A5010381184- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Nosocomial Infections in ICU
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Metabolism and Genetic Disorders
- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- Cancer-related gene regulation
- Autoimmune and Inflammatory Disorders Research
- Drug-Induced Adverse Reactions
- PI3K/AKT/mTOR signaling in cancer
- Diet and metabolism studies
- Celiac Disease Research and Management
- Mitochondrial Function and Pathology
- Sexual function and dysfunction studies
- Prenatal Screening and Diagnostics
- Genetic Syndromes and Imprinting
- Media Influence and Politics
- Autoimmune and Inflammatory Disorders
- Fungal and yeast genetics research
- Personality Disorders and Psychopathology
- Potassium and Related Disorders
Boston University
2023
Mayo Clinic
2017-2022
WinnMed
2021-2022
Neurobehavioral Systems
2022
Mayo Clinic Hospital
2022
Mayo Clinic in Arizona
2016-2021
University of California, San Francisco
2020-2021
Stephen F. Austin State University
2020-2021
University of Minnesota Rochester
2020
Texas Tech University
2020
Abstract Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an of anaerobes, does not correspond patient symptoms, may be a result dietary preferences. microbial composition, the other hand, is significantly altered symptomatic patients results. In...
Copy Number Variations (CNVs) and Single Nucleotide Polymorphisms (SNPs) have been the major focus of most large-scale comparative genomics studies to date. Here, we discuss a third, largely ignored, type genetic variation, namely changes in tandem repeat number. Historically, repeats designated as non functional "junk" DNA, mostly result their highly unstable nature. With exception involved human neurodegenerative diseases, variation was often believed be neutral with no phenotypic...
Occult hernias are symptomatic but not palpable on physical examination. This is more commonly seen with inguinal hernias. Early diagnosis and treatment of occult essential in relieving symptoms improving patients' quality life.To determine the effectiveness imaging-ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI)--in hernia.A retrospective medical records review surgical patients groin pelvic pain, 2008-2013, was conducted a single-surgeon hernia specialty...
Alpelisib selectively inhibits the p110α catalytic subunit of PI3Kα and is approved for treatment breast cancers harboring canonical PIK3CA mutations. In head neck squamous cell carcinoma (HNSCC), 63% mutations occur at hotspots. The oncogenic role remaining 37% noncanonical incompletely understood. We report a patient with HNSCC mutation (Q75E) who exhibited durable (12 months) response to alpelisib in phase II clinical trial. Characterization all 32 found using several functional...
Background: Fecal microbiota transplantation (FMT) is a successful therapy for Clostridioides difficile infection (CDI). FMT from overweight donors speculated to influence the recipient’s body mass index (BMI) after administration CDI. Objectives: We investigated changes in BMI relation donor’s BMI. Design: conducted retrospective cohort study involving patients who underwent recurrent CDI at Mayo Clinic between 2012 and 2019. Methods: analyzed demographic donor data undergoing (2012–2019)....
Genomic imprinting is an epigenetic inheritance system characterized by parental allele-specific gene expression. Allele-specific DNA methylation and chromatin composition are two modification systems that control imprinted To get a general assessment of histone lysine acetylation at genes we measured wide range residues, H3K4, H3K18, H3K27, H3K36, H3K79, H3K64, H4K5, H4K8, H4K12, H2AK5, H2BK12, H2BK16 H2BK46 11 differentially methylated regions (DMRs) in reciprocal mouse crosses using...
Abstract Background Current approaches in tracking Clostridioides difficile infection (CDI) and individualizing patient management are incompletely defined. Methods We recruited 468 subjects with CDI at Mayo Clinic Rochester between May December 2016 performed whole-genome sequencing (WGS) on C. isolates from 397. WGS was also a subset of the time recurrence infection. The sequence data were analyzed by determining core genome multilocus type (cgMLST), grouped allelic differences predicted...
Abstract Background Conflicting data have been published on whether an association exists between atopic dermatitis ( AD ) and nonmelanoma skin cancer. This study aimed to determine individuals with had increased risk of squamous cell carcinoma SCC development. Methods We conducted a retrospective, case–control patients residing in Olmsted County, Minnesota. Cases were selected from seen at Mayo Clinic (Rochester, Minnesota) who initial diagnosis (either invasive or situ January 1, 1996,...
Fibrolamellar hepatocellular carcinoma (fHCC) is a rare primary liver cancer that affects young adults with no prior disease. fHCC-associated hyperammonemic encephalopathy (HAE) an uncommon and life-threatening complication. Hyperammonemia has been reported in both typical fHCC as result of intrahepatic shunting, side effect from immunotherapy or chemotherapy, paraneoplastic phenomenon. We present case 32-year-old woman recurrent metastatic who developed HAE the setting steroid...
This study examines reporting on protests in Iran between late December 2017 and early January 2018 by global news agencies located the United States (Associated Press [AP]), Kingdom (Reuters), France (Agence France-Presse [AFP]), China (Xinhua), Russia (Telegraph Agency of Soviet Union [TASS]). A census ( N = 369) was content analyzed. Results demonstrate that varied considerably their portrayal issues defined as problems, diagnosis causes, moral evaluations, treatment recommendations....
INTRODUCTION: Vulvar involvement is a rare complication of Crohn's disease (CD). The optimal treatment vulvar CD unknown. METHODS: We conducted 25-year retrospective cohort study from 3 referral centers. Clinical features and outcomes were studied. RESULTS: Fifty patients identified. most common symptoms pain (74%), edema (60%), ulcerations (46%), nodules (36%), abscess (34%). Medical management leading to symptomatic improvement varied, 5 ultimately required surgery. DISCUSSION: manifests...
ypectomy during colonoscopy for FMT.This study was approved by the Mayo Clinic Institutional Review Board (IRB No. 14-005326) and patients were consented follow-up.This retrospective cohort evaluated who underwent FMT recurrent CDI through between August 2012 September 2015.Data obtained from electronic health record.Collected data included demographic characteristics, prior GI tract diagnoses, findings, including macroscopic diagnoses biopsy results.Prior classified as IBD, microscopic...
Background Tinnitus distress is related to both the loudness and intrusiveness of tinnitus percept. Treatment approaches targeting attentional/limbic auditory systems may better alleviate than system alone. Materials Methods Ten subjects with chronic received sequential rTMS treatment involving: 1) excitatory stimulation administered left dorsolateral prefrontal cortex (DLPFC) or inhibitory right DLPFC, followed by 2) primary (Heschel's gyrus HG). A systematic literature review was performed...
An inaccurate definition of what constitutes sex can negatively impact the sexual health and wellbeing patients. This study aimed to determine which behaviors medical students consider be sex. Survey questions about various were administered students. All participants agreed that penile-vaginal penetration is More than 25% did not genital-genital contact without penetration, oral-genital contact, foreign object in rectum, forced vaginal/rectal as Nonheterosexuals more likely We determined...
University educators and administrators have used Journalism & Mass Communication Educator as an outlet to share ideas. As the journal enters its 75th year of publication, it is also decades into transition peer review. Thus, important review publication trends since this development. This study analyzes 30 years research articles printed from 1990 2019. Aspects article authorship are examined reveal in history. Results demonstrate growing amount diversity across a number aspects remains...
Metastatic melanoma is often found in the gastrointestinal tract. The most common sites are liver and small bowel but less commonly metastases can be stomach. We present a patient with metastatic to gastric body who presented moderate normocytic anemia. A 60-year-old male had background 7 year history of malignant right chest wall, left axillary lymph nodes, breast, lower lung. All disease was treated surgical resection. In routine follow-up, he minimal bright red blood per rectum new He no...