A5103264217- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neural and Behavioral Psychology Studies
- COVID-19 and Mental Health
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- HIV-related health complications and treatments
- Mindfulness and Compassion Interventions
- Psychological Well-being and Life Satisfaction
- RNA Research and Splicing
- Neonatal Respiratory Health Research
- Behavioral Health and Interventions
- Occupational and environmental lung diseases
- Healthcare Policy and Management
- Creativity in Education and Neuroscience
- Primary Care and Health Outcomes
- MicroRNA in disease regulation
- HIV Research and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Visual perception and processing mechanisms
- Emergency and Acute Care Studies
- Multisensory perception and integration
- Aesthetic Perception and Analysis
- Bone Metabolism and Diseases
- Work-Family Balance Challenges
- Cell death mechanisms and regulation
IMT School for Advanced Studies Lucca
2021-2023
Boston Children's Hospital
2010-2023
Harvard University
2010-2023
Mater Misericordiae University Hospital
2007-2009
University College Dublin
2007-2009
Molecular Medicine Ireland
2008
University of Pisa
2004
Mindfulness interventions were shown to be effective in improving well-being and reducing perceived stress several conditions. These effects also found online mindfulness-based training, especially employees organizational environments. The aim of this study was test the effectiveness an mindfulness intervention on healthy employees, after first Italian Covid-19 lockdown. Participants group underwent 8-week training program based Mindfulness-Based Stress Reduction (MBSR) protocol compared a...
The regulation of the informational flow from mitochondria to nucleus (mitonuclear communication) is not fully characterized in heart. We have determined that mitochondrial ribosomal protein S5 (MRPS5/uS5m) can regulate cardiac function and key pathways coordinate this process during stress. demonstrate loss Mrps5 developing heart leads defects embryonic lethality while postnatal induces hypertrophy failure. structure disrupted mutant cardiomyocytes, impairing translation OXPHOS. identify...
A high incidence of decreased bone mineral density (BMD) has increasingly been associated with HIV infection. In this study mesenchymal stem cell (MSC) and human osteoblast (hOB) lines were treated tat, rev, p55-gag, gp120 HTLV env (100 ng/ml, 24 h). Cells then analyzed for calcium deposition, alkaline phosphatase (ALP) activity, lipid levels using established methods. Real-time PCR gene-specific primers was used to quantify the mRNA transcription factors RUNX-2 PPARgamma, known be...
This study is one of the first aiming at investigating mental health in post-lockdown period an Italian adult population and detecting demographic psychological predictors for a worse outcome. 1401 participants answered web-based survey including Emotional Reaction Questionnaire (ERQ), Positive Affect Negative Scale (PANAS), Impact Event Scale-Revised (IES-R), General Health (GHQ), Depression, Anxiety Stress (DASS-21), Dutch Work Addiction (DUWAS). Simple slope analyses highlighted that...
The COVID-19 evolution has forced the massive introduction of homeworking (HW) for most employees in initial stages pandemic and then return to work, mainly due vaccination campaign. These multiple abrupt adjustment demands work may be a source intense stress office workers with consequences on wellbeing quality life. This long-term prospective study aimed at investigating effect adaptation broad population large Italian banking group job-related framework. We administered web-based survey...
HIV-infected patients are at increased risk of decreased bone mineral density. Some studies have implicated antiretroviral therapy as a contributor to the density seen in treated HIV-1 patients. In this study we explore interactions between protease inhibitors (PI) and primary human osteoblast gene expression, highlighting group dysregulated genes that potentially key factors reducing formation. Runx-2 mRNA calcium deposition, alkaline phosphatase (ALP) activity significantly cultures after...
Abstract Chemokines are major regulators of the inflammatory response and have been shown to play an important role in periprosthetic osteolysis. Titanium particles previously induce IL‐8 MCP‐1 secretion osteoblasts. These chemokines result chemotaxis activation neutrophils macrophages, respectively. Despite a resurgence use cobalt‐chromium‐molybdenum alloys metal‐on‐metal arthroplasty, cobalt chromium ion toxicity area has insufficiently studied. In this study we investigate vitro effect...
Alterations in the expression of Cl
Idiopathic pulmonary fibrosis (IPF) is a refractory and lethal interstitial lung disease characterized by alveolar epithelial cells apoptosis, fibroblast proliferation, ECM protein deposition. Epstein-Barr virus (EBV) has previously been localized to of IPF patients associated with poor prognosis. In this study, we utilized microarray-based differential gene expression analysis strategy identify molecular drivers EBV-associated fibrosis. Two cell lines, primary human type 2 A549 cells, were...
The expression of Fas in thyroid tumours and Graves' disease was analysed by mRNA transcript expression. As compared with unaffected tissue, enhanced disease, adenomas, papillary follicular carcinomas. This pattern also reflected immunohistochemical studies. PCR single-strand conformational polymorphism (SSCP) method DNA sequencing were used to analyse exons 1-9. study carried out on five different histotypes (n=93) tissue from patients. a group healthy blood donors (n=64), significant...
The frontal alpha asymmetry (FAA) is a neurophysiological measure of motivation and preference. Despite the FAA associated to commercial pleasantness, conflicting evidence emerged in literature regarding its relationship with behavior. To study association between consumers' decision, we manipulated script elicit diverse attitudes decisions evaluate whether score their final investment. A little informative (S1) was used polarize investments toward unfavorable scores, while more personalized...
The quality of tissue studied impacts greatly on oligonucleotide microarray results, emphasizing the importance harvesting techniques. analyzed RNA extracted from human lung samples preserved via 4 different storage conditions (RNAlater, phosphate-buffered saline, TRIzol, liquid nitrogen). was assessed by denaturing gel electrophoresis, Agilent bioanalysis, real-time polymerase chain reaction (PCR), and Test3 Affymetrix chip hybridization. Results revealed better RNAlater electrophoresis...
Internal mobility often depends on predicting future job satisfaction, for such employees subject to internal programs. In this study, we compared the predictive power of different classes models, i.e., (i) traditional Structural Equation Modeling (SEM), with two families Machine Learning algorithms: (ii) regressors, specifically least absolute shrinkage and selection operator (Lasso) feature (iii) classifiers, Bagging meta-model k -nearest neighbors algorithm ( -NN) as a base estimator. Our...
In this study, we sought to determine the role of tRNA-derived fragments in regulation gene expression during skeletal muscle cell proliferation and differentiation. We employed culture examine function mt-Ty 5' tiRNAs. Northern blotting, RT-PCR as well RNA-Seq, were performed effects tiRNA loss gain on expression. Standard transmission electron microscopy (TEM) used characterize sub-cellular structures. 5'tiRNAs found be enriched mouse muscle, showing increased levels later developmental...
Abstract Background Idiopathic Pulmonary Fibrosis (IPF) is a progressive diffuse disease involving the lung parenchyma. Despite recent advances, molecular mechanisms of initiation and progression this remain elusive. Previous studies have demonstrated TGFβ1 as key effector cytokine in development fibrosis. Methods In study we used transgenic mouse based strategy to identify effect overexpression mediator on pulmonary fibrosis response exogenous injury. We bred two lines (line 25 18) mice...
Enhancing cognitive memory through virtual reality represents an issue, that has never been investigated in organizational settings. Here, we compared a memoryscape (treatment) – immersive environment used by subjects as shared tool based on spatial navigation with respect to the traditional individual-specific mnemonic “method of loci” (control). A task characterized high ecological validity was administered 82 employed large banking group. Memory recall measured, for both groups,...
Professional traders need to process a large amount of visual information in their daily activity judge how risky it is trade specific investment products. Despite some studies investigating the effects display clutter on traders, attention and memory were never investigated controlled experimental tasks this population. Following preliminary study with 30 participants, selective working measured compared between two groups 15 non-traders (salespeople, acting as control group) from...
A long tradition of research has shown that personality traits, such as extraversion and agreeableness, interpersonal constructs better predict job performance with a tacit but not explicit distinction in sales marketing activities. In this contribution, we aim to understand the role job-related interest data, interpersonal, traits affecting either inbound or outbound activities overall performance. An original questionnaire integrates factors reported literature (independent variables). The...