A5100690673- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Immune cells in cancer
- Immune Cell Function and Interaction
- Heat shock proteins research
- Melanoma and MAPK Pathways
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- Adipose Tissue and Metabolism
- Cancer Immunotherapy and Biomarkers
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Natural product bioactivities and synthesis
- Clusterin in disease pathology
- HER2/EGFR in Cancer Research
- Epigenetics and DNA Methylation
- Medicinal Plants and Bioactive Compounds
- Endoplasmic Reticulum Stress and Disease
- Growth Hormone and Insulin-like Growth Factors
- RNA Research and Splicing
- Bladder and Urothelial Cancer Treatments
- Toxin Mechanisms and Immunotoxins
- Bee Products Chemical Analysis
German Cancer Research Center
2022-2024
Heidelberg University
2022-2024
Helmholtz Institute Mainz
2022
Johannes Gutenberg University Mainz
2022
Zhongnan Hospital of Wuhan University
2022
Wuhan University
2022
Jinan University
2019-2020
North China University of Science and Technology
2020
Nantong University
2019
Affiliated Hospital of Nantong University
2019
CD4 + regulatory T (T reg ) cells accumulate in the tumor microenvironment (TME) and suppress immune system. Whether how metabolite availability TME influences cell differentiation is not understood. Here, we measured 630 metabolites found that serine palmitic acid, substrates required for synthesis of sphingolipids, were enriched. A serine-free diet or a deficiency Sptlc2, rate-limiting enzyme catalyzing sphingolipid synthesis, suppressed accumulation inhibited growth. Sphinganine, an...
Mounting evidence has illustrated the vital roles of long non-coding RNAs (lncRNAs in gastric cancer (GC). Nevertheless, majority their and mechanisms GC are still largely unknown. In this study, we investigate lncRNA SLC25A5-AS1 on tumourigenesis explore its potential GC. The results showed that expressions were significantly lower than adjacent normal tissues, which associated with tumour size, TNM stage lymph node metastasis. Moreover, could inhibit cell proliferation, induce G1/G1 cycle...
Abstract Metastasis is the main factor of treatment failure in cancer patients, but underlying mechanism remains to be elucidated and effective new strategies are urgently needed. This study aims explore novel key metastasis-related microRNAs (miRNAs) esophageal squamous cell carcinoma (ESCC). By comparing miRNA profiles highly metastatic ESCC sublines, we established through serial vivo selection with parental cells, found that expression level miR-515-3p was lower tumor tissues than...
Ubiquitin C-terminal hydrolase L5 (UCHL5) is a deubiquitinating enzyme (DUB) that removes ubiquitin from its substrates. Associations between UCHL5 and cancer have been reported in various tissues, but the effect of on bladder has not thoroughly investigated. This study investigates expression function cancer. was shown to be abnormally expressed using IHC tissue microarray Western blotting. Several procedures were performed assess overexpression or knockdown cancer, such as cell...
No AccessJournal of UrologyInvestigative Urology1 Jul 2005LOW DOSE SURAMIN AS A CHEMOSENSITIZER OF BLADDER CANCER TO MITOMYCIN C YAN XIN, GREG LYNESS, DANNY CHEN, SAEHEUM SONG, M. GUILLAUME WIENTJES, and JESSIE L.-S. AU XINYAN XIN , LYNESSGREG LYNESS CHENDANNY CHEN SONGSAEHEUM SONG WIENTJESM. WIENTJES AUJESSIE View All Author Informationhttps://doi.org/10.1097/01.ju.0000161594.86931.eaAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...
Background Mounting evidence has demonstrated that an imbalance in liquid–liquid phase separation (LLPS) can induce alteration the spatiotemporal coordination of biomolecular condensates, which plays a role carcinogenesis and cachexia. However, LLPS occurrence progression bladder cancer (BLCA) remains to be elucidated. Identifying may aid therapeutics. Methods A total 1,351 BLCA samples from six cohorts were retrieved publicly available databases like The Cancer Genome Atlas, Gene Expression...
Mitochondria are involved in many crucial cellular processes. Maintaining healthy mitochondria is essential for homeostasis. Parkin-dependent mitophagy plays an important role selectively eliminating damaged mammalian cells. However, mechanisms of remain elusive. In this research, we performed data-independent acquisition-based quantitative mitochondrial proteomics to study the proteomic alterations carbonyl cyanide m-chlorophenylhydrazone (CCCP)-induced Parkin-mediated mitophagy. We...
Background . To explore the activity of Modified Tongyou Decoction (MTD) against Eca109 esophageal cancer (EC) cell invasion and metastasis to ascertain mechanism its anticancer during epithelial‐mesenchymal transition (EMT) as mediated by HIF‐1 α ‐Snail axis. Methods Herbal compounds were prepared ethanol extraction, 6 herbs composing into MTD dipped in water‐free filtered. The filtrate was collected centrifuged. remains concentrated a paste which adjusted 5000mg/mL concentration with DMSO....
Lung cancer is one of the most prevalent malignancies in world. The 5-year survival rate for non-small cell lung (NSCLC) patients only approximately 15%, with metastasis as primary cause death. This study was aimed to investigate cytotoxic effect external qi Yan Xin Qigong (YXQ-EQ) toward human adenocarcinoma A549 cells well its on signaling pathways promoting migration, invasion and epithelial-to-mesenchymal transition (EMT) cells.Cytotoxic YXQ-EQ evaluated using MTS...