A5061803568- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Obesity and Health Practices
- Nutritional Studies and Diet
- Virus-based gene therapy research
- Diet and metabolism studies
- Food Security and Health in Diverse Populations
- Genetic Associations and Epidemiology
- Dietary Effects on Health
- Behavioral Health and Interventions
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Genetic and phenotypic traits in livestock
- Nutrition, Genetics, and Disease
- Viral Infectious Diseases and Gene Expression in Insects
- Bariatric Surgery and Outcomes
- Body Composition Measurement Techniques
- Psychological Well-being and Life Satisfaction
- Nutrition and Health in Aging
- Neurobiology and Insect Physiology Research
- Muscle metabolism and nutrition
- Birth, Development, and Health
- Pharmacology and Obesity Treatment
- Body Contouring and Surgery
- CAR-T cell therapy research
Lubbock Christian University
2019-2024
Bailey Tool & Manufacturing (United States)
2024
Texas Tech University
2015-2021
University of Alabama at Birmingham
2012-2016
Pennington Biomedical Research Center
2011-2013
Louisiana State University
2013
Louisiana State University System
2011-2012
Energetics (United States)
2012
Louisiana State University Agricultural Center
2011
It has been shown that caloric restriction (CR) delays aging and possibly the development of Alzheimer's disease (AD). We conjecture mechanism may involve interoceptive cues, rather than reduced energy intake per se. determined hunger alone, induced by a ghrelin agonist, reduces AD pathology improves cognition in APP-SwDI mouse model AD. Long-term treatment with agonist was sufficient to improve performance water maze. The also levels amyloid beta (Aβ) inflammation (microglial activation) at...
Drugs that improve chronic hyperglycemia independently of insulin signaling or reduction adiposity dietary fat intake may be highly desirable. Ad36, a human adenovirus, promotes glucose uptake in vitro proximal signaling. We tested the ability Ad36 to glycemic control vivo and determined if natural infection humans is associated with better control. C57BL/6J mice fed chow diet made diabetic high-fat (HF) were mock infected adenovirus Ad2 as for infection. Postinfection (pi), systemic...
Reducing dietary fat intake and excess adiposity, the cornerstones of behavioral treatment insulin resistance(IR), are marginally successful over long term. Ad36, a human adenovirus, offers template to improve IR, independent or adiposity. Ad36 increases cellular glucose uptake via Ras-mediated activation phosphatidyl inositol 3-kinase(PI3K), improves hyperglycemia in mice, despite high-fat diet without reducing Ex-vivo studies suggest that mice by increasing adipose tissue skeletal muscle,...
Although thiazolidinediones (TZD) effectively improve hyperglycemia and increase adiponectin, a proinsulin-sensitizing adipokine, they also adipogenesis via peroxisome proliferator-activated receptor (PPAR)γ induction, which may be undesirable. Recent safety concerns about some TZD have prompted the search for next generation agents that can enhance glycemic control adiponectin independent of PPARγ or adipogenesis. Reminiscent action, human adenovirus, adenovirus 36 (Ad36), up-regulates...
Hepatic steatosis often accompanies obesity and insulin resistance. The cornerstones of treatment include reducing body weight dietary fat intake, which are marginally successful over the long term. Ad36, a human adenovirus, may offer template to overcome these limitations. In vitro in vivo studies collectively indicate that via its E4orf1 protein, Ad36 improves hyperglycemia, attenuates hepatic steatosis, despite high diet without loss. Considering sensitivity, or synthesis, oxidation,...
Impaired glycemic control and excessive adiposity are major risk factors for Type 2 Diabetes mellitus. In rodent models, Ad36, a human adenovirus, improves control, independent of dietary fat intake or adiposity. It is impractical to use Ad36 therapeutic action. Instead, we identified that E4orf1 protein mediates its anti-hyperglycemic action insulin signaling. To further evaluate the potential improve established stable 3T3-L1 cell system in which expression can be regulated. The...
Objective Subjective social status (SSS), perceived rank in the ladder, is associated with weight, but determinants of SSS youth remain unknown. Relationships between and income, food insecurity, parent SSS, BMI change were investigated during an obesity intervention. Methods Data came from a family‐centered, community‐based intervention for low‐income families. Parent assessed using validated, age‐appropriate scale. Food insecurity socioeconomic factors parents; child weight‐related data...
<b><i>Background/Aims:</i></b> To quantify the extent to which increase in obesity observed across recent generations of American population is associated with individual or combined effects assortative mating (AM) for body mass index (BMI) and differential realized fertility by BMI. <b><i>Methods:</i></b> A Monte Carlo framework formed informed using data collected from National Longitudinal Survey Youth (NLSY). The model has 2 portions: one...
This randomized trial experimentally manipulated social status to assess effects on acute eating behavior and 24-hour energy balance.Participants (n = 133 Hispanics; age 15-21 years; 60.2% females) were low ("LOW") or high ("HIGH") conditions in a rigged game of Monopoly (Hasbro, Inc.). Acute intake lunchtime meal was measured by food scales. Twenty-four-hour balance assessed via summation resting metabolic rate (metabolic cart), physical activity expenditure (accelerometer), thermic effect...