A5066905264- Bone Tissue Engineering Materials
- Additive Manufacturing Materials and Processes
- Additive Manufacturing and 3D Printing Technologies
- Titanium Alloys Microstructure and Properties
- Orthopaedic implants and arthroplasty
- Magnesium Alloys: Properties and Applications
- Anesthesia and Sedative Agents
- Machine Learning in Materials Science
- 3D Printing in Biomedical Research
- Extracellular vesicles in disease
- Risk and Safety Analysis
- Bone Metabolism and Diseases
- Treatment of Major Depression
- MXene and MAX Phase Materials
- Human-Automation Interaction and Safety
- Occupational Health and Safety Research
- Anesthesia and Pain Management
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Cellular and Composite Structures
- Electrospun Nanofibers in Biomedical Applications
- Orthopedic Infections and Treatments
Tsinghua University
2022-2025
Changzhou No.2 People's Hospital
2024
Nanjing Medical University
2024
State Key Laboratory of Tribology
2023
Qufu Normal University
2021
Wannan Medical College
2020
Abstract Architected materials that consist of multiple subelements arranged in particular orders can demonstrate a much broader range properties than their constituent materials. However, the rational design these generally relies on experts’ prior knowledge and requires painstaking effort. Here, we present data-efficient method for high-dimensional multi-property optimization 3D-printed architected utilizing machine learning (ML) cycle consisting finite element (FEM) 3D neural networks....
Abstract Reconciling the dilemma between rapid degradation and overdose toxicity is challenging in biodegradable materials when shifting from bulk to porous materials. Here, we achieve significant bone ingrowth into Zn-based scaffolds with 90% porosity via osteoinmunomodulation. At microscale, an alloy incorporating 0.8 wt% Li employed create a eutectoid lamellar structure featuring LiZn 4 Zn phases. This microstructure optimally balances high strength immunomodulation effects. mesoscale,...
Zinc (Zn) alloy porous scaffolds produced by additive manufacturing own customizable structures and biodegradable functions, having a great application potential for repairing bone defect. In this work, hydroxyapatite (HA)/polydopamine (PDA) composite coating was constructed on the surface of Zn-1Mg fabricated laser powder bed fusion, loaded with bioactive factor BMP2 an antibacterial drug vancomycin. The microstructure, degradation behavior, biocompatibility, performance osteogenic...
Abstract The combination of bioactive Zn‐2Mg alloy and additively manufactured porous scaffold is expected to achieve customizable biodegradable performance enhanced bone regeneration. Herein, scaffolds with different porosities, including 40% (G‐40‐2), 60% (G‐60‐2), 80% (G‐80‐2), unit sizes, 1.5 mm (G‐60‐1.5), 2 2.5 (G‐60‐2.5), are by a triply periodic minimal surface design reliable laser powder bed fusion process. With the same size, compressive strength (CS) elastic modulus (EM)...
Additively manufactured biodegradable zinc (Zn) scaffolds have great potential to repair infected bone defects due their osteogenic and antibacterial properties. However, the enhancement of properties depends on a high concentration dissolved Zn
Abstract Postoperative therapies for osteosarcoma present substantial challenges due to tumor recurrence and extensive bone defects. To tackle these challenges, laser powder bed fusion is utilized fabricate biodegradable Zn‐Li porous scaffolds that supress tumors promote osteogenesis. After the structure design composition selection, Zn‐0.8Li scaffold with Gyroid unit optimally balances co‐release of Zn 2+ Li + during degradation, resulting in favorable antitumor osteogenic effects. In...
Previous studies have reported conflicting findings regarding the efficacy of esketamine in managing postoperative depression. While positive effects subanesthetic doses been observed treatment-resistant depression, response to this medication patients experiencing depression following surgery has not consistent. Building upon known impact anesthesia on brain function, we formulated a hypothesis suggesting that timing administration relation may significantly affect its The aim study was...
Abstract Architected materials that consist of multiple subelements arranged in particular orders can demonstrate a much broader range properties than their constituent materials. However, the rational design these generally relies on experts' prior knowledge and requires painstaking effort. Here, we present data-efficient method for multi-property optimization 3D-printed architected utilizing machine learning (ML) cycle consisting 3D neural networks finite element (FEM). Specifically,...