A5068974483- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Connexins and lens biology
- Glaucoma and retinal disorders
- Advanced Glycation End Products research
- Retinal and Macular Surgery
- Retinal Development and Disorders
- Aldose Reductase and Taurine
- Traumatic Ocular and Foreign Body Injuries
- Ophthalmology and Visual Impairment Studies
- Ocular Diseases and Behçet’s Syndrome
- Biochemical effects in animals
- Facial Trauma and Fracture Management
- Innovations in Medical Education
- Ophthalmology and Visual Health Research
- Mitochondrial Function and Pathology
- Global Healthcare and Medical Tourism
- Kidney Stones and Urolithiasis Treatments
- Patient-Provider Communication in Healthcare
- Artificial Intelligence in Healthcare and Education
- Anatomy and Medical Technology
- Restraint-Related Deaths
- Data-Driven Disease Surveillance
- Traumatic Brain Injury and Neurovascular Disturbances
Case Western Reserve University
2015-2023
University School
2019-2023
University Hospitals of Cleveland
2023
Cleveland Eye Clinic
2019-2021
Cleveland Clinic
2019-2021
Institute of Bioinformatics
2019
The Neurological Institute
2019
Fairview School District
2014-2015
Artificial intelligence (AI), or the use of automated systems that display ability to correctly interpret, learn from, and achieve specific goals by external data, is an emerging technology has myriad implications for changing way we interact with world. Although this already being used in many fields such as banking, retail, education, AI potential transform other including healthcare. Within healthcare, ophthalmology uniquely positioned benefit from not only through clinical decision...
Low glutathione levels are associated with crystallin oxidation in age-related nuclear cataract. To understand the role of cysteine residue oxidation, we used novel approach comparing human cataracts glutathione-depleted LEGSKO mouse lenses for intra- versus intermolecular disulfide crosslinks using 2D-PAGE and proteomics, then systematically identified vivo vitro all forming sites ICAT labeling method coupled proteomics. Crystallins rich intramolecular disulfides were abundant at young age...
Age-related cataractogenesis is associated with disulfide-linked high molecular weight (HMW) crystallin aggregates. We recently found that the lens disulfidome was evolutionarily conserved in human and glutathione-depleted mouse (LEGSKO) cataracts it could be mimicked by oxidation vitro (Mol. Cell Proteomics, 14, 3211-23 (2015)). To obtain a comprehensive blueprint of oxidized key regulatory cytoskeletal proteins underlying cataractogenesis, we have now used same approach to determine,...
Purpose: Evaluating outcomes in patients receiving intravitreal antivascular endothelial growth factor (VEGF) inhibitors for neovascular age-related macular degeneration whom experience a lapse treatment. Methods: A retrospective chart review evaluating 3,304 ≥18 years who experienced treatment lapses ≥3 months compared with control counterparts. Demographic information, thickness as measured by central subfield thickness, and visual acuity were collected at baseline, the first postlapse...
The efficacy of mineralocorticoid receptor antagonist eplerenone to treat chronic central serous chorioretinopathy (CSCR) has been established. However, previous studies have limited by small cohort size and short follow-up duration. This study aims report 3-year clinical outcomes patients treated with for CSCR.Institutional review board-approved retrospective chart analysis at a single institution from 2012 2018. Baseline best-corrected visual acuity anatomical measurements related degree...
Diabetic macular edema (DME) is a leading cause of vision loss in diabetics. Anti-vascular endothelial growth factor (VEGF) therapy has been shown to be an effective treatment option for DME, although the injections are costly and require frequent visits, which increases risk unintended lapses. The aim this study characterize effects lapse patients with DME undergoing anti-VEGF therapy.Retrospective, comparative case series.This retrospective chart review compared seen multicenter...
Γ-Crystallins play a major role in age-related lens transparency. Their destabilization by mutations and physical chemical insults are associated with cataract formation. Therefore, drugs that increase their stability should have anticataract properties. To this end, we screened 2560 Federal Drug Agency–approved natural compounds for ability to suppress or worsen H2O2 and/or heat-mediated aggregation of bovine γ-crystallins. The top two drugs, closantel (C), an antihelminthic drug, gambogic...
Oxidative stress-induced mitochondrial dysfunction is implicated in the pathogenesis of age-related macular degeneration (AMD). Oxidized flavoprotein fluorescence (FPF) may serve as a quantifiable biomarker oxidative stress, reported either mean score for entire image (intensity) or variability (heterogeneity). This study examines FPF intensity and heterogeneity across large patient cohort various Beckman stages AMD.This enrolled patients with isolated AMD healthy control no retinopathy...
Purpose: To evaluate the depth and pattern of retinal hemorrhage in acute central vein occlusion (CRVO) to correlate these with visual anatomic outcomes. Methods: Retinal hemorrhages were evaluated color fundus photography fluorescein angiography at baseline follow-up. Snellen acuity (VA), foveal thickness (CFT), extent ischemia, development neovascularization analyzed. Results: 108 eyes from patients evaluated. Mean age was 63.6 ± 16.1 years a predilection for right eye (73.1%). Average...
Although people of low socioeconomic status (SES) and certain racial groups are at greater risk developing diabetic macular edema (DME), the extent these high-risk experience treatment differences is unknown. This study characterizes anti-vascular endothelial growth factor (anti-VEGF) injection use for DME.Data were collected from an electronic health record Cole Eye Institute, Cleveland Clinic Foundation patients who received anti-VEGF DME between 2012 2019 (N = 500).White on average more...
To determine which optical parameter profiles (OPPs) can be utilized to improve the visualization of epiretinal membranes (ERMs) and internal limiting membrane (ILM) using a three-dimensional heads-up microscope during 25-gauge pars plana vitrectomy.Fourteen independent graders were asked complete questionnaire comparing each OPPs against unaltered control image for given surgical case.Analysis graders' responses indicated that higher values hue are correlated with better ERM/ILM before...
Background: Few studies exist examining the frequency of primary headache in children with celiac disease and impact a gluten-free diet on symptomology. This study explores characteristics headaches response to at single institution. Methods: Medical records were reviewed for confirmed by presence elevated tissue transglutaminase IgA levels histologic changes consistent diagnosis small bowel biopsy. Eligible participants contacted via letter participation phone survey regarding headaches....
Background: Segmental neurofibromatosis was initially described by Miller and Sparks (1977) as manifestations of limited to a dermatomal, localized distribution. Now termed mosaic neurofibromatosis, previous literature this disease in children adolescents with individual case reports small-numbered series. This study presents large series neurofibromatosis. Methods: A retrospective chart review single institution medical record database performed on all cases diagnosed between the years 1998...
Optometrists play a preventive role in diabetic care by detecting early signs of retinopathy (DR), leading cause blindness adults. This study demonstrates that additional training can improve optometrists' ability to assess the presence and severity DR individuals with diabetes.This aimed determine impact quality improvement intervention involving education, assessment, feedback on improving evaluation referral patterns optometrists regard their patients diabetes.A pre-interventional...
The purpose of this study was to evaluate the difference between widefield confocal scanning laser imaging (WSLO) and broad line fundus (WBLF) in their ability view peripheral retina routine clinical practice.A retrospective chart review identified patients within practice who were imaged with a WSLO image single montaged WBLF image. primary outcome number ultra-widefield quadrants captured utilizing UWF consensus definitions. Secondary outcomes included area each quadrant differences...
As prostate cancer (PCa) screening decisions often occur in outpatient primary care, a brief tool to help the PCa conversation busy clinic settings is needed.A previously created 9-item aid discussions was tested five diverse care clinics. Fifteen providers were recruited use for 4 weeks, and revised based upon feedback. The then used with convenience sample of patients during routine visits. Pre- post-visit surveys administered assess patients' knowledge option be screened specific factors...
In clinical practice, visual acuity (VA) outcomes after treatment may be associated with multiple optical coherence tomography (OCT) variables including central subfield thickness (CST), ellipsoid zone (EZ) disruption , epiretinal membrane, vitreoretinal interface abnormalities, and disorganization of retinal inner layers (DRIL). Since CST has shown only a modest correlation VA, additional OCT-based prognostic factors can useful. DRIL is an OCT derived variable that factor. Ischemia...