A5064516862- RNA modifications and cancer
- Cancer-related gene regulation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Epigenetics and DNA Methylation
- Synthesis of β-Lactam Compounds
- Synthesis and Catalytic Reactions
- Click Chemistry and Applications
- Synthesis and biological activity
- Microbial Natural Products and Biosynthesis
- Quinazolinone synthesis and applications
- Cancer-related molecular mechanisms research
- Text and Document Classification Technologies
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- HIV/AIDS drug development and treatment
- Natural Language Processing Techniques
- Cancer therapeutics and mechanisms
- Biochemical and Molecular Research
- CRISPR and Genetic Engineering
- Histone Deacetylase Inhibitors Research
- Topic Modeling
- Metal complexes synthesis and properties
- Bioactive Natural Diterpenoids Research
- Synthesis of Organic Compounds
Shanghai Jiao Tong University
2024-2025
Jilin University
2023-2025
Sichuan Agricultural University
2024
Chinese Academy of Sciences
2021-2024
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2024
Shanghai Institute of Organic Chemistry
2021-2024
Jilin Medical University
2024
Chongqing Normal University
2022
Fudan University
2016-2021
Shaanxi Research Design Institute of Petroleum and Chemical Industry
2021
A series of chiral β-lactam bridged analogues (3-substituted 1,4-diaryl-2-azetidinones) combretastatin A-4 (CA-4) were synthesized asymmetrically, and their antitumor activities evaluated in vitro vivo. The cocrystal structure tubulin complex with compound 9 was determined by X-ray crystallography, which showed that binds to the same site as colchicine similar binding mode, absolute configuration its C-4 first identified demonstrated be critically important for antiproliferative activities.
A series of novel five-membered sulfur-containing heterocyclic nucleoside derivatives were designed, synthesized, and evaluated for their anticancer activities in vitro vivo. The structure-activity relationship studies revealed that some them showed obvious antitumor several cancer cell lines. Among them, compound
5-Methylcytosine (m 5 C) is one of the major post-transcriptional modifications in mRNA and highly involved pathogenesis various diseases. However, capacity existing assays for accurately comprehensively transcriptome-wide m C mapping still needs improvement. Here, we develop a detection method named DRAM (deaminase reader protein assisted RNA methylation analysis), which deaminases (APOBEC1 TadA-8e) are fused with proteins (ALYREF YBX1) to identify sites through deamination events...
54 novel oxazolo [4,3-f]purine derivatives were designed, synthesized, and evaluated for antitumor activity, among which compound 20b exhibited potent activity against several cancer cell lines. Compound inhibited metastasis, arrested the cycle in G0/G1 phase, induced apoptosis HCT116 cells. Mechanistic studies revealed that increased ROS levels led to DNA damage, endoplasmic reticulum (ER) stress, mitochondrial dysfunction Limited proteolysis-small molecule mapping (LiP-SMap), drug affinity...
5-Methylcytosine (m 5 C) is one of the post-transcriptional modifications in mRNA and involved pathogenesis various diseases. However, capacity existing assays for accurately comprehensively transcriptome-wide m C mapping still needs improvement. Here, we develop a detection method named DRAM (deaminase reader protein assisted RNA methylation analysis), which deaminases (APOBEC1 TadA-8e) are fused with proteins (ALYREF YBX1) to identify sites through deamination events neighboring sites....
Disrupting microtubule dynamics has emerged as a promising strategy for cancer treatment. However, drug resistance remains challenge hindering the development of microtubule-targeting agents. In this work, novel class diaryl substituted fused heterocycles were designed, synthesized, and evaluated, which demonstrated effective dual katanin tubulin regulators with antitumor activity. Following three rounds stepwise optimization, compound 21b, featuring 3H-imidazo[4,5-b]pyridine core, displayed...
In order to discover novel hypoxia-inducible factor 1 (HIF-1) inhibitors for the cancer metastasis treatment, 68 new aryl carboxamide compounds were synthesized and evaluated their inhibitory effect by dual luciferase-reporter assay. Based on five rounds of investigation structure-activity relationships step step, compound 30m was discovered as most active inhibitor (IC50 = 0.32 μM) with no obvious cytotoxicity (CC50 > 50 μM). It effectively attenuated hypoxia-induced HIF-1α protein...
In the present work, 103 novel acyclic nucleosides were designed, synthesized, and evaluated for their anticancer activities in vitro vivo. The structure–activity relationship (SAR) studies revealed that most target compounds inhibited growth of colon cancer cells vitro, which 3-(6-chloro-9H-purin-9-yl)dodecan-1-ol (9b) exhibited potent effect against HCT-116 SW480 with IC50 values 0.89 1.15 μM, respectively. Furthermore, all (R)-configured nucleoside derivatives displayed more activity...
Summary Shoot apical meristem (SAM) is the origin of aerial structure formation in plant life cycle. However, mechanisms underlying maize SAM development are still obscure. Here, approximately 12 700 cells were captured from 5‐day‐old shoot apex using a high‐throughput single‐cell transcriptome sequencing. According to gene expression patterns, we partitioned into 8 cell types with 13 transcriptionally distinct clusters and traced developmental trajectory apex. Regulatory network analysis...
A phytochemical investigation of the MeOH extract leaves and twigs Amentotaxus argotaenia, a relict vulnerable coniferous species endemic to China, led isolation characterization 35 diterpenoids/norditerpenoids. Twenty these are new, including 11 ent-kaurane-type (amentotaxins C–M, 1–11, respectively), three icetexane-type [= 9(10→20)abeo-abietane-type N–P, 12–14, respectively)], four ent-labdane-type Q–T, 15–18, two isopimarane-type [amentotaxins U (19) V (20)] compounds. Their structures...
KBQA is a task that requires to answer questions by using semantic structured information in knowledge base. Previous work this area has been restricted due the lack of large parsing dataset and exponential growth searching space with increasing hops relation paths. In paper, we propose an efficient pipeline method equipped pretrained language model. By adopting beam search algorithm, will not be subgraph 3 hops. Besides, data generation strategy, which enables our model generalize well from...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Abstract 5-Methylcytosine (m 5 C) is one of the post-transcriptional modifications in mRNA and involved pathogenesis various diseases. However, capacity existing assays for accurately comprehensively transcriptome-wide m C mapping still needs improvement. Here, we develop a detection method named DRAM (deaminase reader protein assisted RNA methylation analysis), which deaminases (APOBEC1 TadA-8e) are fused with proteins (ALYREF YBX1) to identify sites through deamination events neighboring...