A5056685277- Mycotoxins in Agriculture and Food
- Genomics, phytochemicals, and oxidative stress
- Gut microbiota and health
- Cervical Cancer and HPV Research
- Tuberculosis Research and Epidemiology
- Milk Quality and Mastitis in Dairy Cows
- Reproductive tract infections research
- Plant Toxicity and Pharmacological Properties
- Transplantation: Methods and Outcomes
- Sirtuins and Resveratrol in Medicine
- Rabies epidemiology and control
- Cardiac Ischemia and Reperfusion
- Microbial infections and disease research
- Agriculture, Soil, Plant Science
- Preterm Birth and Chorioamnionitis
- Plant Disease Resistance and Genetics
- Virology and Viral Diseases
- Ferroptosis and cancer prognosis
- Ecology and Conservation Studies
- Neonatal Respiratory Health Research
- Machine Learning in Bioinformatics
- Advanced Proteomics Techniques and Applications
- Antioxidant Activity and Oxidative Stress
- Animal Nutrition and Physiology
- Probiotics and Fermented Foods
Guizhou Normal University
2025
Chinese PLA General Hospital
2018-2024
Jilin University
2018-2023
Hebei Academy of Agriculture and Forestry Sciences
2023
National Chung Hsing University
2023
Fu Jen Catholic University
2014-2015
Ferroptosis is a form of oxidative cell death and has become chemotherapeutic target for cancer treatment. Curcumin (CUR), well-known inhibitor, significantly inhibits the viability breast cells. Through transcriptomic analysis flow cytometry experiments, it was found that after 48 hours treatment cells at its half maximal inhibitory concentration (IC50), curcumin suppressed via induction ferroptotic death. Use ferroptosis inhibitor ferrostatin-1 iron chelator deferoxamine rescued induced by...
Abstract Background Primary cervical cancer screening and treating precancerous lesions are effective ways to prevent cancer. However, the coverage rates of human papillomavirus (HPV) vaccines routine low in most developing countries even some developed countries. This study aimed explore benefit an artificial intelligence-assisted cytology (AI) system a program for high-risk population China. Methods A total 1231 liquid-based (LBC) slides from women who underwent colposcopy at Chinese PLA...
Lipopolysaccharide (LPS) is an endotoxin, which may cause immune response and inflammation of bovine mammary glands. Mastitis impairs animal health results in economic loss. Curcumin (CUR) a naturally occurring diketone compound, has attracted widespread attention as potential anti-inflammatory antioxidant. The purpose this study to investigate whether CUR can reduce the damage epithelial cells (MAC-T) induced by LPS its underlying molecular mechanism. MAC-T cell line was treated with...
Aflatoxin B1 (AFB1), a typical fungal toxin found in feed, is highly carcinogenic. Oxidative stress one of the main ways it exerts its toxicity; therefore, finding suitable antioxidant key to reducing toxicity. Astaxanthin (AST) carotenoid with strong properties. The aim present research was determine whether AST eases AFB1-induced impairment IPEC-J2 cells, and specific mechanism action. AFB1 were applied cells different concentrations for 24 h. (80 µM) significantly prevented reduction cell...
Both zearalenone (ZEA) and lipopolysaccharide (LPS) can induce oxidative stress, even apoptosis in bovine mammary epithelial cells (MAC-T), but not much attention has been given to the synergistic effect of ZEA LPS. In this study, we treated MAC-T with different concentrations LPS (1, 10, 50, 100 μg/mL) (5, 15, 30 μM) cell damage. Previous results show that viability decreases increasing concentration. Meanwhile, 1 µg/mL were selected for combined treatment subsequent studies. It was found...
Zanthoxylum planispinum var. Dingtanensis (hereafter Z. planispinum) has excellent characteristics, including Ca and drought tolerance. It can flourish in stony soils, it is used as a pioneer plant karst rocky desertification control. However, soil degradation, coupled with the removal of nutrients absorbed from by planispinum’s fruit harvesting, exacerbates nutrient deficiency. The effects fertilization on utilization microbial limiting factors remain unclear. Here, we established long-term...
Deoxynivalenol (DON) is a toxic secondary metabolite produced by Fusarium graminearum. It one of the most common feed contaminants that poses serious threat to health and performance dairy cows. This study investigated in vitro cytotoxicity DON on bovine mammary epithelial cells (MAC-T). at different concentrations (0.25, 0.3, 0.5, 0.8, 1 or 2 μg/ml) inhibited growth MAC-T after 24 hr exposure (p < .001). 0.25 μg/ml increased lactate dehydrogenase (LDH) leakage .05); decreased glutathione...
Zearalenone (ZEA) is a common mycotoxin produced by fungi within the genus Fusarium. However, few studies have examined direct effects of toxin on mammary glands. In present study, ZEA treatment bovine epithelial cells (MAC-T) from dairy cows were investigated. The treated with different concentrations to evaluate effect cell viability, intracellular reactive oxygen species (ROS) concentrations, mitochondrial membrane potential, endoplasmic reticulum (ER) stress, and expression...
Zearalenone (ZEA) is a mycotoxin that mainly produced by Fusarium fungi in food and feed. It causes many adverse effects on mammals, but there little research the of ZEA intestinal mucosal immunity flora animals or humans. In this study, we aimed to explore short-term exposure microecological balance intestine. We found morphological structure mucosa mice was severely destroyed after administered gavage for one week, mRNA expression levels β-defensin, Mucin-1, Mucin-2, interleukin-1beta...
Grape pomace (GP) is an abundant by-product from wine production and rich in phenolic compounds, unsaturated fatty acids, dietary fibre beneficial bacteria. In this study, weaned piglets were fed a basic diet supplemented with 5% GP for 4 weeks. Compared those the control (CON) group, it was found that proportion of Lactobacillus delbrueckii, Olsenella umbonata Selenomonas bovis caecum villus height height/crypt depth ratio (VCR) jejunum both significantly increased group (p < 0.05)....
Zearalenone (ZEA) is a mycotoxin of the Fusarium genus that can cause endoplasmic reticulum (ER) stress and Apoptosis in bovine mammary epithelial cells (MAC-T). Polydatin (PD), glycoside purified from Polygonum cuspidatum, has antioxidant properties. This study aimed to explore whether PD alleviate ZEA-induced damage on We found incasing concentration ZEA (0, 7.5, 15, 30, 60, 90, 120, 240 μM) gradually decreased cell viability. treatment alone at 5, 10, 20 μM did not affect Follow-up...
Deoxynivalenol (DON), a mycotoxin produced by Fusarium graminearum, is one of the most prevalent contaminants in livestock feed and causes very large losses to animal husbandry every year. Taraxasterol, isolated from Taraxacum officinale, has anti-inflammatory, antioxidative stress, antitumor effects. In present study, bovine mammary epithelial cells (MAC-T) were used as model, different concentrations taraxasterol (0, 1, 5, 10, 20 μg/mL) protect against DON-induced cell damage. The results...
Persistent infection with high-risk human papillomavirus (HR-HPV) is the most important determinate in development of cervical cancer, and microecology can modulate viral infection. However, few studies have been conducted on microecological analysis diseases using strict physiological factors. This study investigated characteristics dynamics childbearing-age Chinese women different degrees HR-HPV-positive lesions. A total 168 subjects were selected according to selection criteria, including...
Abstract Background Trisomy 21 is a common aneuploid condition in humans and accounts for approximately one quarter of all live births. To date, early diagnosis remains challenging task. Metabolomics may prove an innovative tool to study the pathophysiology at functional level. Methods Ultra‐performance liquid chromatography coupled with mass spectrometer (UPLC‐MS) was used untargeted metabolomic analysis amniotic fluid samples from women having normal trisomy fetuses. Results Many...
Abstract A novel sterol mesylate compound (NSC67657) was recently identified and reported by National Cancer Institute that could efficiently induce the differentiation of HL60 cells into monocytes in vitro vivo . The expression many proteins would have been changed during process, some may played key roles cell line induced this drug. Therefore, we treated with NSC67657 all‐trans retinoic acid (ATRA) to identify differentially expressed determine their functions cellular differentiation. Of...
To analyze the characteristics of cervical microecology in late reproductive-age women with lesions and explore new methods for preventing lesions.