A5101682993- Neuroinflammation and Neurodegeneration Mechanisms
- Probiotics and Fermented Foods
- HIV Research and Treatment
- Infant Nutrition and Health
- Gut microbiota and health
- interferon and immune responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Silk-based biomaterials and applications
- Inflammasome and immune disorders
- S100 Proteins and Annexins
- Virus-based gene therapy research
- Escherichia coli research studies
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
Southern Medical University
2017-2020
It has long been known that probiotics can be used to maintain intestinal homeostasis and treat a number of gastrointestinal disorders, but the underlying mechanism remained obscure. Recently, increasing evidence supports notion certain probiotic-derived components, such as bacteriocins, lipoteichoic acids, surface layer protein secreted protein, have similar protective role on barrier function live probiotics. These bioactive components named 'postbiotics' in most recent publications. We...
Abstract The objective of this study was to determine whether Lactobacillus rhamnosus GG culture supernatant (LCS) has a preventive effect against gut-derived systemic neonatal Escherichia coli (E. ) K1 infection. effects were evaluated in human colonic carcinoma cell line Caco-2 and rat models. Our vitro results showed that LCS could block adhesion, invasion translocation E. monolayer via up-regulating mucin production maintaining intestinal integrity. In vivo experiments revealed...
Bacterial infection remains one of the leading causes death worldwide due to continuous rise multiple antibiotic-resistant bacteria. Focusing solely on bacteria as drug targets is a major limitation inherent in conventional antibiotic therapy. Recently, host-directed therapies have become such an innovative approach modulate host defense system and interplay innate adaptive immunity. Our previous studies showed that memantine (MEM), α7 nAChR antagonist, could efficiently block multi-drug...
Objective To investigate the role of HIV-1 envelope protein gp120 in cognitive impairment induced by neuronal damage. Methods Western blot and immunofluorescence assay were used to detect microglia activation, inflammatory factor expression damage after treatment. Neuronal neurocognitive performance gp120-transgenic mice evaluated using immunohistochemical staining behavioral analysis, respectively. Results In vivo vitro experiments showed that significantly caspase-1 IL-1β,...
To construct a HIV-1 gp120 transgenic mice (gp120 Tg) with vimentin (VIM) gene knockout.Female Tg were mated to VIM heterozygote (F0). All the offspring derived from these original founders so that both genotypes had same mixed genetic background. The F1 bred generate of VIM+/+, VIM-/-, VIM+/+/gp120 and VIM-/-/gp120 mice. PCR was performed for genotyping mice, expressions in brain tissues examined using immunoblotting.The results showed presence target bands In expression detected throughout...