3D hydrogel microstructures that encapsulate cells have been used in broad applications microscale tissue engineering, personalized drug screening, and regenerative medicine. Recent technological advances microstructure assembly, such as bioprinting, magnetic microfluidics, acoustics, enabled the construction of designed structures with spatially organized vitro. However, a bottleneck exists still hampers application microtissue structures, due to lack techniques combined high‐throughput...

Cells are frequently studied because they basic structural, functional, and biological units of living organisms. Extracting features from cellular behaviors can facilitate decision making in medical diagnoses represents an important aspect the development biomedical engineering. Previous studies have just focused on either individual cell or clusters separately, which leads to a great lack information. Microwell technologies could address challenges vitro studies, 3D functional assays, by...

Chemoselective asymmetric [3 + 2] cycloaddition reactions of purines with aminocyclopropanes for the dearomatization have been successfully developed.

In the present work, 103 novel acyclic nucleosides were designed, synthesized, and evaluated for their anticancer activities in vitro vivo. The structure–activity relationship (SAR) studies revealed that most target compounds inhibited growth of colon cancer cells vitro, which 3-(6-chloro-9H-purin-9-yl)dodecan-1-ol (9b) exhibited potent effect against HCT-116 SW480 with IC50 values 0.89 1.15 μM, respectively. Furthermore, all (R)-configured nucleoside derivatives displayed more activity...

Consumer cameras in the megapixel range are ubiquitous, but improvement of them is hindered by poor performance and high cost traditional photodetectors. Graphene, a two-dimensional micro-/nano-material, recently has exhibited exceptional properties as sensing element photodetector over materials. However, it difficult to fabricate large-scale array graphene photodetectors replace array. To take full advantage unique characteristics photodetector, this study we integrated single-pixel camera...

A considerable number of studies have examined how intrinsic factors regulate breast cancer cell behaviours; however, physical microenvironmental cues may also modulate cellular morphology, proliferation, and migration mechanical properties.

A practical iron-catalyzed asymmetric 1,3-dipolar cycloaddition of N , ′-cyclic azomethine imines with α,β-unsaturated acyl imidazoles was developed to afford ′-bicyclic pyrazolidine in good yields and excellent stereoselectivities (up 98% ee).

Cell manipulation using optically induced dielectrophoresis (ODEP) in a microfluidic system has drawn much attention due to its simplicity and being damage-free at the cellular level. Additionally, improve efficiency accuracy, automatic methods have been applied ODEP system. However, current of rarely consider impact non-manipulated targets on cell manipulation, thereby reducing operating accuracy. Here, we propose new, our knowledge, method based path planning algorithm improved A-star....

New approach to detecting multidimensional and multicellular information from optogenetically engineered cells.

Quick tracking in nano-manipulation has been attracting increasing attention among scientific researchers and engineers because it can significantly enhance the effectiveness efficiency of nano-manipulation. The main reasons that hinder improvement accuracy are lack effective real-time unavoidable perturbations by uncertainties nonlinearities manipulation system. In this paper, we present a new strategy based on compressive sensing to realize quick trajectory, build kinematic model for...

Novel hybrid catalysts that resulted from the anchoring of pyrene-tagged Rh(<sc>i</sc>) complexes onto graphene materials <italic>via</italic> π–π stacking interactions show excellent catalytic activity towards hydrogenation dehydroamino acid.

An endoscopy is a tool that used to examine the interior of hollow organ or cavity body by inserting directly into organ. However, intestinal not friendly patients due discomfort, and it can easily cause damage even perforation use rigid materials endoscopy. Here, we provide an earthworm-based soft robot equipped with gripper for application on exams surgery. The composed frontal radial actuator, central axial rear actuator gripper. first three actuators drive move freely in some specific...

Viscoelasticity is a crucial property of cells, which plays an important role in label-free cell characterization. This paper reports model-fitting-free viscoelasticity calculation method, correcting the effects frequency, surface adhesion and liquid resistance on AFM force-distance (FD) curves. As demonstrated by quantifying viscosity elastic modulus PC-3 this method shows high self-consistency little dependence experimental parameters such as loading mode (Force-volume vs. PeakForce...

Colorectal cancer as a major disease that poses serious threat to human health continues rise in incidence. And the timely colon examinations are crucial for prevention, diagnosis, and treatment of this disease. Clinically, gastroscopy is used universal means examination, prevention diagnosis disease, but detection method not patient-friendly can easily cause damage intestinal mucosa. Soft robots an emerging technology offer promising approach examining, diagnosing, treating diseases due...

Saccharomyces cerevisiae(S. cerevisiae) has been classically used as a treatment for diarrhea and diarrhea-related diseases. However, cases of the fungal infections caused by S. cerevisiae have increasing in last two decades among immunocompromised patients, while long time was spent on isolation clinically so it difficult to achieve timely diagnosis Here, novel approach selection is proposed designing microfluidic chip with an optically induced dielectrophoresis (ODEP) system. isolated from...

Scanning Ion Conductance Microscopy (SICM) is one kind of Probe Microscopies (SPMs), and it widely used in imaging soft samples for many distinctive advantages. However, the scanning speed SICM much slower than other SPMs. Compressive sensing (CS) could improve tremendously by breaking through Shannon sampling theorem, but still requires too time image reconstruction. Block compressive can be applied to further reduce reconstruction sparse signals, has another unique application that achieve...

Microrobots have emerged as a promising precision therapy approach that has been widely used in minimally invasive treatments, targeted drug delivery, and wound cleansing, they also offer potential new method for actively modulating gut microbiota. Here, double-faced microrobot was designed to carry bacteria via covalently immobilizing the antibodies, corresponding integrated optical magnetic dual-driving control system developed precise of microrobot. The utilizes microsphere its core, with...

Abstract Biosyncretic systems integrating biological components with electromechanical devices have recently become a promising technology, in which are used as actuators or sensing elements higher‐level performance than artificial systems. Here, biosyncretic imaging system using an optogenetically engineered living cell photodetector is shown. The photoresponsive properties of the cell, such spectrum and response range, dynamic characteristics, measured indicate that functions excellent...

An image biosensor is built by an optogenetically engineered cell and used to acquire high-resolution images for the development of new generation visual prostheses.

Compressive radar imaging has attracted considerable attention because it substantially reduces time through directly compressive sampling. However, a problem that must be addressed for systems is the high computational complexity of reconstruction sparse signals. In this paper, novel algorithm, called two-dimensional (2D) normalized iterative hard thresholding (NIHT) or 2D-NIHT proposed to reconstruct images in matrix domain. The performance algorithm was validated by an experiment on...