Leslie Lewis

ORCID: 0000-0002-3467-6821
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About
Contact & Profiles
Research Areas
  • Infant Development and Preterm Care
  • Neonatal Respiratory Health Research
  • Neonatal and Maternal Infections
  • Neonatal and fetal brain pathology
  • Sepsis Diagnosis and Treatment
  • Infant Health and Development
  • Metabolism and Genetic Disorders
  • Family and Patient Care in Intensive Care Units
  • Infant Nutrition and Health
  • Pneumonia and Respiratory Infections
  • Congenital Heart Disease Studies
  • Neuroscience of respiration and sleep
  • Global Maternal and Child Health
  • Antibiotics Pharmacokinetics and Efficacy
  • Pediatric health and respiratory diseases
  • Military Strategy and Technology
  • Streptococcal Infections and Treatments
  • Respiratory Support and Mechanisms
  • Urinary Tract Infections Management
  • Nosocomial Infections in ICU
  • Neonatal Health and Biochemistry
  • Pharmacological Effects and Toxicity Studies
  • Military and Defense Studies
  • Breastfeeding Practices and Influences
  • Defense, Military, and Policy Studies

Manipal Academy of Higher Education
2016-2025

Kasturba Medical College, Manipal
2016-2025

Lewis University
2025

Russell Group
2025

The University of Texas at Dallas
2023

Kasturba Medical College Hospital
2017-2022

Manipal Hospital
2017-2019

Leeds and York Partnership NHS Foundation Trust
2014

University of York
2014

Duquesne University
2013

Epidemiology and surveillance of neonatal sepsis helps in implementation rational empirical antibiotic strategy. To study the frequency bacterial isolates early onset (EONS) their sensitivity pattern. In this retrospective study, a case EONS was defined as an infant who had clinical signs or born to mothers with potential risk factors for infection, whom blood culture obtained within 72 hours life, grew pathogen. Blood sample included single from peripheral vein artery. Relevant data unit...

10.1186/1824-7288-37-32 article EN cc-by ˜The œItalian Journal of Pediatrics/Italian journal of pediatrics 2011-01-01

SummaryA transient period of hypercholesterolemia and hyperlipemia may accompany the early stage severe diabetes mel-litus in rabbits following injection alloxan. It occurred varying degrees many that survived with persistent always if was enough to cause death. A dosage 50 mg/kg alloxan failed or hypercholesterolemia, 100 produced it one 3 rabbits, while 125 effective 29 32 animals. Lesions were found adrenal cortices 12 25 animals dying after receiving

10.3181/00379727-60-15133 article EN Experimental Biology and Medicine 1945-11-01

To gain an understanding of the variation in available resources and clinical practices between neonatal units (NNUs) low-income middle-income country (LMIC) setting to inform design observational study on burden unit-level antimicrobial resistance (AMR).A web-based survey using a REDCap database was circulated NNUs participating Neonatal AMR research network. The included questions about NNU funding structure, size, admission rates, access supportive therapies, empirical guidelines period...

10.1136/archdischild-2019-316816 article EN cc-by-nc Archives of Disease in Childhood 2019-08-24

Physical stress, including high temperatures, may damage the central metabolic nicotinamide nucleotide cofactors [NAD(P)H], generating toxic derivatives [NAD(P)HX]. The highly conserved enzyme NAD(P)HX dehydratase (NAXD) is essential for intracellular repair of NAD(P)HX. Here we present a series infants and children who suffered episodes febrile illness-induced neurodegeneration or cardiac failure early death. Whole-exome whole-genome sequencing identified recessive NAXD variants in each...

10.1093/brain/awy310 article EN Brain 2018-11-21

We describe a novel method to monitor pulse rate (PR) on continuous basis of patients in neonatal intensive care unit (NICU) using videos taken from high definition (HD) webcam. algorithms that determine PR videoplethysmographic (VPG) signals extracted multiple regions interest (ROI) simultaneously available within the field view camera where cardiac signal is registered. detect motion video images and compensate for artifacts each ROI. Preliminary clinical results are presented 8 neonates...

10.1109/embc.2014.6944455 article EN 2014-08-01

Aim: The aim of the present study is to develop a liquid chromatography-mass spectrometry method measure two important biomarkers biotin deficiency from dried blood spot samples for effective management disorder. Materials & methods: was developed on system using pentafluorophenyl column employing mobile phase composition methanol and water in isocratic mode. A full validation performed as per relevant guidelines. Results conclusion: Correlation between results plasma evaluated determine...

10.1080/20565623.2024.2355038 article EN cc-by-nc Future Science OA 2024-07-04

Abstract Objective: The Wise Mind pilot study compared the efficacy of an environmental approach for prevention inappropriate weight gain in children with active control condition that used modifying expectancies related to use alcohol, tobacco, and drugs. Research Methods Procedures: A total 670 second sixth grade students from four schools were enrolled study. spanned 2 academic years, 586 available evaluation at end Two randomly assigned each treatment arm. focused on modification eating...

10.1038/oby.2007.597 article EN Obesity 2007-04-01

<ns4:p>Background Quality of neonatal transport services may impact outcomes. We assessed the effect skill-based education ambulance personnel (AP) on outcomes transported neonates. Methods conducted a single-arm intervention study (pre and post) over 18 months. perceptions practices AP along with equipment availability/usage. compared clinical vital parameters at arrival from Neonatal Intensive Care Unit (NICU) pre versus post intervention. analysed data using SPSS version 25. Results Of 77...

10.12688/f1000research.150058.2 preprint EN cc-by F1000Research 2025-01-02

Purpose: Investigate the effect of structured neonatal physical therapy program (SNP) on neurodevelopmental outcomes moderate and late preterm (MLP) infants. Methods: Sixty MLP infants were randomly allocated to usual care (UC) or SNP. A previous publication reported component SNP at hospital discharge. This paper examined SNP’s motor, cognitive language 3 6 months using a 2-way mixed design ANOVA. Results: Both groups similar baseline for motor scores. Infants receiving significantly...

10.1097/pep.0000000000001181 article EN Pediatric Physical Therapy 2025-01-07

ABSTRACT Background Preterm birth is a highly stressful experience for both parents and infants. Parental participation in care enhances developmental outcomes, fosters parent–infant interactions builds parental confidence. However, low adherence has always been challenge the successful implementation of intervention programs NICU at home. It imperative to understand parents' perspectives view challenges that they through their lens while providing early infants born preterm. This study...

10.1111/cch.70045 article EN cc-by-nc Child Care Health and Development 2025-02-06

The aim of this study was to understand first-time mothers' experience caring for their preterm infant in an Indian context using a descriptive qualitative design. Six mothers infants were interviewed semi-structured interview guide. Thematic analysis revealed the overarching theme "striving be mother with special needs," three categories: contextual constraints at hospital and home, personal limitations coping strategies. findings highlight importance recognizing addressing unique needs infants.

10.1080/07380577.2025.2472420 article EN Occupational Therapy In Health Care 2025-03-11

Neonatal sepsis is a severe systemic infection occurring within the first month of life and remains significant cause morbidity mortality worldwide, particularly in low- middle-income (LMICs). Despite advancements medical care, challenges such as limited healthcare access inadequate diagnostic capabilities persist. This study explores impact real-time data analytics on managing neonatal sepsis, highlighting its potential to enhance early detection, diagnosis, treatment outcomes intensive...

10.47836/pjst.33.3.13 article EN Pertanika journal of science & technology 2025-04-04

Abstract Background Maintaining amikacin concentrations within a specific therapeutic window is crucial to avoid sub-therapeutic or toxic levels. This study aimed design dosing nomogram for in neonates using Population Pharmacokinetic (PopPK) modeling approach. Methods PopPK model was developed 101 from 80 and validated diagnostics, empirical Bayesian forecasting performed. profiles were simulated virtual subjects with range of covariates identify suitable dosage regimens. Dosage regimens...

10.1038/s41390-025-04044-7 article EN cc-by Pediatric Research 2025-04-10
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