A5048418763- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- RNA Research and Splicing
- Nuclear Structure and Function
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Peanut Plant Research Studies
- Surface Modification and Superhydrophobicity
- Planarian Biology and Electrostimulation
- Protist diversity and phylogeny
- Coconut Research and Applications
- Gastrointestinal disorders and treatments
- Animal Genetics and Reproduction
- Phytochemistry and Biological Activities
- Nitrogen and Sulfur Effects on Brassica
- Lipid metabolism and disorders
- Plant Toxicity and Pharmacological Properties
- Coenzyme Q10 studies and effects
- Sesquiterpenes and Asteraceae Studies
- MicroRNA in disease regulation
- Plant Disease Resistance and Genetics
- DNA Repair Mechanisms
- Apelin-related biomedical research
- Cellular Mechanics and Interactions
Hefei National Center for Physical Sciences at Nanoscale
2018-2024
University of Science and Technology of China
2018-2024
Center for Excellence in Molecular Cell Science
2019-2022
Morehouse School of Medicine
2018-2022
Institute of Crop Sciences
2022
Chinese Academy of Agricultural Sciences
2022
Yangzhou Vocational University
2022
Nanjing Forestry University
2021
Beihua University
2021
Lanzhou University
2020
Although the dynamic instability of microtubules (MTs) is fundamental to many cellular functions, quiescent MTs with unattached free distal ends are commonly present and play important roles in various events power dynamics. However, how these MT tips stabilized remains poorly understood. Here, we report that centrosome spindle pole protein 1 (CSPP1) caps stabilizes both plus minus static MTs. Real-time imaging laser-ablated live cells showed deposition CSPP1 at newly generated ends, whose...
Error-free cell division depends on the accurate assembly of spindle midzone from dynamic microtubules to ensure chromatid segregation during metaphase-anaphase transition. However, mechanism underlying key transition mitotic central before anaphase onset remains elusive. Given prevalence chromosome instability phenotype in gastric tumorigenesis, we developed a strategy model context-dependent using combination light sheet microscope and 3D organoids. Light microscopic image analyses...
Heterochromatin protein 1α (HP1α) regulates chromatin specification and plasticity during cell fate decision. Different structural determinants account for HP1α localization function division cycle. Our earlier study showed that centromeric of depends on the epigenetic mark H3K9me3 in interphase, while its location mitosis relies uncharacterized PXVXL-containing factors. Here, we identified a protein, ligand-dependent nuclear receptor-interacting factor 1 (LRIF1), which recruits to...
Stable transmission of genetic information during cell division requires faithful mitotic spindle assembly and chromosome segregation. In eukaryotic cells, nuclear envelope breakdown (NEBD) is required for proper Although a list kinases has been implicated in NEBD, how they coordinate their activity to dissolve the protein machinery such as pore complexes was unclear. Here, we identified regulatory mechanism which Nup62 acetylated by TIP60 human division. novel substrate TIP60, acetylation...
Abstract Cell polarity is essential for spatially regulating of physiological processes in metazoans by which hormonal stimulation‒secretion coupling precisely coupled tissue homeostasis and organ communications. However, the molecular mechanisms underlying epithelial cell establishment remain elusive. Here, we show that septin cytoskeleton interacts with catenin complex to organize a functional domain separate apical from basal membranes polarized cells. Using monolayer as model system...
Microencapsulation of pesticides is a promising attempt to reduce environmental pollution and prevent the active ingredients from interference external factors. In this paper, pendimethalin microcapsules were prepared by interfacial polymerization 4,4-methylenediphenyl diisocyanate (MDI) ethylenediamine (EDA) based on microfluidic technology. Effects microchannel structure, reaction temperature, surfactant type, fluid flow rates investigated evaluated. The results showed that under suitable...
ABSTRACT Error-free mitosis depends on accurate chromosome attachment to spindle microtubules via a fine structure called the centromere that is epigenetically specified by enrichment of CENP-A nucleosomes. Centromere maintenance during requires CENP-A-mediated deposition constitutive centromere-associated network establishes inner kinetochore and connects centromeric chromatin mitosis. Although previously proposed be an adaptor retinoic acid receptor, here, we show CENP-R synergizes with...
A new highly oxygenated germacranolide, carcerlane (1), together with four known germacranolides (2-5), was isolated from an ethanol extract of the whole plant Carpesium nepalense var. lanatum (C.B.Clarke) Kitam. The structures were determined by HRESIMS and extensive analysis their spectroscopic data including IR, 1 D 2 NMR spectra. To our best knowledge, it first time to report phytochemical investigation on this plant. anti-Alzheimer's disease (AD) activities 1-5 evaluated using...
Background: Cassia obtusifolia is a traditional Chinese medicine used in lowering blood lipids, but the specific compounds and mechanisms responsible for this action are still unknown. Anthraquinones primary active components of C. obtusifolia, among which 1,8-dihydroxyanthraquinone (DHAQ) exhibits strong biological activities. Aim: The effects DHAQ on lipids underlying were investigated study to provide reliable experimental basis development application obtusifolia. Materials Methods: Mice...
Abstract In mammals, the transcription of transposable elements (TEs) is important for maintaining early embryonic development. Here, we systematically analyzed expression characteristics TE-derived transcripts in embryos by constructing a database TEs and transcriptome data from goats using it to study function endogenous retroviruses (ERVs) regulating embryo We found that ERV1 made up highest proportion TE sequences exhibited stage-specific pattern during Among ERV elements, had potential...