A5102979193- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- 2D Materials and Applications
- MXene and MAX Phase Materials
- Radiomics and Machine Learning in Medical Imaging
- Perovskite Materials and Applications
- Colorectal Cancer Treatments and Studies
- Cardiac Structural Anomalies and Repair
- Graphene research and applications
- Multiferroics and related materials
- Gastric Cancer Management and Outcomes
- Signaling Pathways in Disease
- Quantum Dots Synthesis And Properties
- Advanced Photocatalysis Techniques
- Cancer, Hypoxia, and Metabolism
- Conducting polymers and applications
- Lymphoma Diagnosis and Treatment
- Ferrocene Chemistry and Applications
- Dendrimers and Hyperbranched Polymers
- Phenothiazines and Benzothiazines Synthesis and Activities
- Esophageal Cancer Research and Treatment
- Graphene and Nanomaterials Applications
- Dielectric properties of ceramics
Fudan University
2017-2025
Fudan University Shanghai Cancer Center
2018-2025
Shanghai Medical College of Fudan University
2018-2025
Chung Yuan Christian University
2024
Center for High Pressure Science & Technology Advanced Research
2024
Proton (Malaysia)
2023
East China Normal University
2018-2021
Shanxi University
2019-2021
Laboratoire d’Imagerie Biomédicale
2018
National United University
2014
Engineering the electronic band structure of material systems enables unprecedented exploration new physical properties that are absent in natural or as-synthetic materials. Half metallicity, an intriguing property arising from metallic nature electrons with singular spin polarization and insulating for oppositely polarized electrons, holds a great potential 100% spin-polarized current high-efficiency spintronics. Conventionally synthesized thin films hardly sustain half metallicity...
Our work introduces an emerging route for the synthesis of MoS<sub>2</sub> nanoflowers decorating organ-like Mo<sub>2</sub>CT<sub>x</sub> MXene. This effective strategy MoS<sub>2</sub>@Mo<sub>2</sub>CT<sub>x</sub> nanohybrid structure can shed some light on energy-related applications.
BACKGROUND. Improving and predicting tumor response to immunotherapy remains challenging. Combination therapy with a transforming growth factor-β receptor (TGF-βR) inhibitor that targets cancer associated fibroblasts (CAFs) is promising enhance efficacy of immunotherapies. However, the effect this approach in clinical trials limited, requiring vivo methods better assess responses combination therapy.
Abstract Background The aim of this study was to evaluate the efficacy fluorine 18 ( F) labeled fibroblast activation protein inhibitor (FAPI) in identifying mediastinal and hilar lymph node metastases develop a model quantitatively repeatedly identify status. Methods Twenty-seven patients with 137 nodes were identified by two PET/CT images. sensitivity, specificity, accuracy, positive predictive value (PPV), negative (NPV) status analyzed, optimal cut-off ROC analysis. Results SUVmax...
This study aimed to develop and evaluate a novel fibroblast activation protein (FAP)-specific tracer, fluorine-18-labeled inhibitor-FUSCC-07 ([18F]F-FAPI-FUSCC-07), for use in both preclinical clinical settings. Preclinical evaluations were conducted assess the stability partition coefficient of [18F]F-FAPI-FUSCC-07. Experiments involving human glioma U87MG cells demonstrated its cellular uptake inhibitory properties. Further investigations included biodistribution analysis micropositron...
Nectin cell adhesion molecule 4 (Nectin-4) is an emerging biomarker for cancer diagnosis and therapy. We developed a Nectin-4-targeted 68Ga-DOTA-Sar10-Nectin-4 (68Ga-FZ-NR-1) PET/CT radiotracer detecting Nectin-4 expression in tumor model triple-negative breast (TNBC) patients. Methods: A series of radiotracers-68Ga-FZ-NR-1, 68Ga-DOTA-polyethylene glycol 5-Nectin-4 (68Ga-FZ-NR-2), 10-Nectin-4 (68Ga-FZ-NR-3)-were synthesized, their targeting ability specificity were evaluated vitro vivo. In...
Objectives The accurate assessment of lymph node metastases (LNMs) and the preoperative nodal (N) stage are critical for precise treatment patients with gastric cancer (GC). diagnostic performance, however, current imaging procedures used this is sub-optimal. Our aim was to investigate value 18 F-FDG PET/CT radiomic features predict LNMs N stage. Methods We retrospectively collected clinical data 185 GC who underwent total or partial radical gastrectomy. Patients were allocated training...
A composite of MoS<sub>2</sub>/Nb<sub>2</sub>CT<sub>x</sub> with MoS<sub>2</sub> nanoflowers grown between Nb<sub>2</sub>CT<sub>x</sub> flakes for electrolysis water in acidic and alkaline solutions.
We aimed to establish and validate 2 machine learning models using 18F-flurodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) radiomic features predict human epidermal growth factor receptor (HER2) expression prognosis in gastric cancer (GC) patients.We retrospectively enrolled 90 patients diagnosed with GC, including their clinical information the 18F-FDG PET/CT images. Patients were allocated a training cohort of 72 an independent validation (IVC) 18 patients....
The aim of this study was to investigate the predictive value early changes in 18 F-fluoroestradiol (FES) positron emission tomography (PET)/computed (CT) during fulvestrant 500 mg therapy patients with estrogen receptor (ER)-positive metastatic breast cancer.Patients underwent F-FES PET/CT scans at both baseline (scan 1) and day 28 2). maximum standardized uptake (SUVmax) all sites determined each scan, percentage reduction SUVmax (ΔSUVmax) calculated as [(SUVmax on scan 1-SUVmax 2)/ 1] *...
The structure and valley splitting of antiferromagnetic heterostructure MnPSe<sub>3</sub>/WSe<sub>2</sub>.
Background Breast cancer is a heterogeneous disease, and the human epidermal growth factor receptor 2 (HER2) expression may vary considerably between primary metastatic lesions, or even within single lesion. Repeated biopsies cannot always be performed. In this feasibility trial, we assessed whether novel 68 Ga-NOTA-MAL-MZHER2 ( Ga-HER2) affibody PET/CT could determine HER2 status of each lesion if there was clinical need for it. Methods Ga-HER2 performed in breast patients remained unclear...
The ferromagnetism of the two dimensional (2D) Cr2Ge2Te6 atomic layers with perpendicular magnetic anisotropy and Curie temperature 30-50 K has recently been experimentally confirmed. By performing density-functional theory calculations, we demonstrate that properties bilayer can be flexibly tailored, due to effective band structure tuning by external electric field. field induces semiconductor-metal transition redistributes charge spin between layers. Furthermore, energy obviously enhanced...
Ferroelectrics have long been recognized as one of the candidate class materials for applications in photovoltaic devices. Recently, ferroelectric perovskite $(\text{K},\text{Ba})(\text{Ni},\text{Nb}){\mathrm{O}}_{3\ensuremath{-}\ensuremath{\delta}}$ has successfully synthesized and demonstrated to a near-optimal band gap (1.39 eV), exhibiting good performance. However, connection between structural order-disorder transformation, electronic structure, bulk photovoltaic, photocatalytic...
PEGylated ultrasmall nanographene oxide (usNGO-PEG) has exhibited a great potential in nanotheranostics due to its newly discovered physicochemical properties derived from the rich functional groups and bonds. Herein, we developed general, simple, kitlike preparation approach for 99mTc- Gd-anchored NGO-PEG using chelator-free strategy. In this strategy, [99mTcI(CO)3(OH2)3]+ (abbreviated 99mTcI) GdCl3 were mixed with usNGO-PEG yield Gd-usNGO-PEG via synergistic coordination of N O atoms NGO...
Cisplatin has limited clinical applications due to drug resistance. PAMAM dendrimer was chosen as a vehicle counteract cisplatin-resistance and its mechanism assessed.Generation 5 Polyamidoamine (G5) modified by glutaric anhydride (GA) then conjugated with cisplatin. The cisplatin release of G5-GA-cisplatin evaluated at pH 5.5 7.4. cytotoxicity free compared in cisplatin-resistant breast cancer cell line MCF-7R. intracellular platinum content MCF-7R determined using ICP-MS. expression Ctr1...
Abstract A 67-year-old woman who was diagnosed with intrahepatic cholangiocellular carcinoma (CCC) by biopsy underwent 18 F-FDG and F-AIF-FAPI-04 PET/CT for initial treatment assessment. In addition to CCC, she had a history of hepatic hemangioma 3 years. images showed increased uptake in but no hemangiomas. However, on indicated negative intense activity Our case illustrates that demonstrated uptake, final diagnosis should be made caution.
In this study, the uptake characteristics of [18F]fibroblast activation protein inhibitor (FAPI) molecular imaging probe were investigated in acute radiation pneumonia and lung cancer xenografted mice before after to assess future applicability [18F]FAPI positron emission tomography/computed tomography (PET/CT) early radiotherapy response. Initially, biodistribution tracer vivo studied healthy at each time-point. A comparison [18F]fluorodeoxyglucose (FDG) PET/CT efficacy normal ICR, LLC...
Purpose To investigate the clinical impact and prognostic value of gallium 68 (
Abstract Introduction The aim of our study was to investigate the effect a ‘virtual experience’ on reducing people’s anxiety levels and improving image quality. Methods This included 200 people who underwent 18 F‐FDG PET/CT scan for first time. Healthy ( n = 100) patients were randomly divided into control group an intervention group. In group, we used as before scan. We Spielberger State‐Trait Anxiety Inventory (STAI) satisfaction questionnaires evaluation. Additionally, quality analysed....
Although various kinds of nanomaterials have been used as anticancer theranostics by exploiting the tumor microenvironment, relatively few can be efficiently activated redox status for imaging and therapy. Oxygen-deficient tungsten-based oxides or bronzes are appearing new classes near-infrared (NIR)-responsive due to their unique properties such tunable broad NIR absorption. Herein, we synthesized PEG-Na x WO3 nanorods (NRs) a simple thermal decomposition method investigated redox-activated...