A5106571365- Pregnancy and preeclampsia studies
- Biological Activity of Diterpenoids and Biflavonoids
- Reproductive System and Pregnancy
- Viral Infections and Immunology Research
- Gestational Diabetes Research and Management
- Natural product bioactivities and synthesis
- Bioactive Natural Diterpenoids Research
- Atherosclerosis and Cardiovascular Diseases
- MicroRNA in disease regulation
- Glutathione Transferases and Polymorphisms
- RNA regulation and disease
- Reproductive Biology and Fertility
- Viral gastroenteritis research and epidemiology
- Spine and Intervertebral Disc Pathology
- Thyroid Cancer Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ovarian function and disorders
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Alcohol Consumption and Health Effects
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Ginseng Biological Effects and Applications
Zoucheng People's Hospital
2013-2021
Union Hospital
2018-2021
Huazhong University of Science and Technology
2018-2021
First Hospital of Jilin University
2015-2018
Jilin University
2015-2018
Linyi People's Hospital
2018
Jilin Medical University
2015
Abstract Preeclampsia is a serious complication of pregnancy and leads to maternal hypertension proteinuria. It remains major health problem for mothers babies across the world due high fetal morbidity mortality. Accumulated data have implicated critical role microRNA in preeclampsia. However, date, miR‐548c‐5p preeclampsia vaguely understood. In this study, we first elucidate its underlying molecular mechanism Compared with healthy controls, was obviously downregulated serum exosomes...
Many viruses disrupt the host cell cycle to facilitate their own growth. We assessed mechanism and function of enterovirus 71 (EV71), a primary causative agent for recent hand, foot, mouth disease outbreaks, in manipulating progression. Our results suggest that EV71 infection induces S-phase arrest diverse types by preventing transition from S phase into G2/M phase. Similar were observed an alternate picornavirus, Coxsackievirus A16. Synchronization phase, but not G0/G1 or promotes viral...
Recent epidemiological data indicate that outbreaks of hand, foot, and mouth disease (HFMD), which can be categorized according to its clinical symptoms as typical or atypical, have markedly increased worldwide. A primary causative agent for HFMD outbreaks, enterovirus 71 (EV71), has been shown manipulate the cell cycle in S phase own replication; however, it is not clear whether coxsackievirus (CVA6), main atypical HFMD, also regulates host cycle. In this study, we demonstrate first time...
MicroRNA (miRNA) has been widely suggested to play a vital role of in the pathogenesis gestational diabetes mellitus (GDM). We have previously demonstrated that miR-657 can regulate macrophage inflammatory response GDM. However, on M1/M2 polarization GDM is not clear yet. This study aimed at elucidating this issue and identifying novel potential therapeutic targets based miRNA network. found be upregulated placental macrophages by real-time PCR, which enhance proliferation migration vitro....
We performed a systematic review of genome‐wide gene expression datasets to identify key genes and functional modules involved in the pathogenesis systemic lupus erythematosus (SLE) at systems level. Genome‐wide involving SLE patients were searched Gene Expression Omnibus ArrayExpress databases. Robust rank aggregation (RRA) analysis was used integrate those public associated with SLE. The weighted coexpression network (WGCNA) adapted pathogenesis, ontology enrichment utilized explore their...
Previous studies demonstrate that human enterovirus 71 (EV71), a primary causative agent for hand, foot, and mouth disease, activates caspase-3 through the non-structural viral 3C protein to induce host cell apoptosis; however, until now it was unclear how activation affects production. Our results binds caspase-8 caspase-9 but does not directly bind activate them, proteolytic activity of is required by caspase-8, caspase-3. Inhibition attenuates apoptosis in 3C-transfected cells....
To investigate the incidence of intraoperative blanchable erythema and pressure injuries in patients undergoing digestive surgery to explore potential risk factors.Pressure pose significant economic healthcare burden are used as one key indicators nursing operation room with high incidence.A retrospective observational study.Basic information results 3S assessment scale injury were obtained from system. And or followed up for 72 hr by The clinical data collected analyse factors univariate...
The role of microRNA (miRNA) in gestational diabetes mellitus has been widely investigated during the last decade. However, altering effect miR-6869-5p on immunity and placental microenvironment is largely unknown. In our study, expression was documented to be significantly decreased placenta-derived mononuclear macrophages, which also negatively related PTPRO. Besides, PTPRO regulated by macrophages. vitro, inhibited macrophage proliferation demonstrated EdU CCK-8 experiments. inflammatory...
Pseudolaric acid B (PAB) has been demonstrated to exert antitumor effects in MCF-7 human breast cancer cells. The present study aimed investigate the mechanism of resistance PAB-induced cell death. Following incubation with 4 µM PAB for 3 days, majority cells became senescent, while some retained same morphology as control cells, assessed using a senescence detection kit. Additionally, 36 h treatment increased positive staining autophagy markers, shown by monodansylcadaverine and acridine...
Autophagy and apoptosis are closely associated. In previous studies, pseudolaric acid B (PAB), a diterpene isolated from the root trunk bark of Pseudolarix kaempferi Gordon (Pinaceae), was demonstrated to induce in various cell lines. However, L929 murine fibrosarcoma SW579 human thyroid squamous carcinoma cells, only autophagy induced. present study, another line, MRC5 lung fibroblast identified which PAB induced autophagy. The relationship between subsequent treatment cells explored. When...
Pulmonary arterial hypertension (PAH) is a complex and severe complication of connective tissue disease (CTD). We aimed to evaluate the application value myocardial perfusion imaging (MPI) in evaluating CTD-associated PAH (CTD-PAH).We retrospectively included 88 patients who were diagnosed with CTD between January 2018 December 2020 at our hospital. Fifty-eight had into CTD-PAH group. Thirty without control All received routine physical examination, biochemical tests cardiac function...
Objective To explore the effect of epidural adhesion lysis with special catheter via sacral canal in treatment patients lumbar intervertebral disc herniation. Methods Thirty-five herniation were enrolled study, aged 25-72 yr, male 20 cases, female 15 cases. All received canal. Visual analogue scale (VAS) and Oswestry disability index (ODI) applied to evaluate at one week six months after treatment. The complications recorded. Results VAS ODI decreased singnificantly (2.6±1.5) ,...