Photoredox catalysis is a rapidly evolving platform for synthetic methods development. The prominent use of acridinium salts as sustainable option photoredox catalysts has driven the development more robust and synthetically useful versions based on this scaffold. However, complicated syntheses, increased cost, limited commercial availability have hindered adoption these by greater community. By utilizing direct conversion xanthylium salt into corresponding key transformation, we present an...

We report a formal [4+2] cycloaddition reaction of styrenes under visible-light catalysis. Two styrene molecules with different electronic or steric properties were found to react each other in good yield and excellent chemo- regioselectivity. This provides direct access polysubstituted tetralin scaffolds from readily available styrenes. Sophisticated tricyclic tetracyclic analogues prepared high up 20/1 diasteroselectivity cyclic substrates.

Abstract Aldehydes are among the most versatile functional groups for synthetic chemistry. However, access to polysubstituted alkyl aldehydes is very limited and requires lengthy routes that involve multiple‐step functional‐group conversion. This paper reports a one‐step synthesis of from readily available olefin substrates using visible‐light photoredox catalysis. Despite number competing reaction pathways, commercial styrenes react with vinyl ethers selectively in presence an acridinium...

An efficient photocatalytic C–N cross-coupling of nitroarenes with haloarenes has been developed using simple and cheap Ni(acac)2 as a cocatalyst. The reaction is confirmed stepwise process: (1) metal free photoinduced reduction into aniline derivatives (2) photo- Ni-catalyzed anilines haloarenes. conditions are mild, giving high-value diarylamines good to excellent yields functional group tolerance.

A range of alkene-linked phenols are generally and reliably dearomatized specifically at their ortho-positions to create all-carbon quaternary stereogenic centers the corresponding spiro-ring junctions, thus establishing a viable solution long-standing synthetic challenge.

Abstract Amino acids play significant roles in the study of life sciences, pharmaceutical R&D, bioengineering, and so on. Artificial amino acid‐based drugs are important advancing therapeutic innovation for multiple diseases including chronic pain, diabetes, Alzheimer's disease. On other hand, multicomponent reactions (MCRs) demonstrated to be a powerful strategy construction complicated structures from readily accessible starting reagents one pot. Thus, applying preparation their...

Abstract We report a formal [4+2] cycloaddition reaction of styrenes under visible‐light catalysis. Two styrene molecules with different electronic or steric properties were found to react each other in good yield and excellent chemo‐ regioselectivity. This provides direct access polysubstituted tetralin scaffolds from readily available styrenes. Sophisticated tricyclic tetracyclic analogues prepared high up 20/1 diasteroselectivity cyclic substrates.

We have developed a novel electron-donor-acceptor (EDA) photocatalyst through DFT-guided design. This is formed in situ from isoquinoline, diboron reagent, and weak base, can be effectively utilized for challenging reactions.

A visible-light-mediated protocol for direct oxidative decarboxylative coupling of various cinnamic acid derivatives with tetrahydrofuran was developed, leading to simple preparations a range vinyltetrahydrofurans under operationally mild and convenient conditions.

We reported a facile metal-free conversion of aryl halides to the corresponding boronic esters catalysed by an in situ formed donor–acceptor complex. A two-step one-pot method was also developed for site selective aromatic C–H bond borylation.

Abstract Aldehydes are among the most versatile functional groups for synthetic chemistry. However, access to polysubstituted alkyl aldehydes is very limited and requires lengthy routes that involve multiple‐step functional‐group conversion. This paper reports a one‐step synthesis of from readily available olefin substrates using visible‐light photoredox catalysis. Despite number competing reaction pathways, commercial styrenes react with vinyl ethers selectively in presence an acridinium...

Polysubstituted bicyclic acetals are a class of privileged pharmacophores with unique 3D structure and an adjacent pair hydrogen bond acceptors. The key, fused acetal functionality is often assembled, via intramolecular cyclization, from linear substrates that not readily available. Herein, we report formal cycloaddition between cinnamyl alcohols cyclic enol ethers under ambient photoredox catalysis conditions. can be prepared in one step available building blocks. Employment sugar-derived...

Due to boron’s metalloid properties, aromatic boron reagents are prevalent synthetic intermediates. The direct borylation of aryl C-H bonds for producing compounds offers an appealing, one-step solution. Despite significant advances in this field, achieving regioselective bond using simple and readily available starting materials still remains a challenge. In work, we attempted enhance the reactivity electron-donor-acceptor (EDA) complex by selecting different bases replace organic base...

A range of phenols bearing multiple useful functionalities at their <i>meta</i> positions were prepared from the corresponding quinols under cooperative effects visible light irradiation, Ru(bpy)₃Cl₂ photosensitizer, Hünig’s base, LiBF₄, and MeCN solvent. The process involves visible-light-enabled photocatalytic cleavage C–O bond as strategic event.