A5011700575- Ultrasound and Hyperthermia Applications
- MicroRNA in disease regulation
- Microtubule and mitosis dynamics
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Advanced SAR Imaging Techniques
- Seaweed-derived Bioactive Compounds
- Aquaculture Nutrition and Growth
- DNA Repair Mechanisms
- Ovarian cancer diagnosis and treatment
- Hydrogen's biological and therapeutic effects
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Advanced Proteomics Techniques and Applications
- Protist diversity and phylogeny
- Surgical Simulation and Training
- Plant Molecular Biology Research
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Image and Signal Denoising Methods
- 3D Printing in Biomedical Research
- Glycosylation and Glycoproteins Research
- Genomics and Chromatin Dynamics
- Echinoderm biology and ecology
- Advanced Nanomaterials in Catalysis
- Anatomy and Medical Technology
Nanjing Medical University
2020-2024
Morehouse School of Medicine
2021
University of Science and Technology of China
2015-2021
Fudan University
2014-2021
Tianjin University
2020
Center for Excellence in Molecular Cell Science
2019
Xinjiang Medical University
2017
First Affiliated Hospital of Xinjiang Medical University
2017
Ocean University of China
2013
The spindle assembly checkpoint (SAC) is a conserved signaling pathway that monitors faithful chromosome segregation during mitosis. As core component of SAC, the evolutionarily kinase monopolar 1 (Mps1) has been implicated in regulating alignment, but underlying molecular mechanism remains unclear. Our delineation Mps1 activity SAC led to discovery previously unidentified structural determinant function at kinetochores. Here, we show contains an internal region for kinetochore localization...
Error-free cell division depends on the accurate assembly of spindle midzone from dynamic microtubules to ensure chromatid segregation during metaphase-anaphase transition. However, mechanism underlying key transition mitotic central before anaphase onset remains elusive. Given prevalence chromosome instability phenotype in gastric tumorigenesis, we developed a strategy model context-dependent using combination light sheet microscope and 3D organoids. Light microscopic image analyses...
Stable transmission of genetic material during cell division requires accurate chromosome segregation. PLK1 dynamics at kinetochores control establishment correct kinetochore-microtubule attachments and subsequent silencing the spindle checkpoint. However, regulatory mechanism responsible for activity in prometaphase has not yet been affirmatively identified. Here we identify Apolo1, which tunes attachments. Apolo1 localizes to early mitosis, suppression results misaligned chromosomes. Using...
// Jie Qiao 1, * , Shu-Jian Cui 3, Lei-Lei Xu 1 Si-Jie Chen 4 Jun Yao Ying-Hua Jiang Gang Peng Cai-Yun Fang 2 Peng-Yuan Yang 2, Feng Liu Department of Medical Systems Biology School Basic Sciences and Institutes Biomedical Sciences, Fudan University, Shanghai 200032, China Chemistry, 200433, 3 College Bioscience Biotechnology, Key Laboratory Crop Genetics Physiology Jiangsu Province, Yangzhou 225009, China. Brain Science, These authors contributed equally to this work Correspondence to: Liu,...
BACKGROUND: Laparoscopic and robotic-assisted techniques have gained popularity, endometrial cancer (EC) remains a significant health problem among women. OBJECTIVE: Minimally invasive surgical (MIS) therapy options for early will be evaluated their effectiveness safety is the aim of this paper. We also investigate differences in oncologic outcomes between MIS open surgery (OS) individuals with early-stage EC. The patient was diagnosed EC treated laparoscopic focus retrospective analysis....
The application of ultrasound and microbubbles (USMB-) mediated microRNA (miR) is a promising approach gene delivery for cancer treatment. We aimed to discuss the effects USMB-miR-505 on cervical (CC) development. miR-505 by USMB was prepared. effect its transfection efficiency HeLa cell proliferation, cycle, apoptosis, migration, invasion were studied. target predicted, expression in CC detected. cells further verified. showed higher than alone. inhibitory better miR-505. targeted AKT2,...
Endometrial carcinoma (EC) is an epithelial malignant tumor that occurs in the endometrium. It of great significance to explore new targets for improving prognosis endometrial cancer. Chikusetsusaponin Iva (CHI) a plant compound extracted from Panacis japonica which has multiple biological activities, including anti-inflammation and anti-tumor effects. However, its possible effects on EC are unclear. Herein, we found CHI inhibited cell proliferation cycle, confirmed by colony formation flow...
The inherent magnitude and phase errors between channels in the multichannel synthetic aperture radar/ground moving target indication (SAR/GMTI) system will affect clutter suppression detection performance of system. To solve this problem, letter proposes an adaptive channel balancing algorithm based on 2-D Gaussian kernel function. First, iterative reweighted least squares (IRLS) is used to estimate compensate linear error that varies with Doppler frequency range-Doppler domain. Then...
To discuss the effect of three-dimensional (3D) printing individualized model and guide plate in bone tumor surgery.
Abstract Background: The gene-loaded microbubbles (MBs) combined with ultrasound resulting in increased delivery efficiency, may be a novel method of gene delivery. We explored the effects and (USMB)-mediated microRNA (miR)-505 on cervical cancer (CC) development. Methods: miR-505 mediated by USMB was prepared. effect its transfection efficiency studied RT-qPCR. HeLa cell proliferation evaluated MTT colony formation assays. Flow cytometry used to study cycle changes, Hoechst utilized detect...
Abstract The authors have withdrawn this preprint due to erroneous posting.
Multi-channel moving target detection algorithm is an essential technique for ground indication (GMTI). The inconsistency of magnitude and phase characteristics between channels will affect the clutter suppression effect Synthetic Aperture Radar (SAR) system, thus final performance detection. To solve this problem, a channel balance based on two-dimensional Gaussian kernel function [1] non-local means (NLM) filter proposed in paper. Firstly, error estimated compensated by image domain, then...