetics, and Disease
Pregistry (United States)
2015-2024
Thermo Fisher Scientific (United States)
2024
Cracow University of Technology
2018
Boehringer Ingelheim (United Kingdom)
2013
Amgen (United States)
2008-2012
Boston University
2000-2010
Massachusetts General Hospital
2005-2008
University of Massachusetts Boston
2006
University of Southern California
2006
Boston Public Schools
2000-2005
Abstract With the development of multiple effective vaccines, reducing global morbidity and mortality COVID-19 will depend on distribution acceptance vaccination. Estimates vaccine among pregnant women mothers young children are yet unknown. An understanding challenges correlates to aid acceleration administration within these populations. Acceptance vaccination younger than 18-years-old, as well potential predictors, were assessed through an online survey, administered by Pregistry between...
<b>Objective:</b> To determine the rate of occurrence major malformations in infants whose mothers had taken drug valproic acid (VPA) as monotherapy during first trimester pregnancy and enrolled North American Antiepileptic Drug Pregnancy Registry. <b>Methods:</b> Data were collected from pregnant women throughout United States Canada through telephone-based interviews. Each woman was interviewed at enrollment, 7 months' gestation, postpartum. With her written permission, medical records...
Pregnant and postpartum women face unique challenges during the COVID-19 pandemic that may put them at elevated risk of mental health problems. However, few large-scale no cross-national studies have been conducted to date investigate modifiable pandemic-related behavioral or cognitive factors influence in this vulnerable group. This international study sought identify measure associations between information seeking, worries, prevention behaviors on perinatal pandemic. An anonymous, online,...
Pregnancy registries for women taking anticonvulsant drugs have been developed to determine more efficiently the fetal risks of each drug. A total 722 drug-exposed pregnancies are needed identify a sevenfold increase in rate occurrence specific abnormality, such as spina bifida, with frequency 1 1,000.The infants major malformations born 791 who had taken lamotrigine monotherapy and enrolled North American AED Registry were identified. Medical records obtained from affected infants' doctors....
Pulmonary complications of sickle cell anemia (Hb-SS) commonly cause morbidity, yet few large studies pulmonary function tests (PFTs) in this population have been reported.PFTs (spirometry, lung volumes, and diffusion capacity for carbon monoxide [DLCO]) from 310 adults with Hb-SS were analyzed to determine the pattern dysfunction their association other systemic disease.Raw PFT data compared predicted values. Each subject was subclassified into one five groups: obstructive physiology,...
Cutaneous leg ulcers are common in sickle cell anaemia and their risk might be genetically determined. Sickle patients were studied to examine the relationship of with haemolysis single nucleotide polymorphisms (SNPs) candidate genes that could affect vasoocclusion. Leg ulcer had lower haemoglobin levels higher lactate dehydrogenase, bilirubin, aspartate transaminase reticulocytes than did control but without ulcers. Age-adjusted comparisons showed anaemia-alpha thalassaemia was more...
Studies of preterm delivery after COVID-19 are often subject to selection bias and do not distinguish between early vs. late infection in pregnancy, nor spontaneous medically indicated delivery. This study aimed estimate the risk birth (overall, spontaneous, indicated) during while considering different levels disease severity timing.Pregnant recently pregnant people who were tested for or clinically diagnosed with pregnancy enrolled an international internet-based cohort June 2020 July...
Extensive epidemiological and genetic studies of the cause oral clefts have demonstrated strong familial aggregation but failed to yield definitive evidence any single mechanism. We used transmission/disequilibrium test (TDT) investigate relationship between markers associated with five candidate genes by utilizing 160 parent-offspring trios. Conditional logistic regression models extended TDT include covariates as effect modifiers, thus permitting tests for gene-environment interactions....
Abstract There is limited information about the effects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection during first trimester pregnancy on risk major congenital malformations (MCMs). The International Registry Coronavirus Exposure in Pregnancy (IRCEP) was designed to estimate relative adverse perinatal outcomes among women with Disease 2019 (COVID‐19) at specific times gestation. Adult were eligible enroll if they had a SARS‐CoV‐2 test, regardless results, or...
Abstract Objective: The members of the International Consortium for Oral Clefts Genetics recognize need collaboration between researchers involved in etiologic studies nonsyndromic cleft lip and palate palate. To address this need, consortium established four working subcommittees: diagnostic phenotypic assessment, molecular genetic studies, epidemiologic data collection analysis, analysis. These subcommittees were charged with development guidelines analysis that would facilitate both a...
Summary The complications of sickle cell disease are probably determined by genes whose products modify the pathophysiology initiated haemoglobin mutation. Priapism, one vaso‐occlusive manifestation disease, affects more than 30% males with disease. We examined possible association single nucleotide polymorphisms (SNPs) in 44 candidate different functional classes for an occurrence priapism. One hundred and forty‐eight patients anaemia incident or a confirmed history priapism were studied,...