A5064376023- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Ovarian cancer diagnosis and treatment
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- RNA Research and Splicing
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Immune cells in cancer
- Glutathione Transferases and Polymorphisms
- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
Shanghai University of Medicine and Health Sciences
2019-2024
Computer Emergency Response Team
2019
Obstetrics and Gynecology Hospital of Fudan University
2017-2019
Shanghai Medical College of Fudan University
2017-2019
Previously, we have demonstrated that NRF2 plays a key role in mediating cisplatin resistance ovarian cancer. To further explore the mechanism underlying NRF2‐dependent resistance, stably overexpressed or knocked down parental and cisplatin‐resistant human cancer cells, respectively. These two pairs of stable cell lines were then subjected to microarray analysis, where identified 18 putative target genes. Among these genes, ABCF2 , cytosolic member ABC superfamily transporters, has...
Induction of Nuclear factor erythroid 2 (NF-E2)-related (Nrf2) has been demonstrated to be involved in cisplatin resistance ovarian cancer. Solute carrier family 40 member 1 (SLC40A1) is an iron exporter, which possesses many putative Nrf2 binding sites. Here we hypothesize that it may a possible downstream gene Nrf2. Elevated level and reduced SLC40A1 were found cisplatin-resistant cancer cells as compared with cisplatin-sensitive cells. Exogenous knockdown leaded increased expression...
Abstract Aim Patient‐derived xenograft (PDX) model has been applied to the study of breast cancer, lung colon cancer and other cancers. However, its feasibility in ovarian not understood. This aimed establish PDX reveal influence factors. Methods In this study, 27 patients Obstetrics Gynecology Hospital affiliated Fudan University from May 2015 2016 were employed explore method verify feasibility. Results Finally, five cases models successfully established, tumor formation rate (TFR) was...
Introduction Hydrometra is a common gynecological disease, especially in postmenopausal women. However, its epidemiology, harmfulness, and value predicting tumors have not been clearly elucidated. Methods In this study, the prevalence rate of risk factors for hydrometra were investigated 3,903 women who underwent screening diseases at Zhoupu Hospital Shanghai from 1 January to 31 December 2021. addition, pathological distribution predictive studied another 186 patients whom was diagnosed...