A5058532609- Reproductive Biology and Fertility
- Animal Nutrition and Physiology
- Effects and risks of endocrine disrupting chemicals
- Reproductive System and Pregnancy
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Genetically Modified Organisms Research
- Epigenetics and DNA Methylation
- Animal Genetics and Reproduction
- Ovarian function and disorders
- Nuclear Receptors and Signaling
- Extracellular vesicles in disease
- Plant Micronutrient Interactions and Effects
- Respiratory and Cough-Related Research
- Weed Control and Herbicide Applications
- Pesticide and Herbicide Environmental Studies
- Reproductive biology and impacts on aquatic species
- Aldose Reductase and Taurine
- Agriculture and Biological Studies
- Nicotinic Acetylcholine Receptors Study
- Developmental Biology and Gene Regulation
- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Curcumin's Biomedical Applications
Peking University
2024
Beijing Obstetrics and Gynecology Hospital
2024
Peking University Third Hospital
2024
Ministry of Education of the People's Republic of China
2024
Shandong Tumor Hospital
2023
Academy of Medical Sciences
2023
Shandong First Medical University
2023
Anhui Medical University
2022
Qingdao Agricultural University
2013-2022
Southern Medical University
2017-2022
Abstract Premature ovarian failure (POF) is a leading cause of women’s infertility without effective treatment. Here we show that intravenous injection Ab4B19, an agonistic antibody for the BDNF receptor TrkB, penetrates into follicles, activates TrkB signaling, and promotes ovary development. In both natural aging cyclophosphamide-induced POF models, treatment with Ab4B19 completely reverses reduction pre-antral antral normalizes gonadal hormone. also attenuates gonadotoxicity inhibits...
Microplastics (MPs) are ubiquitous in global ecosystems and may pose a potential risk to human health. However, critical information on MP exposure female reproductive health is still lacking. In this study, we characterized MPs endometrium investigated their size-dependent entry mode as well toxicity. Endometrial tissues of 22 patients were examined, revealing that was contaminated with MPs, mainly polyamide (PA), polyurethane (PU), polyethylene terephthalate (PET), polypropylene (PP),...
Bisphenol‐A (BPA) and diethylhexyl phthalate (DEHP) are estrogenic compounds widely used in commercial plastic products. Previous studies have shown that exposure to such adverse effects on various aspects of mammalian reproduction including folliculogenesis. The objective this study was examine the BPA DEHP primordial follicle formation. We found germ cell nest breakdown assembly were significantly reduced when newborn mouse ovaries exposed 10 or 100 μM vitro. Moreover, increased number...
Abstract Understanding the unique mechanisms of human oogenesis necessitates development an in vitro system stem cell differentiation into oocytes. Specialized types and organoids have been derived from pluripotent cells , but generating a ovarian follicle remains challenge. Here we report that embryonic can be induced to differentiate follicle-like (FLCs) . First, find two RNA-binding proteins specifically expressed germ cells, DAZL BOULE, regulate exit pluripotency entry meiosis. By...
Oxidative stress (OS), as a signal of aberrant intracellular mechanisms, plays key roles in maintaining homeostasis for organisms. The occurrence OS due to the disorder normal cellular redox balance indicates overproduction reactive oxygen species (ROS) and/or deficiency antioxidants. Once is broken down, repression oxidative one most effective ways alleviate it. Ongoing studies provide remarkable evidence that involved reproductive toxicity induced by various stimuli, such environmental...
A critical process of early oogenesis is the entry mitotic oogonia into meiosis, a cell cycle switch regulated by complex gene regulatory network. Although Notch pathway involved in numerous important aspects invertebrate species, whether it plays roles events mammals unknown. Therefore, rationale present study was to investigate signaling crucial processes oogenesis, such as meiosis and oocyte growth. receptors ligands were localized mouse embryonic female gonads 2 inhibitors, namely DAPT...
Abstract Glyphosate‐based herbicides (GBHs) are a group of widely used broad‐spectrum agricultural pesticides. Due to the recalcitrance GBH, it has been found in food and environment as contaminant, posing threat public health. The health risks associated with GBH have indicated by reporting acute toxicity data (an exposure at 0.5% dose), which primarily discuss relation accidental high‐rate exposure. Currently, there is little information regarding environmentally relevant levels. In this...
Three experiments were conducted using aged broiler breeder hens (greater than 60 wk) to investigate the effects of supplemental B on egg production (EP), shell quality, and Ca metabolism. Experiment 1 had a 2 x factorial arrangement treatments: 1) high (3.5%); 2) plus B; 3) low (1.5%); 4) 32 60-wk-old hens. The levels basal 100 ppm for first wk experiment reduced remaining 3 wk. Egg production, thickness (ST), specific gravity (SG) recorded weekly. In 2, 40 divided into two groups: quality....
In the present paper, we found that human fetal ovaries (at ~16 weeks) express transcripts for several subunits of nicotinic acetylcholine receptor (nAChR). Exposure to drug in vitro resulted marked increase apoptosis a time and dose-dependent manner. Evidence adverse nicotine effects are potentially due an increased level reactive oxygen species (ROS) consequent DNA damage, both ovarian somatic cells germ cells, reported. After 4 days culture, exposure 1 mM 10 caused 50% 75% decrease,...
Abstract Impaired endometrial function and reduced receptivity remain significant causes of female infertility. Here, a sprayable hydrogel combined with human organoid extracellular vesicles (HEO‐EVs) is developed to enhance uterine preservation fertility restoration. The peptide amphiphile (labeled CPA) engineered by conjugating collagen‐binding glutathione impart its biocompatible adhesive antioxidant properties. therapeutic EVs are isolated purified from organoids that have been stably...
Objective: To observe the compliance, efficacy and safety of subcutaneous immunotherapy(SLIT) sublingual immunotherapy(SCIT) in patients with allergic rhinitis(AR).Method:One hundred fifteen sensitized to house dust mites were recruited this study. The standardized extract was used for SLIT 64 cases, dual SCIT other 51 cases. nasal symptom scores, medication quality life adverse reaction evaluated before 2 years after immunotherapy. SPSS 19.0 data analysis. Result:Forty out completed...
Abstract STUDY QUESTION What is the pathological mechanism involved in a thin endometrium, particularly under ischaemic conditions? SUMMARY ANSWER Endometrial dysfunction patients with endometrium primarily results from remodelling cytoskeletons and cellular junctions of endometrial epithelial cells ischemic conditions. WHAT IS KNOWN ALREADY A healthy essential for successful embryo implantation subsequent pregnancy; conditions compromise fertility outcomes. DESIGN, SIZE, DURATION We...