A5101915717- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Plant Gene Expression Analysis
- Plant Stress Responses and Tolerance
- Plant Micronutrient Interactions and Effects
- Ion Channels and Receptors
- Photosynthetic Processes and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- NF-κB Signaling Pathways
- Metabolomics and Mass Spectrometry Studies
- Connective tissue disorders research
- Aluminum toxicity and tolerance in plants and animals
- Agricultural pest management studies
- RNA Research and Splicing
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Trace Elements in Health
- Plant Genetic and Mutation Studies
- Magnesium in Health and Disease
- Genetic factors in colorectal cancer
- Endoplasmic Reticulum Stress and Disease
Yangtze University
2017-2024
University of South China
2024
Jingzhou Central Hospital
2015-2024
Anhui Agricultural University
2022-2023
Shenzhen University
2022
Yangzhou University
2020
Jiangsu Province Hospital
2020
Northern Jiangsu People's Hospital
2020
Huaian First People’s Hospital
2020
Abstract Background Wucai suffers from low temperature during the growth period, resulting in a decline yield and poor quality. But molecular mechanisms of cold tolerance wucai are still unclear. Results According to phenotypes physiological indexes, we screened out cold-tolerant genotype “W18” (named CT) cold-sensitive “Sw-1” CS) six genotypes. We performed transcriptomic analysis using seedling leaves after 24 h treatment. A total 3536 3887 differentially expressed genes (DEGs) were...
Abstract Brassica parachinensis is a popular leafy vegetable. It able to accumulate high concentrations of cadmium (Cd), but the molecular mechanism Cd accumulation unknown. This study investigated function and regulatory Cd-responsive metal ion transporter gene BrpHMA2. BrpHMA2 was induced by stress specifically expressed in vascular tissues, protein localized plasma membrane. Heterologous expression enhanced sensitivity transgenic Arabidopsis yeast. After stress, transcription factors...
Wucai (Brassica campestris L.) is a leafy vegetable that originated in China, its soluble sugars accumulate significantly to improve taste quality during maturation, and it widely accepted by consumers. In this study, we investigated the sugar content at different developmental stages. Two periods including 34 days after planting (DAP) 46 DAP, which represent period prior accumulation, respectively, were selected for metabolomic transcriptomic profiling. Differentially accumulated...
The present study investigated the anti‑tumor activity of N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a potent and specific inhibitor transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. TRPM8 expression normal PNT1A cells was detected by reverse transcription polymerase chain reaction western blot analysis. effect BCTC on analyzed flow cytometry analysis, MTT, scratch motility...
NF-κB signaling is very important in cancers. However, the role of BRCC3-associated activation bladder cancer remains to be characterized. Western blotting and IHC tissue microarray were used confirm abnormal expression BRCC3 cancer. Growth curve, colony formation, soft agar assay Xenograft model performed identify over-expression or knock-out Further, RNA-Seq luciferase reporter assays down-stream pathway. Finally, co-immunoprecipitation fluorescence confocal verify precise target BRCC3....
Prostate cancer (PCa) is one of the most prevalent types among men worldwide. The incidence PCa increasing in China. Therefore, there an urgent need to identify novel diagnostic and prognostic markers for improve treatment disease.The Cancer Genome Atlas (TCGA) GEO database were used analyze expression miR-192, relationship between miR-192 clinical features patients with PCa. Cell cycle cell proliferation assay detect functional roles Bioinformatic analysis miR-192-5p was performed using...
BACKGROUND:The aim of this study was to detect the expression epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) and estimate its diagnostic value in prostate cancer (PCa). MATERIAL AND METHODS:EFEMP1 serum urine patients with PCa, benign controls healthy at mRNA level were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) enzyme-linked immunosorbent assay (ELISA) analysis, respectively. The chi-square test used analyze...
The relationship between microRNAs, such as miR-654-5p and miR-376b-3p, the prognosis of colon cancer has not been studied until now.To evaluate expression levels miR-376b-3p their clinical significance in cancer.RT-qPCR was performed to 34 pairs adjacent noncancerous tissues. Subsequently, association with factors or survival patients suffering from determined by using Cancer Genome Atlas.miR-654-5p upregulated downregulated tissues compared (P < 0.001). Increased decreased were...
Several studies have shown that transient receptor potential cation channel subfamily M member 8 (TRPM8), which has been regarded as a novel prostate-specific marker, serves key role in processes such the proliferation, viability and cell migration of prostate cancer cells. Efforts made to uncover targeting TRPM8 management cancer; it verified TRPM8-targeted blockade, either by RNA interference-mediated depletion or specific inhibitors, could reduce rate proliferation proliferative fraction,...
Urologic cancers, comprising prostate carcinoma (PCa), renal cell (RCC), and bladder (BCa), were the commonly occurred amid males. Long noncoding RNAs (lncRNAs) with length of more than 200 nt functioned importantly in physiological pathological advancement. Nevertheless, further investigation regarding lncRNA expression feature function urologic cancers should be essential. This study is aimed at uncovering roles differently expressed lncRNAs cancers. The data gene levels was downloaded...
The aim of the present study was to explore expression levels tumor suppressor candidate 3 (TUSC3) in human clear cell renal carcinoma (ccRCC) and its clinical value. Immunohistochemical staining, western blotting reverse transcription-quantitative polymerase chain reaction were used detect TUSC3 paracancerous normal tissues ccRCC tissues. derived from pathological specimens 54 patients with ccRCC. Additionally, associations among histological grade clinicopathological staging investigated....
Renal cell carcinoma (RCC) stands as a prevalent malignancy within urological pathology, exhibiting noteworthy escalation in its incidence. Despite being mitochondrial enzyme, the precise role of Acetyl-CoA Acetyltransferase 1 (ACAT1) RCC remains elusive. In this investigation, we employed bioinformatics methodologies to assess expression patterns and prognostic significance across various subtypes, encompassing clear renal (ccRCC), papillary carcinoma, chromophobe carcinoma. Our findings...