A5101602605- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Ultrasound and Hyperthermia Applications
- Ocular Surface and Contact Lens
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Multiple Sclerosis Research Studies
- Pancreatic function and diabetes
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Connexins and lens biology
- Neonatal Respiratory Health Research
- Lymphatic System and Diseases
- Intraocular Surgery and Lenses
- Parasitic Diseases Research and Treatment
- CRISPR and Genetic Engineering
- Reproductive tract infections research
- Polydiacetylene-based materials and applications
- Ocular Disorders and Treatments
- Dermatological diseases and infestations
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Medicinal Plants and Bioactive Compounds
- Body Image and Dysmorphia Studies
- Bird parasitology and diseases
Chongqing Medical University
2021-2025
Sun Yat-sen University
2010-2024
Third Affiliated Hospital of Sun Yat-sen University
2009-2024
Zhejiang University of Technology
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2022
Institute of Biomedical Science
2019
Peking Union Medical College Hospital
2019
Wuhan University
2009
To investigate the distribution of diabetic retinopathy (DR) by sex in patients with type 2 diabetes mellitus (T2DM) a twelve-province cross-sectional study China. Patients T2DM, whose ages were ≥18 years, recruited from 76 cities/counties 12 provinces mainland China between January 2015 and December 2018. All participants received standardized interview, eye examinations, digital fundus photography. The presence severity DR diagnosed classified retina specialists according to domestic...
The pathogenesis of premature ovarian insufficiency (POI) not only affects the structure and function but also gives rise to complications such as osteoporosis dyslipidemia. Although low-intensity pulsed ultrasound (LIPUS) has been proven effective in treating POI, its impact on associated remains unexplored. Therefore, this study aims investigate effects LIPUS irradiation dyslipidemia a mouse model POI.
The endocannabinoid signalling (ECS) system has been known to regulate glucose homeostasis. Previous studies have suggested that the cannabinoid 2 (CB2) receptor may play a regulatory role on insulin secretion, immune modulation and resistance. Given diabetes resistance are attributable elevated inflammatory tone, we investigated of CB2 tolerance sensitivity in high-fat diet (HFD)/streptozotocin (STZ)-induced mice.Diabetes was induced male ICR mice by HFD/STZ exposed agonist, SER601, for 2-...
Islet transplantation is one of the most promising therapeutic options that could restore euglycaemia in type 1 diabetic individuals. The currently implemented alginate microsphere islet encapsulation approach has led to positive outcomes improving intraportal delivery rodents. However, results obtained from human clinical trials remain disappointing. less than satisfactory outcome mainly attributable increased size encapsulated and alginate-elicited host immune responses. In order achieve...
Purpose: To explore whether CCR7–CCL19 and CCR7-CCL21 affect the pathophysiology of dry eye disease (DED) immuno-inflammatory response using a murine model.Methods: The mRNA expression levels CCR7, CCL19, CCL21 VEGF-C within corneas in DED mice were detected by real-time PCR. Immunofluorescence flow cytometric analyses performed to mark dendritic cells (DCs) detect correlations among lymphatic vessels.Results: CCL19 was dramatically increased during development DED. In addition, which is...
Studies investigating efficacy and safety of bevacizumab in pterygium have increased reported controversial results. Thus, we updated this meta-analysis to clarify the issue. were selected through search databases Embase, PubMed, Web Science, Cochrane Central Register Controlled Trials (CENTRAL) from their inception up until June 2017. The pooled risk ratio (RR) 95% confidence interval (CI) calculated for recurrence complication rates by using random effects model. 1045 eyes 18 randomized...
Prolonged hyperglycemia in diabetes mellitus can result the development of diabetic nephropathy (DN) and increase susceptibility to kidney failure. Low-intensity pulsed ultrasound (LIPUS) is a non-invasive modality that has demonstrated effective tissue repair capabilities. The objective this study was showcase reparative potential LIPUS on renal injury at both animal cellular levels, while also determining optimal pulse length (PL).
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an endogenous peptide with neuroprotective effects on retinal neurons, but the precise mechanism underlying these remains unknown. Considering abundance of mitochondria in ganglion cells (RGCs), we postulate that protective effect PACAP associated regulation mitochondrial function. RGC-5 were subjected to serum deprivation for 48 hours induce apoptosis presence or absence 100 nM PACAP. As revealed Cell Counting Kit-8 assay, at...
Background Bilirubin is the end product of heme catabolism and has strong antioxidant properties. Serum bilirubin levels are reported to be reduced in patients with multiple sclerosis (MS) neuromyelitis optica (NMO). The pathophysiology optic neuritis (ON) resembles that MS; however, role endogenous ON unclear. aim this study measure serum ON, investigate correlation between status bilirubin. Methods were measured 42 50 (MS), 48 (NMO) healthy control subjects. Results total (Tbil), direct...
Bronchopulmonary dysplasia (BPD) is the most prevalent chronic paediatric lung disease and linked to development of obstructive pulmonary disease. MicroRNA-based regulation type II alveolar epithelial cell (T2AEC) proliferation apoptosis an important factor in pathogenesis BPD warrants further investigation.Two murine models hyperoxic injury (with or without miR-342-5p Sprouty-related, EVH1 domain-containing protein 3 [Spred3] modulation) were employed: a hyperoxia-induced acute model (100%...
To explore the inhibitory effects of antivascular endothelial growth factor C (VEGF-C) therapy on corneal lymphangiogenesis and allograft rejection in rats.Fischer 344 rat corneas were transplanted into Lewis eyes. After transplantation, rats (the recipients) randomly equally divided 2 groups: anti-VEGF-C treatment (group A) control B). Corneal hemangiogenesis characterized using whole-mount immunofluorescence, immune grafts was examined a slit lamp evaluated by scoring index (RI). In...
<abstract> <p>In lumbar puncture surgery, compared with the conventional methodologies like computed tomography and magnetic resonance imaging, ultrasound imaging offers advantages of being low cost, no radiation real-time image generation. However, use equipment in involves a cumbersome time-consuming process for subjective overall structure spine order to determine exact point path. Meanwhile, robotic arm system has high precision, good stability simple efficient operation. As...
Objective . To examine conjunctival lymphatic vessels and to analyze the relationship between lymphangiogenesis aggressive recurrent pterygia. Methods Tissues from 60 excised (including 19 of Grade 1, 28 2, 13 3) pterygia were used in study. 9 nasal epibulbar conjunctivae segments as controls. Pterygium slices each patient immunostained with LYVE-1 monoclonal antibodies identify microvessels order calculate lymphovascular area (LVA), microvessel density (LMD), luminal diameter (LVL). The...
Background: Pterygium, a common eye disease with high postoperative recurrence, lacks effective therapeutic strategies. Therefore, it's urgent to identify specific targets develop rationally targeted molecular drugs for the pterygial therapy. Methods: The cell proliferation and motility were studied in both primary human fibroblasts (hPFs) an ex vivo pterygium model. hPFs transfected pCMV3-PDGFRB plasmid, PDGFRB siRNA CRISPR/Cas9 system used determine role of PDGFR-β functions. Western...
Accumulating studies comparing the efficacy and safety of trabeculectomy EX-PRESS implantation in open-angle glaucoma (OAG) report inconsistent findings. Thus, we conducted updated meta-analysis to clarify issue. Randomized controlled trials (RCTs) were selected through search databases PubMed, Web Science, Embase, Cochrane Library from their inception up until November 2018. The pooled mean difference (MD) for intraocular pressure reduction (IOPR) antiglaucoma medication reduction, odds...
We isolated peripheral blood mononuclear cells from a patient diagnosed with early-onset non-syndromic retinitis pigmentosa caused by compound heterozygous mutations in CRB1 (NM_001257965): c.1369C>T (p.R457X) and c.2027C>T (p.T676M). These were transfected four inducible plasmids encoding human OCT4, SOX2, KLF4 or C-MYC together. Transfected induced to form pluripotent stem (iPSCs) expressing the cell markers KLF4, SSEA4 NANOG presenting normal karyotype. could be differentiated into three...
To investigate the effects of low-intensity pulsed ultrasound (LIPUS) on proliferation, differentiation, and tumor necrosis factor-α (TNF-α)-induced lipolysis 3T3-L1 cells, to explore feasibility regulating release free fatty acids (FFA) prevent lipotoxicity.
This study aimed to investigate ocular manifestations in patients with neurosyphilis and their association general indexes.
Polarization and wavelength multiplexed metalenses address the bulkiness of traditional imaging systems. However, despite progress with numerical simulations parameter scanning, engineering complexity classical methods highlights urgent need for efficient deep learning approaches. This paper introduces a learning-driven inverse design model polarization-multiplexed metalenses, employing propagation phase theory alongside spectral transfer to chromatic dispersion challenges. The facilitates...
Abstract The potential of low‐intensity pulsed ultrasound (LIPUS) in regulating ovarian function has been demonstrated; however, there is a lack scientific evidence regarding the long‐term efficacy LIPUS treating injury and understanding its regulatory mechanisms. In this study, 4‐vinylcyclohexene diepoxide (VCD) was used to induce rats, applied target damaged tissues. research aimed investigate protective effect against ovum toxicity induced by VCD elucidate associated molecular During...