A5079219349- Viral Infections and Immunology Research
- Biological Activity of Diterpenoids and Biflavonoids
- Natural product bioactivities and synthesis
- RNA and protein synthesis mechanisms
- interferon and immune responses
- Bioactive Natural Diterpenoids Research
- Cytomegalovirus and herpesvirus research
- CRISPR and Genetic Engineering
- Immune Response and Inflammation
- Inflammatory Bowel Disease
- RNA regulation and disease
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- Virus-based gene therapy research
- Bioactive natural compounds
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- Growth Hormone and Insulin-like Growth Factors
- Phytochemical compounds biological activities
- Fungal Plant Pathogen Control
- Immune Cell Function and Interaction
- Phytochemistry and biological activity of medicinal plants
- Cancer and Skin Lesions
- Pleural and Pulmonary Diseases
First Hospital of Jilin University
2014-2025
Jilin University
2014-2025
Soochow University
2024
First Affiliated Hospital Zhejiang University
2019-2020
Zhejiang University
2008-2019
International Paper (United States)
2017
Nanjing University of Chinese Medicine
2011-2016
Institute of Virology of the Slovak Academy of Sciences
2015
Jilin Medical University
2015
Shenyang Pharmaceutical University
2007-2008
Many viruses disrupt the host cell cycle to facilitate their own growth. We assessed mechanism and function of enterovirus 71 (EV71), a primary causative agent for recent hand, foot, mouth disease outbreaks, in manipulating progression. Our results suggest that EV71 infection induces S-phase arrest diverse types by preventing transition from S phase into G2/M phase. Similar were observed an alternate picornavirus, Coxsackievirus A16. Synchronization phase, but not G0/G1 or promotes viral...
Abstract SAMHD 1 possesses multiple functions, but whether cellular factors regulate expression or its function remains not well characterized. Here, by investigating why cultured RD and HEK 293T cells show different sensitivity to enterovirus 71 (EV71) infection, we demonstrate that is a restriction factor for EV71. Importantly, identify TRIM 21, an E3 ubiquitin ligase, as key regulator of 1, which specifically interacts degrades through the proteasomal pathway. However, 21 has no effect on...
Recent epidemiological data indicate that outbreaks of hand, foot, and mouth disease (HFMD), which can be categorized according to its clinical symptoms as typical or atypical, have markedly increased worldwide. A primary causative agent for HFMD outbreaks, enterovirus 71 (EV71), has been shown manipulate the cell cycle in S phase own replication; however, it is not clear whether coxsackievirus (CVA6), main atypical HFMD, also regulates host cycle. In this study, we demonstrate first time...
Previous studies demonstrate that human enterovirus 71 (EV71), a primary causative agent for hand, foot, and mouth disease, activates caspase-3 through the non-structural viral 3C protein to induce host cell apoptosis; however, until now it was unclear how activation affects production. Our results binds caspase-8 caspase-9 but does not directly bind activate them, proteolytic activity of is required by caspase-8, caspase-3. Inhibition attenuates apoptosis in 3C-transfected cells....
Primary squamous cell carcinoma of the thyroid is a rare and aggressive type neoplasm, which routinely treated with surgery; however, despite this, survival time not commonly more than six months. Thus, aim present study was to determine efficacy pseudolaric acid (PAB) as therapeutic agent. PAB an antitubulin agent, in study, inhibition SW579 line by investigated. found inhibit growth time‑ dose‑dependent manner via interference α‑tubulin polymerization. However, inhibitory role cells...
Coxsackievirus A16 (CA16) is one of the main causative pathogens hand, foot and mouth disease (HFMD). Viral replication typically results in host cell apoptosis. Although CA16 infection has been reported to induce apoptosis human rhabdomyosarcoma (RD) line, it remains unclear whether induces diverse types, especially neural cells which have important clinical significance. In current study, was found similar apoptotic responses both non-neural vitro, including nuclear fragmentation, DNA...
Pseudolaric acid B (PAB) has been demonstrated to exert antitumor effects in MCF-7 human breast cancer cells. The present study aimed investigate the mechanism of resistance PAB-induced cell death. Following incubation with 4 µM PAB for 3 days, majority cells became senescent, while some retained same morphology as control cells, assessed using a senescence detection kit. Additionally, 36 h treatment increased positive staining autophagy markers, shown by monodansylcadaverine and acridine...
Coxsackievirus A6 (CV-A6) is a major emerging pathogen associated with atypical hand, foot, and mouth disease can cause serious complications such as encephalitis, acute flaccid paralysis, neurorespiratory syndrome. Therefore, revealing the pathogenic mechanisms could benefit control of CV-A6 infections. In this study, we demonstrate that nonstructural 2CCV-A6 suppresses IFN-β production, which supports infection. This achieved by depleting RNA sensors melanoma differentiation-associated...
Human enterovirus 68 (EVD68) is a primary causative agent for respiratory illness worldwide. Until now, there has been no available medication treating EVD68-related diseases. Rheum emodin, artemisinin, astragaloside, pseudolaric acid B, oridonin, and erianin are natural extracts from Chinese herbs that have traditionally used the treatment prevention of epidemic Our results showed B protected cells EVD68-induced cytopathic effects decreased viral production. However, same were not observed...
Tenascin-C (TNC) is an extracellular matrix glycoprotein expressed in response to inflammation and tissue damage. The role of TNC patients with inflammatory bowel disease (IBD) not well understood. In this study, we analyzed the expression inflamed mucosa ulcerative colitis (UC) Crohn’s (CD). Serum levels were determined by enzyme-linked immunosorbent assay (ELISA), different activities compared. was derived from a GEO dataset. THP-1 cells stimulated evaluate proinflammatory TNC. We found...
Hand, foot, and mouth disease (HFMD) is a febrile exanthematous with typical or atypical symptoms. Typical HFMD usually caused by enterovirus 71 (EV71) coxsackievirus A16, while A6 (CA6). In recent years, worldwide outbreaks of CA6-associated have dramatically increased, although the pathogenic mechanism CA6 still unclear. EV71 has been established to induce caspase-dependent apoptosis, but in this study, we demonstrate that infection promotes distinct pathway cell death involves loss...