Role of HIV-1 envelope protein gp120 in neuronal injury-induced cognitive impairment

• DOI: 10.3760/cma.j.issn.0254-5101.2020.01.006
• Publication Date: 2020-01-31
• Authors: Yu Wan; Weijun Yang; Zelong Gong; Zhijie Zeng; Hanyun Zhang; Keyao Lyu
• Keywords: Neurocognitive; Immunofluorescence; Brain damage

Objective To investigate the role of HIV-1 envelope protein gp120 in cognitive impairment induced by neuronal damage.

Methods Western blot and immunofluorescence assay were used to detect microglia activation, inflammatory factor expression damage after treatment. Neuronal neurocognitive performance gp120-transgenic mice evaluated using immunohistochemical staining behavioral analysis, respectively.

Results In vivo vitro experiments showed that significantly caspase-1 IL-1β, indirectly caused synaptic shortening (P<0.05). Compared with wild-type mice, significant cortical hippocampal glial loss, dendritic disorders.

Conclusions HIV-1 might cause through activating release involve impairment.

Key words: HIV-1; gp120; Cognitive impairment; gp120-transgenic mouse; Microglia