A5058574573- Landslides and related hazards
- RNA Research and Splicing
- Ethics and Social Impacts of AI
- Bioinformatics and Genomic Networks
- Topic Modeling
- Flood Risk Assessment and Management
- Long-Term Effects of COVID-19
- Cryospheric studies and observations
- Dam Engineering and Safety
- Animal Genetics and Reproduction
- COVID-19 Clinical Research Studies
- Alzheimer's disease research and treatments
- Sperm and Testicular Function
- Natural Language Processing Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Dementia and Cognitive Impairment Research
- Hydrology and Sediment Transport Processes
- Adversarial Robustness in Machine Learning
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Traumatic Brain Injury Research
- RNA modifications and cancer
- Sepsis Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Hydrology and Watershed Management Studies
Nantong University
2006-2025
Second People's Hospital of NanTong
2020-2025
Southeast University
2023-2024
Boston University
2022-2024
Framingham Heart Study
2024
Jilin University
2015-2024
Nanjing Medical University
2023-2024
Jiangsu Province Hospital
2024
China Geological Survey
2024
Jiangsu University of Science and Technology
2024
Abstract SARS-CoV-2 is the cause of COVID-19. It infects multiple organs including respiratory tract and gut. Dynamic changes regional microbiomes in infected adults are largely unknown. Here, we performed longitudinal analyses throat anal swabs from 35 COVID-19 19 healthy adult controls, as well 10 non-COVID-19 patients with other diseases, by 16 S rRNA gene sequencing. The results showed a partitioning into 3-4 categories based on microbial community types (I-IV) both sites. bacterial...
Repetitive head impact (RHI) exposure is the chief risk factor for chronic traumatic encephalopathy (CTE). However, occurrence and severity of CTE varies widely among those with similar RHI exposure. Limited evidence suggests that APOEε4 allele may confer CTE, but previous studies were small limited scope.To test association between APOE genotype neuropathology related endophenotypes.This cross-sectional genetic study analyzed brain donors from February 2008 to August 2019 Veterans...
Abstract Since the first report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, COVID-19 pandemic has spread rapidly worldwide. Due to limited virus strains, few key mutations that would be very important with evolutionary trends genome were observed early studies. Here, we downloaded 1809 sequence data SARS-CoV-2 strains from GISAID before April 2020 identify and functional alterations caused by these mutations. Totally, identified 1017 nonsynonymous 512...
Background: Hepatocellular carcinoma (HCC) is a common malignant tumor and has poor prognosis. Minichromosome maintenance 3 (MCM3) protein upregulated in several cancers, but the biological function, molecular mechanisms relationship with immunity of MCM3 HCC remain poorly understood. Methods: The expression levels prognosis role were analyzed based on TCGA, GEO LIHC databases, 40 paired tissue samples. We conducted Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology (GO) analyses these...
Cardiac arrest (CA) is a life-threatening event with high mortality rate, and neurological injury following cardiopulmonary resuscitation (CPR) leading cause of death disability in survivors. While prolonged CPR often associated poor outcomes, there limited evidence successful recovery extended efforts. This study aims to highlight the potential for after by reporting case patient who underwent 152 minutes CPR, regained consciousness, made full recovery. The purpose explore whether advanced...
Generative models are rapidly gaining popularity and being integrated into everyday applications, raising concerns over their safe use as various vulnerabilities exposed. In light of this, the field red teaming is undergoing fast-paced growth, highlighting need for a comprehensive survey covering entire pipeline addressing emerging topics. Our extensive survey, which examines 120 papers, introduces taxonomy fine-grained attack strategies grounded in inherent capabilities language models....
Recent advances in large language models (LLMs) have shown that they can answer questions requiring complex reasoning. However, their ability to identify and respond text containing logical fallacies or deliberately misleading premises remains less studied. To address this gap, we introduce RuozhiBench, a bilingual dataset comprising 677 carefully curated contain various forms of deceptive reasoning, meticulously crafted through extensive human effort expert review. In comprehensive...
Evaluating large language models' (LLMs) long-context understanding capabilities remains challenging. We present SCALAR (Scientific Citation-based Live Assessment of Long-context Academic Reasoning), a novel benchmark that leverages academic papers and their citation networks. features automatic generation high-quality ground truth labels without human annotation, controllable difficulty levels, dynamic updating mechanism prevents data contamination. Using ICLR 2025 papers, we evaluate 8...
Subpathways, which are defined as local gene subregions within a biological pathway, have been reported to be associated with the occurrence and development of cancer. The recent subpathway identification tools generally identify differentially expressed subpathways between normal cancer samples. psSubpathway is novel systems biology R-based software package that enables flexible phenotype-specific in dataset multiple categories (such subtypes developmental stages cancer). operation modes...
We studied patients with coronavirus disease 2019 (COVID-19) infected by severe acute respiratory syndrome 2, a virus that originated in Wuhan, China, and is spreading over the country including Jiangsu Province. clinical characteristics therapies of cases
Cancer can be classified into various subtypes by its molecular, histological or clinical characteristics. Discovering cancer-subtype-specific drugs is a crucial step in personalized medicine. SubtypeDrug system biology R-based software package that enables the prioritization of subtype-specific based on cancer expression data from samples many subtypes. This provides novel approach to identify drug considering biological functions regulated at subpathway level. The operation modes include...
Melanoma, with its high degree of malignancy, stands as one the most dangerous skin cancers and remains primary cause death from cancer. With studies demonstrating potential traditional Chinese medicine to intervene treat melanoma, we turned our attention celastrol. Celastrol is a triterpene compound extracted derived Tripterygium wilfordii. Previous have shown that celastrol exerts inhibitory effects on various malignant tumors, including melanoma. Hence, goal was clarify impact cell...
Due to the speed, efficiency, relative risk, and lower costs compared traditional drug discovery, prioritization of candidate drugs for repurposing against cancers interest has attracted attention experts in recent years. Herein, we present a powerful computational approach, termed (PriorCD), cancer based on global network propagation algorithm drug-drug functional similarity constructed by integrating pathway activity profiles profiles. This provides new approach first considering...