A5003686695- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Gastroesophageal reflux and treatments
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Eosinophilic Esophagitis
- Lipid metabolism and disorders
- Platelet Disorders and Treatments
- Extracellular vesicles in disease
- Glioma Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Gastrointestinal motility and disorders
- Intracranial Aneurysms: Treatment and Complications
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Animal Virus Infections Studies
- Nutrition and Health in Aging
- COVID-19 epidemiological studies
- Systemic Sclerosis and Related Diseases
- Cancer, Lipids, and Metabolism
- Cerebrovascular and Carotid Artery Diseases
- Esophageal and GI Pathology
Tianjin Third Central Hospital
2017-2025
Tianjin Medical University
2017-2025
Ruijin Hospital
2024-2025
Tongji Hospital
2021-2024
Tongji University
2022-2024
Tianjin Hospital
2022
Tianjin Fire Research Institute
2017
ABSTRACT Objectives Intracranial aneurysm (IA) poses a significant health risk, and its formation involves various factors, including lipid metabolism, while former research only focused on the standard lipid. The purpose of this study is to explore 179 variants' impact unruptured intracranial aneurysms (uIA). Materials Methods Utilizing GWAS data for lipids uIAs, MR analyses were employed with pleiotropy, heterogeneity, sensitivity tests. Reverse then conducted. Results revealed seven...
Patients with acute-on-chronic liver failure (ACLF) have a high mortality rate, poor prognosis, and often experience concurrent thrombocytopenia bleeding events. To evaluate the efficacy safety of recombinant human thrombopoietin (rhTPO) in patients ACLF concomitant severe thrombocytopenia. This was prospective, open-label study. We assigned 70 into rhTPO group control group, 35 each group. received subcutaneous injections at dose 15000 IU/day for 7 consecutive days, while did not receive...
We aimed to investigate sleep quality, mild hepatic encephalopathy, anxiety, and depression in patients with hepatitis B cirrhosis by using a variety of scales questionnaires.A cohort 341 liver were categorized Child-Pugh grading (A, B, C) this cross-sectional study. Pittsburgh Sleep Quality Index (PSQI), Number Connection Test-A (NCT-A), Hospital Anxiety Depression (HAD) evaluated the questionnaires statistically analyzed intrinsic correlation. The control group included 50 healthy...
This study employed Mendelian randomization (MR) analysis to systematically investigate the potential connections between gut microbiota and risk of glioblastoma (GBM). We identified 12 microbial groups closely associated with incidence GBM. Subsequently, MR was conducted on 1,091 blood metabolites 309 metabolite ratios, revealing 19 that exert an impact occurrence Hypothesizing may influence multiforme by modulating these metabolites, we performed analyses, considering each group as...
Aim The present study aimed to evaluate the durability of immune response after basic and booster immunization with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients chronic liver disease (CLD). Methods Patients CLD complete or SARS-CoV-2 were included this study. Based on vaccination situation, they divided into immunity group (Basic) (Booster), which then subdivided four groups according time interval from completion serological specimen collection. positive...
Abstract Numerous studies have explored the various functions of SLC40A1 in cancer development. However, role primary glioblastoma necessitates further investigation. Initially, we observed that GBM patients with high expression had a more favorable prognosis compared to those low levels, as evidenced by analysis TIMER database. Subsequent using TCGA database enabled us identify potential mechanisms. Further analyses, including GO, KEGG, GSEA, immune infiltration, and correlation revealed...
Abstract Aim we examined the humoral immune response and antibody dynamics after primary booster vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among patients with chronic liver disease (CLD). Methods We enrolled confirmed CLD SARS-CoV-2 or immunity. Following immunity, serological samples were gathered to detect novel neutralizing antibodies (nCoV NTAb) spike receptor-binding proteins S-RBD). Results The positive rate of nCoV NTAb was 60.1% in Primary 87.6%...
Background Cases of duodenal variceal hemorrhage after cirrhosis are rare, but patients have a higher mortality rate. There is currently no clinical guideline to address how such should choose preferred treatment. Methods We retrospectively evaluated the information 65-year-old male admitted Gastroenterology Department with gastrointestinal bleeding. Results The patient was eventually diagnosed bleeding cirrhosis. performed TIPS on vital signs were stable. No varicose veins seen by endoscopy...
ABSTRACT This article is aim to investigate the safety and immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine booster in patients with chronic liver disease(CLD). A total 114 CLD who received a SARS-CoV-2 were enrolled this study. Serum samples collected from at least 14 days after dose tested for neutralizing antibody (novel antibody, nCoV NTAb) IgG against spike binding domain receptor-binding S-RBD antibody) levels. The positive rates NTAb 87.72%...
The high prevalence and incidence of non-alcoholic fatty liver disease (NAFLD) have become a global medical concern. Compared with obesity, metabolic abnormalities may be more critical. Currently, there is lack relevant data for nutritional status energy characteristics in patients obese lean NAFLD.