A5100451715- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Catalytic Reactions
- Axial and Atropisomeric Chirality Synthesis
- Sulfur-Based Synthesis Techniques
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Reactions
- Chemical Synthesis and Analysis
- Oxidative Organic Chemistry Reactions
- Fluorine in Organic Chemistry
- Synthesis and Biological Evaluation
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Molecular spectroscopy and chirality
- Synthesis of Indole Derivatives
- Mass Spectrometry Techniques and Applications
- Carbohydrate Chemistry and Synthesis
- Advanced Proteomics Techniques and Applications
- Catalytic Alkyne Reactions
- Synthesis and Reactions of Organic Compounds
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Multicomponent Synthesis of Heterocycles
- Click Chemistry and Applications
- Advanced Image and Video Retrieval Techniques
Chengdu Women's and Children's Central Hospital
2025
Chengdu Medical College
2025
Yichun University
2025
Zhejiang University of Technology
2011-2024
Qingdao Agricultural University
2024
Jiangxi Normal University
2020-2023
Shenzhen University
2023
Shanghai Institute of Organic Chemistry
2013-2023
Chinese Academy of Sciences
2012-2023
Pharmaceutical Biotechnology (Czechia)
2020-2023
Abstract A novel reagent, which introduces two sulfur atoms in one step, was designed and used for the construction of diverse disulfanes by copper‐catalyzed oxidative cross‐coupling under mild reaction conditions. By applying this stable readily prepared late‐stage modification pharmaceuticals natural products can be achieved straightforward. The scaled‐up experiments further indicated practicality protocol. pH value system plays a key role achieving highly selective cleavage C−S bond...
Organofluorine compounds are of high value. NHC-catalyzed fluorination and fluoroalkylation have served as powerful versatile vehicles for accessing the related organofluorines. This review focuses on recent developments in this area.
A novel Pd-catalyzed double C–S bond formation coupling reaction has been developed. This protocol, in which Na2S2O3 was used as sulfurating reagent metal-catalyzed reactions, provides an efficient method for the synthesis of substituted 1,4-benzothiazine derivates, are structural elements numerous bioactivity molecules rendering this protocol attractive to both synthetic and medicinal chemistry.
From life science to material science, pharmaceutical industry, and food chemistry, polysulfides are vital structural scaffolds. However, there limited synthetic methods for unsymmetrical polysulfides. Conventional strategies entail two pre-sulfurated cross-coupling substrates, R-S, with higher chances of side reactions due the characteristic sulfur. Herein, a library broad-spectrum polysulfurating reagents, R-S-S-OMe, designed scalably synthesized, which R-S-S source can be directly...
A sulfur redox process has been developed between sulfinate and thiosulfate, which efficiently affords diverse unsymmetrical disulfides provides a new method to modify pharmaceuticals natural products without requiring an extra oxidant or reductant. Gram-scale investigation further demonstrates the practicality application potential of this process. Isolated key intermediates series control experiments afford unusual process, reveals mechanism comproportionation transition-metal-free
The latest achievements in the catalytic asymmetric synthesis of both monofluoro- and <italic>gem</italic>-difluoroalkenes are discussed.
In this review article, we summarized recent advances in the transition metal-catalyzed heteroannulative difunctionalization of alkenes via direct C–H activation to access heterocyclic frameworks.
A variety of enantioenriched spirofuro[2,3- b ]azepine-5,3’-indoline derivatives were synthesized via Au(I)/chiral NHC relay catalyzed cycloisomerization/asymmetric [4+3] annulation.
Abstract The catalytic asymmetric dearomatization (CADA) reaction has proved to be a powerful protocol for rapid assembly of valuable three-dimensional cyclic compounds from readily available planar aromatics. In contrast the well-studied indoles and naphthols, phenols have been considered challenging substrates intermolecular CADA reactions due combination strong aromaticity potential regioselectivity issue over multiple nucleophilic sites (O, C2 as well C4). Reported herein are chiral...
Flow chemistry provides a neo-orientation for the research and development of chemical technology, in which heterogeneous continuous catalysis based on packed beds can realize rapid separation recycling. However, options catalysts are still limited. In this work, we gradually grow covalent organic frameworks (COFs, TpBpy) surface silica gel (SiO2)-supported substrate to obtain stable copper(I)-chelated high-loading catalyst (SiO2@CuI-TpBpy). SiO2@CuI-TpBpy shows high catalytic activity...
This communication describes a chiral base-catalyzed asymmetric [1,3]-proton shift of trifluoromethyl ketimines, giving wide variety aldimines containing various functional groups with up to 94% ee.
A chiral ytterbium(III)-N,N'-dioxide catalyst system has been developed for the catalytic direct asymmetric vinylogous Michael addition of 3-alkylidene oxindoles to chalcones, delivering γ-substituted alkylideneoxindoles in high yields, enantioselectivities and good Z/E selectivities under mild reaction conditions.
Abstract Asymmetric multi‐catalysis, designed to mimic catalytic processes in nature, is a powerful instrument fulfil fascinating transformations. As result, this area of research has attracted considerable interests within chemistry communities. Although there are numerous reviews involving describing asymmetric organomulticatalysis remain rare. Taking into consideration that organocatalysts possess the superiorities effortless availability, inexpensiveness, hypotoxicity, facile handling...
Regional and stereoselective construction of spirooxindole-fused spiropyrazolones containing contiguous three stereogenic centres <italic>via</italic> [3 + 2] annulation catalyzed by ferrocene derived bifunctional phosphine.
We have established a practical and concise method for the straightforward access of universal deuterated methylthiolating reagent through one-pot gram-scale operation under mild conditions. This odourless electrophilic SCD3 was widely applied to react with numerous representative nucleophiles approached various valuable analogues excellent levels deuterium content (>99% D). The divergent further transformations were smoothly carried out obtain significant derivatives different oxidative...
Abstract Herein, the first diversity‐oriented catalytic asymmetric dearomatization of indoles with o ‐quinone diimides ( ‐QDIs) is reported. The (CADA) one research focuses in terms structural and biological importance dearomatized indole derivatives. Although great achievements have been made target‐oriented CADA reactions, reactions are regarded as more challenging remain elusive due to lack synthons featuring multiple reaction sites difficulty precise control chemo‐, regio‐,...
Worth its salt: An orgnaocatalytic asymmetric intramolecular aza-Michael reaction and one-pot bromination of activated α,β-unsaturated ketones have been realized using a chiral bisguanidium salt (see scheme). Optically enriched 2-aryl- 2-alkyl-substituted dihydroquinones brominated could be obtained (up to 99 % yield ee for the reaction; up 95 yield, 96:4 d.r., reaction). Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but...
Reported herein is an unprecedented copper-catalyzed site-selective δ-C(sp3)–H bonds activation of aliphatic sulfonamides for constructing the synthetically useful seven-membered N-heterocycles. A key to success use in-situ-formed amide radicals, activate inert C(sp3)–H bond, and inexpensive TMSNCO, as a coupling reagent under mild conditions. To best our knowledge, this represents first alkylamine derivatives five-membered synthon prepare
We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) malonates. These gram-scale approaches occur with turnovers of up 1560 are smoothly conducted the usage low catalyst loading, new ligand, green solvent. A variety functional groups tolerated, application occurs access nonsteroidal anti-inflammatory drugs (NSAIDs) on gram scale.
We have developed a methodology for the greatly efficient construction of significant 2,3-dihydrobenzofuran scaffolds bearing quaternary carbon center at C2 position by means [4 + 1] annulation reactions between p-quinone methides and α-aryl diazoacetates as C1 synthons through organocatalysis readily accessible TfOH catalyst under mild transition metal-free conditions. This protocol furnishes an operationally simple swift process free assembly diverse highly functionalized...
A new type of organocatalyzed 1,3-thiosulfonylation has been developed to straightforwardly access highly functionalized vinyl sulfones, which features mild conditions, atom- and step-economy, practicability, conciseness, environmental friendliness. Moreover, these valuable products can be transformed sulfides via a base-promoted isomerization. The versatile route efficiently rapidly introduce SCD3 groups with excellent levels deuterium content (>99% D) by utilizing our newly reagents....