A5035201302- Craniofacial Disorders and Treatments
- Hormonal Regulation and Hypertension
- Natural Compounds in Disease Treatment
- Metabolism and Genetic Disorders
- Cancer Mechanisms and Therapy
- Immunodeficiency and Autoimmune Disorders
- Cleft Lip and Palate Research
- Soft tissue tumor case studies
- Genetic Syndromes and Imprinting
- Birth, Development, and Health
- dental development and anomalies
Wuhan University
2018-2025
ABSTRACT Fibroblast growth factor 23 (FGF23), primarily secreted by osteocytes and osteoblasts, is essential in regulating phosphate‐calcium metabolism inhibiting renal phosphate reabsorption vitamin D synthesis. Acute kidney injury (AKI) characterized a rapid deterioration function, accompanied significant increase FGF23 levels, which contribute to its severity progression. This study investigated the mechanistic roles of Gαq Gα11 proteins, integral components lysophosphatidic acid (LPA)...
The 3 major subphenotypes observed in patients with nonsyndromic orofacial clefts (NSOFCs) are cleft lip only (NSCLO), palate (NSCLP), and (NSCPO). However, the genetic architecture underlying NSCPO is largely unknown. Here we performed a 2-stage genome-wide association study (GWAS) on replication analyses of selected variants other NSOFCs from Chinese Han population. We identified novel locus (15q24.3) known (1q32.2) where or near gene reached significance (2.80 × 10 −13 < P 1.72 −08 )...
To identify the role of astrocyte elevated gene-1 (AEG-1) and mechanism underlying inflammatory response in dental pulp cells.Astrocyte expression was detected at different stages pulpitis a rat model using immunohistochemistry. RT-qPCR Western blot were used to assess AEG-1 human cells stimulated by lipopolysaccharide (LPS). The LPS-induced cytokine genes quantified transfected with or negative control (NC) siRNA. Immunofluorescence utilized evaluate activation NF-κB signalling knockdown...
Chronic kidney disease (CKD) presents a critical global health challenge, marked by the progressive decline of renal function. This study explores role 3β-hydroxysteroid dehydrogenase type 2 enzyme (HSD3B2) and steroid hormone biosynthesis pathway in CKD pathogenesis progression.