A5029008080- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical chemistry methods development
- Traditional Chinese Medicine Analysis
- RNA modifications and cancer
- Cancer-related gene regulation
- Metabolomics and Mass Spectrometry Studies
- Enterobacteriaceae and Cronobacter Research
- Analytical Chemistry and Chromatography
- Epigenetics and DNA Methylation
- Antibiotics Pharmacokinetics and Efficacy
- Electrochemical Analysis and Applications
- Plant-based Medicinal Research
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Cytomegalovirus and herpesvirus research
- Natural product bioactivities and synthesis
- Vibrio bacteria research studies
- Cancer therapeutics and mechanisms
- Bacterial biofilms and quorum sensing
- RNA regulation and disease
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
Jilin University
2021-2025
South China Agricultural University
2020-2025
Ministry of Agriculture and Rural Affairs
2020-2025
Southeast University
2025
Zhongda Hospital Southeast University
2025
Jilin Medical University
2023-2024
Chinese Academy of Sciences
2024
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2024
Changzhou Vocational Institute of Light Industry
2024
Shanghai Ocean University
2019-2023
In an era of increasing concerns about antimicrobial resistance, tigecycline is likely to have a critically important role in the treatment carbapenem-resistant Enterobacteriaceae , most problematic pathogens human clinical settings—especially K. pneumoniae . Here, we identified new plasmid-borne RND-type resistance determinant, TMexCD1-TOprJ1, which widespread among isolates from food animals. tmexCD1-toprJ1 appears originated chromosome Pseudomonas species and may been transferred onto...
We recently identified a novel plasmid-mediated resistance-nodulation-division (RND)-type efflux pump gene cluster, tmexCD1-toprJ1 , in Klebsiella pneumoniae that conferred resistance to multiple antimicrobials, including tigecycline. While homologs of were found encoded many other bacterial species GenBank, their functions and transfer mechanisms remain unknown.
The processing of traditional Chinese medicine (TCM) is a unique pharmaceutical technology in China, which the most important feature that distinguishes from natural and plant medicine. Since record Huangdi Neijing (Inner Canon Yellow Emperor), till now, TCM has experienced more than 2000 years inheritance, innovation, development, combination theory clinical practice, plays an extremely position field TCM. In recent years, as prescription TCM, herbal pieces have played significant role...
ABSTRACT Choerospondias axillaris is a medicinal plant used for treating coronary heart disease (CHD) due to its broad spectrum of anti‐inflammatory activities. Cyclooxygenase 2 (COX‐2) and lipoxygenase 5 (5‐LOX) were immobilized on magnetic nanoparticles selective ligand‐extraction these two enzymes present in C. . Sixteen extracted components identified analyzed using ultraperformance liquid chromatography plus Q‐Exactive Orbitrap tandem mass spectrometry (UHPLC‐Q‐ExactiveOrbitrap‐MS/MS),...
5-Methylcytosine (m 5 C) is one of the major post-transcriptional modifications in mRNA and highly involved pathogenesis various diseases. However, capacity existing assays for accurately comprehensively transcriptome-wide m C mapping still needs improvement. Here, we develop a detection method named DRAM (deaminase reader protein assisted RNA methylation analysis), which deaminases (APOBEC1 TadA-8e) are fused with proteins (ALYREF YBX1) to identify sites through deamination events...
5-Methylcytosine (m 5 C) is one of the post-transcriptional modifications in mRNA and involved pathogenesis various diseases. However, capacity existing assays for accurately comprehensively transcriptome-wide m C mapping still needs improvement. Here, we develop a detection method named DRAM (deaminase reader protein assisted RNA methylation analysis), which deaminases (APOBEC1 TadA-8e) are fused with proteins (ALYREF YBX1) to identify sites through deamination events neighboring sites....
Background: The emergence of linezolid resistance, mediated by genes such as optrA and cfr(D), poses a growing public health threat. While these have been detected in clinical animal-derived Enterococcus species, their presence underexplored species like saccharolyticus remains undocumented, leaving significant gap our understanding dissemination stability. Method: E. GXN23C125Es was screened for the known resistance via PCR analysis. Conjugation stability experiments were used to evaluate...
A novel nanocomposite was successfully applied for magnetic solid phase extraction of heavy metals in environmental water and food samples.
Abstract Objectives To characterize a novel MDR efflux pump gene cluster tnfxB3-tmexCD3-toprJ1b carried by Proteus spp. and Pseudomonas aeruginosa strains from chickens. Methods Antimicrobial susceptibility testing, conjugation WGS were performed to tnfxB3-tmexCD3-toprJ1b-positive isolates. Cloning reverse transcription-quantitative PCR investigate the function of tnfxB3-tmexCD3-toprJ1b. Results The data revealed that cluster, tnfxB3-tmexCD3-toprJ1b, was identified on chromosome cibarius...
The occurrence of transferable tigecycline resistance determinants, tmexCD1-toprJ1, tmexCD2-toprJ2, tmexCD3-toprJ1b, and multiple tet(A) tet(X) variants, presents an unprecedented challenge to clinical therapeutic options. tmexCD-toprJ-like gene clusters can mediate multidrug have been detected in a variety bacteria. Here, we characterized the fourth cluster, tmexCD4-toprJ4, identified on untypeable plasmids Klebsiella quasipneumoniae Enterobacter roggenkampii isolated from chicken meat...
Abstract Background Wucai suffers from low temperature during the growth period, resulting in a decline yield and poor quality. But molecular mechanisms of cold tolerance wucai are still unclear. Results According to phenotypes physiological indexes, we screened out cold-tolerant genotype “W18” (named CT) cold-sensitive “Sw-1” CS) six genotypes. We performed transcriptomic analysis using seedling leaves after 24 h treatment. A total 3536 3887 differentially expressed genes (DEGs) were...