A5057500089- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Surface Chemistry and Catalysis
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Axial and Atropisomeric Chirality Synthesis
- Crystallography and molecular interactions
- Metal-Organic Frameworks: Synthesis and Applications
- Carbon dioxide utilization in catalysis
- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Organometallic Complex Synthesis and Catalysis
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Organophosphorus compounds synthesis
- Molecular spectroscopy and chirality
- Catalysis for Biomass Conversion
- Fluorine in Organic Chemistry
- Polyoxometalates: Synthesis and Applications
- Nanomaterials for catalytic reactions
- Advanced Synthetic Organic Chemistry
- Catalysts for Methane Reforming
Shanghai Institute of Organic Chemistry
2016-2025
Shanghai Jiao Tong University
2020-2025
University of Science and Technology of China
2008-2025
University of Chinese Academy of Sciences
2016-2025
Chinese Academy of Sciences
2015-2024
ShanghaiTech University
2019-2024
Leibniz Institute for Catalysis
2022
East China University of Science and Technology
2020
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2015-2020
Nankai University
2003-2019
Abstract The organometallic approach is one of the most active topics in catalysis. application NH functionality catalysis has become an important and attractive concept catalyst design. moieties modifiers catalysts have been shown to various beneficial functions by molecular recognition through hydrogen bonding give catalyst–substrate, ligand–ligand, ligand–catalyst, catalyst–catalyst interactions. This Review summarizes recent progress development based on cooperative focusing moiety.
Two birds with one stone: the simultaneous production of two important bulk chemicals, methanol and ethylene glycol, from CO(2) oxide has been achieved under mild conditions by highly efficient homogeneous catalytic hydrogenation carbonate in presence a (PNP)Ru(II) catalyst.
A spiroketal bisphosphine (SKP) derived chiral digold complex is identified as a powerful catalyst for the highly diastereo- and enantioselective synthesis of spirocyclopropyloxindoles from diazooxindoles broad range alkenes, including both cis trans 1,2-disubstituted alkenes.
Abstract A highly efficient catalyst system based on ruthenium‐pincer‐type complexes has been discovered for N‐formylation of various amines with CO 2 and H , thus affording the corresponding formamides excellent productivity (turnover numbers up to 1 940 000 in a single batch) selectivity. Using simple recycling protocol, was reused 12 runs N ‐dimethylformamide production without significant loss activity, demonstrating potential practical utilization this cost‐effective process. one‐pot...
From spiro to spiro: An iridium(I) complex with a spiral P,N ligand (SpinPhox) is highly efficient in the catalytic asymmetric hydrogenation of α,α′-bis(2-hydroxyarylidene) ketones afford corresponding aromatic spiroketals high yields excellent diastereo- and enantioselectivities (see scheme). The plays dual role reaction, acting as catalyst for both CC bonds subsequent spiroketalization bisphenolic ketones.
A series of MnI complexes containing lutidine-based chiral pincer ligands with modular and tunable structures has been developed. The complex shows unprecedentedly high activities (up to 9800 TON; TON=turnover number), broad substrate scope (81 examples), good functional-group tolerance, excellent enantioselectivities (85-98 % ee) in the hydrogenation various ketones. These aspects are rare earth-abundant metal catalyzed hydrogenations. utility protocol have demonstrated asymmetric synthesis...
Combinatorial coordination chemistry strategy combined with high-throughput screening techniques has been successfully applied to engineering practical enantioselective catalysts for asymmetric hetero-Diels−Alder reaction. The reaction of Danishefsky's diene a variety aldehydes can be carried out 0.1−0.005 mol % H4-BINOL/Ti/H4-BINOL or H4-BINOL/Ti/H8-BINOL at room temperature under solvent- and MS-free conditions afford dihydropyrone derivatives up quantitative yield 99.8% ee.
From imines to amines through catalysis by Ir(I) complexes of a new type P,N ligand (see scheme): This reaction affords the corresponding optically active with up 98 % ee and has also been used perfect stereoselectivity in asymmetric synthesis sertraline (1), an important antidepressant chiral drug.
Abstract The intramolecular dinuclear zinc complexes generated in situ from the reaction of multidentate semi‐azacrown ether ligands with Et 2 Zn, followed by treatment an alcohol additive, were found to promote copolymerization CO and cyclohexene oxide (CHO) completely alternating polycarbonate selectivity high efficiency. With this type novel initiator, could be accomplished under mild conditions at 1 atm pressure , which represents a significant advantage over most catalytic systems...
The most effective catalyst system for the enantioselective alkylation of an aldehyde on basis "asymmetric activation" can be found by super high throughput screening chiral ligands (L*) and activators (A*) diethylzinc complex. product, optically active alcohol, could obtained with 99% ee in up to 100% yield (see reaction scheme). R=benzylidene.
A catalytic amount of a chiral Brønsted acid with aqueous H2O2 as the oxidant is sufficient for enantioselective Baeyer–Villiger oxidation 3-substituted cyclobutanones to give corresponding γ-lactones in excellent yields and up 93 % ee. The method employs benign instead stoichiometric amounts dangerous peracid.
Showing a backbone: The spiroketal backbone of the bis(phosphine) ligand 1 led to good regio- and enantioselectivity in palladium-catalyzed asymmetric allylic amination racemic Morita–Baylis–Hillman adducts with aromatic amines. methodology provides facile efficient synthesis precursors for optically active β-lactam derivatives, including cholesterol drug Ezetimibe.
The intramolecularly dinuclear magnesium complexes generated in situ from the reaction of multidentate semi-azacrown ether ligands with n-Bu2Mg followed by treatment alcohol additive were found to be efficient catalysts for copolymerization CO2 and cyclohexene oxide (CHO), affording completely alternating poly(cyclohexene carbonate) (PCHC) under extremely mild conditions (1 atm pressure CO2, temperatures ranging 20 60 °C). Ligand substituent effects observed dramatically influence both...
Asymmetric catalysis in flow has been attracting much attention very recently because of the potential advantages over its batchwise counterpart, such as high-throughput screening and synthesis, easy automation with integration on-demand reaction analysis, little or no workup, long-term use catalysts case heterogeneous catalysis. Homogeneous asymmetric performed a microreactor demonstrated successful examples fast catalyst screening, integrated inline/onlineanalysis, microflow...
Abstract A rhodium‐catalyzed one‐pot hydroformylation of olefins with CO 2 , hydrosilane, and H has been developed that affords the aldehydes in good chemoselectivities at low catalyst loading. Mechanistic studies indicate transformation is likely to proceed through a tandem sequence poly(methylhydrosiloxane) (PMHS) mediated reduction conventional CO/H . The hydrosilylane‐mediated preference was found be crucial for selective formation under reaction conditions.
Copper–silica nanocomposite catalysts have been found to be highly efficient and stable in the heterogeneous hydrogenation of CO 2 -derived cyclic carbonates give methanol diols under relatively mild conditions.
1,1′-Spirobiindane has been one type of privileged skeleton for chiral ligand design, and 1,1′-spirobiindane-based ligands have demonstrated outstanding performance in various asymmetric catalysis. However, the access to enantiopure spirobiindane is quite tedious, which obstructs its practical application. In present article, a facile enantioselective synthesis cyclohexyl-fused spirobiindanes accomplished, high yields excellent stereoselectivities (up >99% ee), via sequence Ir-catalyzed...
An enantioselective alkoxycarbonylation-amination cascade process of terminal allenes with CO, methanol, and arylamines has been developed. It proceeds under mild conditions (room temperature, ambient pressure CO) via oxidative Pd(II) catalysis using an aromatic spiroketal-based diphosphine (SKP) as a chiral ligand Cu(II) salt oxidant affords wide range α-methylene-β-arylamino acid esters (36 examples) in good yields excellent enantioselectivity (up to 96% ee) high regioselectivity...
Abstract A Mn‐catalyzed diastereo‐ and enantioselective hydrogenation of α‐substituted β‐ketoamides has been realized for the first time under dynamic kinetic resolution conditions. anti ‐α‐Substituted β‐hydroxy amides, which are useful building blocks synthesis bioactive molecules chiral drugs, were prepared in high yields with excellent selectivity (up to >99 % dr ee ) unprecedentedly activity (TON up 10000). The origin stereoselectivity was clarified by DFT calculations.
ConspectusWhile spectacular successes have been achieved in homogeneous catalysis with the use of achiral diphosphine ligands featuring a wide natural bite angle, such as XantPhos, chiral diphosphines that can induce large P–M–P angle their transition metal complexes are conspicuously less explored asymmetric catalysis, probably due to challenges identification and efficient construction suitable backbone. In past decade, highly synthesis aromatic spiroketals corresponding (SKPs) has...
A new type of chiral super Brønsted C–H acids, BINOL-derived phosphoryl bis((trifluoromethyl)sulfonyl) methanes (BPTMs), were developed. As compared to widely utilized phosphoric acids (BPAs) and N-triflyl phosphoramides (NTPAs), BPTMs displayed much higher acidity, resulting in dramatically improved activity excellent enantioselectivity as demonstrated catalytic asymmetric Mukaiyama–Mannich reaction, allylic amination, three-component coupling allyltrimethylsilane with 9-fluorenylmethyl...