A5111687584- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Plant chemical constituents analysis
- Advanced biosensing and bioanalysis techniques
- Pharmacological Effects of Natural Compounds
- Advanced Proteomics Techniques and Applications
- Parasitic Infections and Diagnostics
- Helminth infection and control
- Atmospheric chemistry and aerosols
- Chromatography in Natural Products
- Molecular Biology Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Coccidia and coccidiosis research
- Synthetic Organic Chemistry Methods
- Seed and Plant Biochemistry
- Per- and polyfluoroalkyl substances research
- Microbial Natural Products and Biosynthesis
- Protein Hydrolysis and Bioactive Peptides
- Helicobacter pylori-related gastroenterology studies
- Biological Activity of Diterpenoids and Biflavonoids
- Enzyme Production and Characterization
- Gut microbiota and health
- Food composition and properties
- Enzyme Catalysis and Immobilization
Liaoning University of Traditional Chinese Medicine
2025
Nanjing Agricultural University
2025
Shanxi Agricultural University
2021
Shanxi Fenyang Hospital
2021
Shanxi Medical University
2021
Central China Normal University
2013-2016
Peking University
2008-2009
Whole grain flour is considered a part of healthy diet, especially when produced with pigmented wheat (Triticum aestivum). However, the specific metabolic pathways and mechanisms by which these metabolites affect end-use quality varieties still need to be better understood. This study examined relationship between metabolite concentrations three varieties: common (CW, JM20), black (BW, HJ1), green (GW, HZ148). The study's findings revealed significant differences in accumulation substances...
Background: Zhishi decoction (ZSD) is one of the most common herb decoctions in traditional Chinese medicine (TCM), and it used for treatment FC. However, its main therapeutic mechanism not yet clear. This study aims to explore possible pharmacodynamic material basis potential molecular from network pharmacology docking verify them through animal experiments. Methods: Firstly, effective ingredients, targets, key targets ZSD FC were screened pharmacology. Go KEGG analyses performed targets....
Drug-target interaction prediction (DTI) is essential in various applications including drug discovery and clinical application. There are two perspectives of input data widely used DTI prediction: Intrinsic represents how drugs or targets constructed, extrinsic related to other biological entities. However, any the can be scarce for some targets, especially those unpopular newly discovered. Furthermore, ground-truth labels specific types also scarce. Therefore, we propose first method...
In this study, four types of compounds including coumarins, chromones, furoylmethyl amino acid derivative and benzofuran glycoside were isolated from the roots Saposhnikovia divaricata. The electrospray ionization (ESI) mass spectral fragmentation pathways these proposed. particular, ESI-MS(n) behavior linear dihydrofurocoumarins, dihydrofuro- dihydropyranochromones deduced in detail. For was triggered by initial loss C-4' substituting group. Then, characteristic ions observed followed...
From the roots of Saposhnikovia divaricata, three new compounds, divaricataesters A (1), B (2), and C (3) were isolated, along with known cimifugin (4), (3S)-2,2-dimethyl-3,5-dihydroxy-8-hydroxymethyl-3,4-dihydro-2H,6H-benzo[1,2-b:5,4-b′]dipyran-6-one (5) 5-hydroxymethyl-furfurol (6). Their structures established by spectral analysis comparison reported data in literatures.
Abstract Polyacrylamide gel electrophoresis (PAGE) coupled with mass spectrometry has been well established for separating, identifying and quantifying protein mixtures from cell lines, tissues or other biological samples. The copolymerization process of acrylamide bis-acrylamide is the key to mastering this powerful technique. In general, a vinyl addition reaction initiated by free radical-generating reagents such as ammonium persulfate (APS) tetramethylethylenediamine (TEMED) under basic...
Cryptotanshinone (1) is one of the major bioactive constituents in Salvia miltiorrhiza Bunge. Preparative-scale biotransformation cryptotanshinone by Cunninghamella elegans (AS 3.2082) produced three new products, which were identified as (3R,15R)-3-hydroxycryptotanshinone (2), (3S,15R)-3-hydroxycryptotanshinone (3), and (4S,15R)-18-hydroxycryptotanshinone (4), respectively. The structural elucidation was based primarily on 1D 2D NMR HR-ESI-MS analyses. absolute configuration these products...
Abstract Background: Buzhongyiqi decoction (B), Sijunzi (S), and Shenlingbaizhu (SH) have been extensively clinically used for the treatment of health status diseases caused by spleen-qi deficiency many years microbial fermentation has widely applied in Traditional Chinese Medicine (TCM) thousands China. This study was aimed to investigate mitigative effect TCM fermented (FTCM) with Lactobacillus plantarum (LP) antibiotic-associated diarrhea (AAD), identify compounds S Fermented (FS)....