Melinda Sothern

ORCID: 0000-0002-6609-5124
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About
Contact & Profiles
Research Areas
  • Obesity, Physical Activity, Diet
  • Children's Physical and Motor Development
  • Health and Lifestyle Studies
  • Child Nutrition and Feeding Issues
  • Diet and metabolism studies
  • Eating Disorders and Behaviors
  • Muscle metabolism and nutrition
  • Cardiovascular and exercise physiology
  • Obesity and Health Practices
  • Adipose Tissue and Metabolism
  • Physical Activity and Health
  • Birth, Development, and Health
  • Body Composition Measurement Techniques
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Pharmacology and Obesity Treatment
  • Child Nutrition and Water Access
  • Sports Performance and Training
  • Diet, Metabolism, and Disease
  • Clinical Nutrition and Gastroenterology
  • Urban Transport and Accessibility
  • Nutrition and Health in Aging
  • Adipokines, Inflammation, and Metabolic Diseases
  • Liver Disease Diagnosis and Treatment
  • Diabetes and associated disorders
  • Nutritional Studies and Diet

Louisiana State University Health Sciences Center New Orleans
2012-2023

Louisiana Cancer Research Center
2014-2019

Louisiana State University
2001-2019

Pennington Biomedical Research Center
2005-2019

Arizona State University
2018

University of New Orleans
1994-2015

University of Mississippi
2007-2015

University of Pennsylvania
2010-2014

Louisiana State University System
2010-2011

Institute on Aging
2010

Background: Increased prevalence of adolescent obesity requires effective treatment options beyond behavior therapy. Objective: To see whether sibutramine reduced weight more than placebo in obese adolescents who were receiving a therapy program. Design: 12-month, 3:1 randomized, double-blind trial conducted from July 2000 to February 2002. Setting: 33 U.S. outpatient clinics. Participants: 498 participants 12 16 years age with body mass index (BMI) that was at least 2 units the weighted...

10.7326/0003-4819-145-2-200607180-00005 article EN Annals of Internal Medicine 2006-07-18

Childhood socioeconomic status is linked to adult cardiovascular disease and risk. One proposed pathway involves inflammation due exposure a stress-inducing neighborhood environment. Whether CRP, marker of systemic inflammation, associated with stressful conditions among children unknown.The sample included 385 5-18 years age from 255 households 101 census tracts. Multilevel logistic regression analyses compared adolescents CRP levels >3 mg/L those ≤ 3 across environments. Among living in...

10.1371/journal.pone.0045419 article EN cc-by PLoS ONE 2012-09-25

The National Physical Activity Plan Alliance partnered with physical activity experts to develop a report card that provides comprehensive assessment of among United States children and youth.The 2014 U.S. Report Card on for Children Youth includes 10 indicators: overall levels, sedentary behaviors, active transportation, organized sport participation, play, health-related fitness, family peers, school, community the built environment, government strategies investments. Data from nationally...

10.1123/jpah.2014-0184 article EN Journal of Physical Activity and Health 2014-01-01

This study tested the efficacy of two school-based programs for prevention body weight/fat gain in comparison to a control group, all participants and overweight children. The Louisiana (LA) Health utilized longitudinal, cluster randomized three-arm controlled design, with 28 months follow-up. Children (N = 2,060; mean age 10.5 years, SD 1.2) from rural communities grades 4-6 participated study. Seventeen school clusters (mean 123 children/cluster) were randomly assigned one three arms: (i)...

10.1038/oby.2012.60 article EN Obesity 2012-03-08

Insulin sensitivity is impaired and ectopic fat (accretion of lipids outside typical adipose tissue depots) increased in obese adults adolescents. It unknown how early life this occurs; thus, it important to evaluate young children identify potential factors leading the development metabolic syndrome. We examined an ethnically diverse cohort healthy, exclusively prepubertal ( N = 123; F 57, M 66; age 8.04 ± 0.77 years) examine differences insulin visceral deposition between nonobese youth....

10.1038/oby.2011.264 article EN Obesity 2011-08-25

Drugs that improve chronic hyperglycemia independently of insulin signaling or reduction adiposity dietary fat intake may be highly desirable. Ad36, a human adenovirus, promotes glucose uptake in vitro proximal signaling. We tested the ability Ad36 to glycemic control vivo and determined if natural infection humans is associated with better control. C57BL/6J mice fed chow diet made diabetic high-fat (HF) were mock infected adenovirus Ad2 as for infection. Postinfection (pi), systemic...

10.1152/ajpendo.00703.2010 article EN AJP Endocrinology and Metabolism 2011-01-26

Objectives/Goals: Increased follicle-stimulating hormone (FSH) is linked to declines in ovarian and metabolic function older women. Obesity both a manifestation driver of aging pathologies. In animal models, FSH insulin resistance (IR) were reduced after 6 mos. nutritional therapeutic (GLYLO). Our goal was translate preclinical evidence humans. Methods/Study Population: An integrated, precision medicine approach identified unique phenotype aging-related debility relative females. A...

10.1017/cts.2024.1097 article EN cc-by-nc-nd Journal of Clinical and Translational Science 2025-03-26

Abstract Objective: The Wise Mind pilot study compared the efficacy of an environmental approach for prevention inappropriate weight gain in children with active control condition that used modifying expectancies related to use alcohol, tobacco, and drugs. Research Methods Procedures: A total 670 second sixth grade students from four schools were enrolled study. spanned 2 academic years, 586 available evaluation at end Two randomly assigned each treatment arm. focused on modification eating...

10.1038/oby.2007.597 article EN Obesity 2007-04-01

This study examined energy expenditure and physiologic determinants for marathon performance in recreational runners. Twenty runners participated (10 males aged 41 +/- 11.3 years, 10 females 42.7 11.7 years). Each subject completed a V(.-)O2max 1-hour treadmill run at recent pace, body composition was indirectly determined via dual X-ray absorptiometry. The male exhibited higher (ml x kg(-1) min(-1)) values (52.6 5.5) than their female counterparts (41.9 6.6), although ventilatory threshold...

10.1519/r-22666.1 article EN The Journal of Strength and Conditioning Research 2007-01-01

Neighbourhood parks may serve as a coping resource in post‐disaster communities, yet little is known about the impact of large‐scale disasters on park use. The objective this study to explore Hurricane Katrina (August 2005) use by visitors from flooded areas New Orleans, Louisiana, compared non‐flooded areas. In 2006 and 2007, following Katrina, 201 adults who visited 27 Orleans were interviewed. Visitors neighbourhoods used their less often likely engage animal interaction than...

10.1111/j.1467-7717.2010.01217.x article EN Disasters 2010-11-12

Objective: To investigate the hypotheses that in elementary school students: (1) adiposity and academic achievement are negatively correlated (2) physical activity positively correlated. Methods: Participants were 1963 children fourth to sixth grades. Adiposity was assessed by calculating body mass index (BMI) percentile percent fat with statewide standardized tests 4 content areas. Socioeconomic status age control variables. A subset of participants (n = 261) wore an accelerometer for 3...

10.1097/dbp.0b013e31825b849e article EN Journal of Developmental & Behavioral Pediatrics 2012-01-01

To evaluate the concordance between leisure-time sedentary behavior in adolescents assessed by an activity-based questionnaire and accelerometry. A convenience sample of 128 girls 73 boys, 11-15 years age (12.6 ± 1.1 years) from six states across United States examined as part feasibility studies for Trial Activity Adolescent Girls (TAAG). Three days self-reported time spent watching TV/videos, using computers, playing video/computer games, talking on phone was a modified version...

10.1186/1477-5751-10-2 article EN cc-by Journal of Negative Results in BioMedicine 2011-02-11

The prevalence of childhood obesity is rapidly increasing. Successful prevention and treatment depends on increasing the physical activity patterns obese youth. However, motivating child to participate in difficult.We designed a four-phase intervention, consisting structured progressive exercise program moderate intensity, along with motivational methods increase improve body movement awareness.Seventy-three overweight children participated weight management program. They had significant...

10.1097/00007611-199906000-00006 article EN Southern Medical Journal 1999-06-01

Safe and effective exercise programs are needed to prevent treat chronic diseases in childhood. In particular, preadolescent obese children should participate activities that specific their special needs.We included a moderate intensity, progressive resistance training program multidisciplinary weight management for children. The diet, behavior modification, aerobic flexibility exercises.The subjects reported no accidents or injuries 100% compliance with the minimum required prescription....

10.1097/00007611-199906000-00007 article EN Southern Medical Journal 1999-06-01

Abstract Objective: The conventional ratio method (milliliters O 2 per mass) typically is used to express V o peak. goal of the current study was compare peak obese girls with normal‐weight by and allometric scaling methods. Research Methods Procedures: We compared methods in 46 47 girls. Indirect calorimetry measure during either treadmill running or walking. Regression analysis determine coefficients for mass stature each group ANOVA data between groups. Results: were taller had higher...

10.1038/oby.2001.36 article EN Obesity Research 2001-05-01

BACKGROUND. Adolescent obesity is a major public health problem. Treatment options in addition to behavioral therapy could include pharmacotherapy with sibutramine. OBJECTIVES. Concerns regarding increases blood pressure and heart rate after sibutramine treatment some adult patients precipitated the present analysis, which evaluated cardiovascular safety of plus program obese adolescents. PATIENTS AND METHODS. With this 12-month, randomized, double-blind, placebo-controlled trial 33 US...

10.1542/peds.2006-2137 article EN PEDIATRICS 2007-06-18
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