A5101935953- Estrogen and related hormone effects
- Glycosylation and Glycoproteins Research
- Cytokine Signaling Pathways and Interactions
- Reproductive Biology and Fertility
- Immune cells in cancer
- Cancer Cells and Metastasis
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Macrophage Migration Inhibitory Factor
- Carbohydrate Chemistry and Synthesis
- Genomics, phytochemicals, and oxidative stress
- Ovarian function and disorders
- Spondyloarthritis Studies and Treatments
- Endometrial and Cervical Cancer Treatments
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Galectins and Cancer Biology
- RNA Research and Splicing
- Autoimmune and Inflammatory Disorders Research
- Proteoglycans and glycosaminoglycans research
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Ovarian cancer diagnosis and treatment
- Metabolism, Diabetes, and Cancer
Shanghai First People's Hospital
2015-2025
Tongji University
2022-2025
Tongji Hospital
2022-2025
Shanghai Jiao Tong University
2013-2024
Guizhou University
2022-2024
Ontario Institute for Cancer Research
2024
China National Offshore Oil Corporation (China)
2024
Shandong Agricultural University
2023
Renji Hospital
2021-2022
University Health Network
2015-2022
Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown origin in which interleukin (IL) 17 has been genetically and therapeutically recognised as key player. Identification the cellular sources inducers IL-17 crucial our understanding drivers inflammation AS. Recently, mucosal-associated invariant T (MAIT) cells have implicated autoimmune diseases. Their gut origin, effector phenotype expression multiple AS-associated genes, such IL7R IL23R, makes them potential...
Cisplatin resistance is a major challenge in the clinical treatment of ovarian cancer, which underlying mechanisms remain unknown. The aim present study was to explore role autophagy cisplatin cancer cells. A2780cp cisplatin‑resistant carcinoma cells and A2780 parental cell line, were used as model throughout study. viability determined using water soluble tetrazolium salt‑8 assay, western blot analysis performed determine protein expression levels microtubule‑associated 1 light chain 3 (LC3...
Previously, we have demonstrated that NRF2 plays a key role in mediating cisplatin resistance ovarian cancer. To further explore the mechanism underlying NRF2‐dependent resistance, stably overexpressed or knocked down parental and cisplatin‐resistant human cancer cells, respectively. These two pairs of stable cell lines were then subjected to microarray analysis, where identified 18 putative target genes. Among these genes, ABCF2 , cytosolic member ABC superfamily transporters, has...
Abstract Aim: Metformin plays an important role in the inhibition of cancer cell growth and prolongs remission durations. It reverses progestin‐resistance endometrial cells by downregulating glyoxalase I (GloI) expression. This study aimed to investigate effect metformin on chemotherapeutic sensitivity explore underlying molecular mechanisms. Material Methods: MTT assay was performed determine rate death after cisplatin paclitaxel with or without metformin. Western blot carried out analyze...
NANOG is a key transcription factor that overexpressed and plays an important role in various cancers. Its overexpression associated with highly tumorigenic, drug-resistant, poor prognosis. However, the underlying mechanism of action ovarian cancer remains unclear. Epithelial-mesenchymal transition (EMT), which critical process invasion metastasis, also drug resistance. We determined whether EMT chemoresistance epithelial cells. expression was increased cells (HEY SKOV3) compared normal...
Abstract Persistent unopposed estrogen stimulation is a central oncogenic mechanism driving the formation of type I endometrial cancer. Recent epidemiologic and clinical studies cancer have also revealed role for insulin resistance, clinically manifested by chronic inflammation. However, inflammation in estrogen-driven not well characterized. In this study, we investigated association between infiltrating macrophages sensitivity Evaluating tissue samples serum from patients with precancerous...
Induction of Nuclear factor erythroid 2 (NF-E2)-related (Nrf2) has been demonstrated to be involved in cisplatin resistance ovarian cancer. Solute carrier family 40 member 1 (SLC40A1) is an iron exporter, which possesses many putative Nrf2 binding sites. Here we hypothesize that it may a possible downstream gene Nrf2. Elevated level and reduced SLC40A1 were found cisplatin-resistant cancer cells as compared with cisplatin-sensitive cells. Exogenous knockdown leaded increased expression...
Numerous genes have been associated with multiple morphological abnormalities of the sperm flagella (MMAF), which cause severe asthenozoospermia and lead to male infertility, while causes approximately 50% MMAF cases remain unclear. To reveal genetic in an infertile patient, whole-exome sequencing was performed screen for pathogenic genes, electron microscope used flagellar ultrastructure. A novel heterozygous missense mutation outer dense fiber protein 2 (ODF2) gene detected, inherited from...
Progestin resistance is the main obstacle to successful conservative therapy in young endometrial cancer patients. To investigate molecular events that lead progestin and find a possible way reverse cancer, we established progestin-resistant Ishikawa cell line by long-term treatment downregulate progesterone receptor (PR) expression. Both medoxyprogesterone acetate (MPA) LY294002, phosphatidylinositol 3-kinase (PI3K) inhibitor, were assayed for their effects on proliferation of...
Introduction: A long-term treatment with progestin commonly results in resistance endometrial cancer. So, the aim of this study was to investigate role glyoxalase I (GloI), a mediator chemotherapy resistance, metformin reversal carcinoma. Methods: The proliferation variety cancer cells determined by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-Diphenyltetrazolium (MTT) assay after exposure medroxyprogesterone acetate, metformin, or both reagents; apoptosis rates were assessed flow cytometry. Real-time...
Objective: To compare the efficacy of metformin plus megestrol acetate (MA) with that MA alone for treating endometrial atypical hyperplasia (EAH).Methods: This pilot study included 16 EAH patients who met at least one metabolic syndrome (MS) criterion and received either adjunctive (MET group) or monotherapy (MA group).Each patient in group 160 mg daily, whereas MET same dose 0.5 g thrice daily.Treatment response was assessed by histological examination dilation curettage specimens obtained...
Abstract Golgi phosphoprotein 3 ( GOLPH ), a newly recognized oncogene, is associated with tumor growth, metastasis, and poor prognosis in several types of cancer. However, its biological role underlying mechanism epithelial ovarian cancer EOC ) remain poorly understood. Here, we found that was overexpressed tissues cell lines. This overexpression promoted the migration invasion cells. Moreover, upregulated expression epithelial–mesenchymal transition EMT markers, such as N‐cadherin Snail ,...
Ovarian cancer is the leading cause of death among gynecologic cancers and fifth all cancer-related deaths women. The development novel molecular targets therefore important to many patients. Recently, SRY-related transcription factor SOX2 has been widely reported be involved in multiple pathophysiological diseases, including maintenance stem cell characteristics carcinogenesis. Up now, mainly shown promote cancer, although its inhibitory roles have also reported. However, role ovarian...
Aberrant expression of ETS transcription factors characterizes numerous human malignancies. Many these proteins, including EWS::FLI1 and EWS::ERG fusions in Ewing sarcoma (EwS) TMPRSS2::ERG prostate cancer (PCa), drive oncogenic programs via binding to GGAA repeats. We report here that both ERG bind transcriptionally activate GGAA-rich pericentromeric heterochromatin. The respective pathogen-like HSAT2 HSAT3 RNAs, together with LINE, SINE, ERV other repeat transcripts, are expressed EwS PCa...
ABSTRACT Embryo morphology assessment is crucial for determining embryo viability in assisted reproductive technology. Traditional manual evaluation, while currently the primary method, time‐consuming, resource‐intensive, and prone to inconsistencies due complex analysis of morphological parameters such as cell shape, size, blastomere count. For rapid accurate recognition quantification blastomeres images, Attention Gated‐RetinaNet (AG‐RetinaNet) model proposed this article. AG‐RetinaNet...
OCT4, a stem cell marker, is overexpressed in several types of human cancer and can induce resistance to chemotherapy inhibition apoptosis. We previously demonstrated that follicle stimulating hormone (FSH) inhibit ovarian However, the role OCT4 FSH-induced apoptosis has not been reported detail. Here, we profiled protein expression epithelial (OEC) with benign cystadenoma, borderline tumor carcinoma tissues as well different lines normal cells. Furthermore, effects FSH on related signaling...