A5100430409- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Transplantation: Methods and Outcomes
- Orthopedic Infections and Treatments
- RNA Research and Splicing
- NF-κB Signaling Pathways
- Molecular Biology Techniques and Applications
- interferon and immune responses
Harvard University
2023
Massachusetts General Hospital
2023
Sun Yat-sen Memorial Hospital
2022
Sun Yat-sen University
2022
University of South China
2022
Second People's Hospital of Yunnan Province
2021
Kunming Medical University
2021
Yunnan University
2021
Soochow University
2021
First Affiliated Hospital of Soochow University
2021
Ischemia-reperfusion injury is a common early complication after lung transplantation. It was reported that long non-coding RNA (lncRNA) metastasis-associated adenocarcinoma transcript 1 (MALAT1) involved in ischemia-reperfusion and regulates inflammation. This study aimed to explore the role of MALAT1 inflammatory following transplant (LTIR). A LTIR rat model successfully established, with expression interleukin-8 (IL-8) tissues detected. Then, vitro loss- gain-of-function investigations...
Hepatocellular carcinoma (HCC) is one of the most severe malignant cancers that leads to high death rate worldwide. Recent research revealed long non-coding RNAs (lncRNAs) exert a critical role regarding chemoresistance in numerous cancers, including HCC.Our aimed explore function and molecular mechanism lncRNA PCGEM1 on oxaliplatin resistance HCC vitro.Expression PCGEM1, together with miR-129-5p, mRNA level ETV1 drug resistance-related genes LRPA, MDR1 MDR3 were determined using...
Osteomyelitis is one of the most challenging diseases in field orthopedics for its complex pathogenesis and unsatisfactory treatment. The mechanism underlying occurrence development still unclear. In our previous study, we found that long non-coding RNA (lncRNA) NONHSAT009968 inhibited ability osteogenic differentiation staphylococcal protein A (SPA)-treated human bone marrow mesenchymal stem cells (hBMMSCs), but remains current study was aimed at elucidating possible regulating defect...
To investigate the effects of a synthetic small double-stranded RNA (dsRNA) dsP21-555 on development bladder cancer cell lines T24 and EJ.According to different treatments, cells were divided into three groups: negative control group (transfected with dsControl), positive candidate microRNA, i.e. miR-370) experimental dsP21-555). Real-time fluorescent quantitative polymerase chain reaction (qPCR) was conducted detect expressions p21 mRNA cyclin-dependent kinases 4/6 (CDK4/6) mRNA; Western...
Abstract Background: Laryngeal squamous cell carcinoma (LSCC) is prevalent in the Chinese population, where smoking a major carcinogen. MicroRNAs (miRNAs) and their gene targets potentially contribute to multistep regulatory processes of LSCC development. Objective: The purpose this study investigate validate aberrant expressed miRNAs LSCC, analyze putative target genes screened miRNAs. Methods: Six pairs primary Stage II-IV adjacent non-neoplastic tissues were surgically removed for miRNA...
<p>Supplementary Data.</p>
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