A5101786569- Phytoestrogen effects and research
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Sarcoma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
- NF-κB Signaling Pathways
- Bone Metabolism and Diseases
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Metabolomics and Mass Spectrometry Studies
- Electrolyte and hormonal disorders
- Cancer Mechanisms and Therapy
- Renal cell carcinoma treatment
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Biochemical and Molecular Research
- TGF-β signaling in diseases
- Acute Kidney Injury Research
- Effects of Radiation Exposure
- Histone Deacetylase Inhibitors Research
- Bioactive Compounds and Antitumor Agents
- RNA Research and Splicing
Central South University
2022-2024
Second Xiangya Hospital of Central South University
2024
Chongqing Three Gorges University
2024
Chongqing University
2024
Wuhan University
2018-2022
Zhongnan Hospital of Wuhan University
2018-2022
Sichuan University
2022
Memorial University of Newfoundland
2022
Army Medical University
2022
Chengdu Medical College
2022
In this study, The Cancer Genome Atlas and Genotype-Tissue Expression databases were used to identify potential biomarkers of soft tissue sarcoma (STS) construct a prognostic model.The model was calculate risk scores based on the expression five key genes, among which MYBL2 FBN2 upregulated TSPAN7, GCSH, DDX39B downregulated in STS patients.We also examined gene signatures associated with genes evaluated model's clinical utility.The found be involved cell cycle, DNA replication, various...
Low response rates to immunotherapy have been reported in soft tissue sarcoma (STS). There are few predictive biomarkers of response, and the tumor immune microenvironment associated with progression prognosis remains unclear STS. Gene expression data from Cancer Genome Atlas were used identify immune-related prognostic genes (IRPGs) construct gene-related model (IGRPM). The was characterized reveal differences between patients different prognoses. Furthermore, somatic mutation DNA...
Dysregulated osteoclast activity due to altered differentiation causes multiple bone diseases. Osteoclasts are multinucleated giant cells derived from hematopoietic stem and play a major role in absorption. However, the mechanisms underlying tight regulation of pathophysiological status remain unknown.We showed that Bhlhe40 upregulation is tightly associated with osteoporosis. Functionally, promoted vitro, deficiency led increased mass decreased vivo. Moreover, deficient mice resisted...
Abstract Objective The purpose of this study is to explore the effect miRNA-539 on osteosarcoma (OS) and underlying mechanism, so as find a new method for early diagnosis treatment osteosarcoma. Method mimics was transfected into cells 143b MG-63 upregulated expression miR-539. QT-PCR used detect transfection efficacy. CCK-8 proliferation flow cytometry apoptosis MG-63. Wound-healing test Transwell were migration invasion ability cells. TRIAP1 found be potential target gene by online...
Abstract Background Patients with bipolar disorder (BD) show abnormalities in glucolipid metabolism and reproductive hormone levels, which are of concern women BD. This study was dedicated to investigating the levels female patients, preliminarily their relationships cognition. Methods A total 58 unmedicated BD 61 stable-medicated 63 healthy controls (HC) were recruited this study. Serum glycolipid indexes hormones measured. Cognitive function assessed using Repeatable Battery for Assessment...
RNA-binding proteins (RBPs) have been shown to be dysregulated in cancer transcription and translation, but few studies investigated their mechanism of action soft tissue sarcoma (STS). Here, The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases were used identify differentially expressed RBPs STS normal tissues. Through a series biological information analyses, 329 identified. Functional enrichment analysis showed that mainly involved RNA transport, splicing, mRNA...
Bone resorption diseases, including osteoporosis, are usually caused by excessive osteoclastogenesis. Unc‐51‐like autophagy activating kinase 1 (ULK1), a mammalian serine/threonine kinase, may participate in the regulation of bone homeostasis and osteolytic metastasis. In this study, ULK1 expression during osteoclastogenesis was detected with RT‐PCR. We knocked down or overexpressed through siRNA lentiviral transduction marrow macrophage (BMM). TRAP phalloidin staining were performed to...
This study aims to explore the effect of daidzein, which is a natural isoflavone compound mainly extracted from soybeans, on osteosarcoma and potential molecular mechanism.143B U2OS cells were treated with gradient concentrations MTT assay was used determine cell proliferation capacity IC50. Hoechst 33342 staining Annexin V-FITC/PI detection apoptosis. Cell cycle analyzed by flow cytometry, migration ability detected transwell assays scratch wound assay. An xenograft mice model applied...
Background: N6-methyladenosine (m6A) methylation played a key role in tumor growth. However, the relationship between m6A and soft tissue sarcoma (STS) was still unclear. Methods: The characterization patterns of modification STS (TCGA-SARC GSE17674) were analyzed comprehensively through bioinformatics real-time polymerase chain reaction (RT-PCR). effects different on prognosis immune infiltration further explored. Differentially expressed gene (DEG) analysis performed. Moreover, an m6Ascore...
The present study investigated the Zinc finger BED-type containing 3 (ZBED3) mRNA expression levels, diagnostic and prognostic values, co-expressed differentially expressed genes, immune infiltration, functional enrichment analysis in patients with kidney renal clear cell carcinoma (KIRC) using various public databases such as Cancer Genome Atlas, Genotype-Tissue Expression Project, LinkedOmics, Gene Set Enrichment Analysis databases, Xiantao academic tool. Through extensive data mining, our...
Radiation-induced bone injury (RIBI) is one of the complications after radiotherapy for malignant tumors. However, there are no effective measures treatment RIBI in clinical practice, and mechanism unclear. We use a single high-dose ionizing radiation (6Gy) to analyze effect on osteoblast function. Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) were cocultured with irradiated osteoblasts examine their therapeutic effects mechanisms injury. The hUCB-MSC transplantation mouse...
Objective To investigate the effect and mechanism of microRNA (miRNA, miR)-126-3p on inflammatory response after spinal cord injury in rats. Methods The SD rat model was established. The relative expression miR-126 tissues 3, 7 14 d rats detected by real-time fluorescent quantitative polymerase chain reaction (FQ-PCR). agomir-126 injection motor function with acute evaluated Basso-Beattie-Bresnahan (BBB) scoring method, online target gene used to predict database Targetscan....