A5043396070- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Extracellular vesicles in disease
- Kruppel-like factors research
- Cancer Mechanisms and Therapy
- Cervical Cancer and HPV Research
- TGF-β signaling in diseases
- Wnt/β-catenin signaling in development and cancer
- Viral-associated cancers and disorders
- Lung Cancer Research Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ubiquitin and proteasome pathways
- Pluripotent Stem Cells Research
- Cardiovascular Disease and Adiposity
- PI3K/AKT/mTOR signaling in cancer
- Galectins and Cancer Biology
Technical University of Munich
2024
Shanghai Jiao Tong University
2012-2024
Shanghai First People's Hospital
2012-2023
Shanghai Medical College of Fudan University
2017
Nanjing Medical University
2017
// Jing Zhang 1, * , Lei Liu 2, Yunyan Sun 1 Jiandong Xiang Dongmei Zhou Li Wang Huali Xu Xiaoming Yang Na Du Meng 3 Qin Yan Xiaowei Xi Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, China 2 Ren Ji School Medicine, University, Pathology, Fudan Cancer Center, These authors contributed equally to this work Correspondence to: Xi, e-mail: xixiaowei1966@126.com Yan, yanqin76@126.com Keywords: miR-520g, epithelial ovarian...
Abstract Among the gynaecological cancers, epithelial ovarian cancer (EOC) has highest lethality because of high incidence tumour progression and metastasis. Exploration detailed mechanisms underlying EOC metastasis identification crucial targets is important to better estimate prognosis improve treatment this disease. The present study aimed identify role miR-520h in patients with EOC, its involvement progression. We showed that was upregulated 116 especially those advanced-stage disease,...
Ovarian cancer is one of the most common cancers which cause female mortality. The knowledge ovarian initiation and progression critical to develop new therapeutic strategies treat prevent it. Recently, SOX3 has been reported play a pivotal role in tumor progression. However, clinical significance human remains elusive, identity initiation, progression, related underlying mechanism unknown. In this study, we showed that expression increased from benign borderline malignant tumors....
The relationship between endometrial carcinoma and cellular metabolism is unknown. In cancer, mutation rate of PTEN has been reported very high. Malate dehydrogenase 2 (MDH2) one the isoforms malate dehydrogenase, which involved in citric acid cycle mitochondria. Our study aimed to investigate role MDH2 played PTEN-regulated carcinoma.To reveal expression co-localization MDH2, immunohistochemistry immunofluorescent staining were used. Western blot, Real-time PCR, RNA interference...
Increasing evidence shows that the calpain regulatory subunit Capn4 can modulate proliferation and metastasis of cancer cells, plays an important role in development malignant tumors. However, there is no information on clinical significance epithelial ovarian carcinoma (EOC) or molecular mechanisms by which promotes growth EOC. Therefore, aim this study was to clarify EOC.We evaluated osteopontin (OPN) expression EOC cell lines tissues from patients with western blotting immunohistochemical...
This study was conducted to evaluate the prognostic value of receptor-interacting protein kinase 4 (RIPK4) in ovarian cancer (OC) and its role tumorigenesis. RNA expression corresponding clinical data were obtained from The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases. relationship between clinical-pathological characteristics RIPK4 analyzed using Wilcoxon signed-rank test logistic regression. Cox regression Kaplan-Meier method used clinicopathological features...
Background.Dendritic cells (DCs) are a key class of immune that migrate to the draining lymph nodes and present processed antigenic peptides lymphocytes after being activated by external stimuli, thereby establishing adaptive immunity.Moreover, DCs play an important role in tumor immunity.Objectives.The aim study was investigate whether MCT1 gene silencing affects their ability mount response against cervical cancer cells. Materials methods.We silenced expression from mouse bone marrow (BM)...
Ovarian cancer (OC) is one of the common malignant tumors that seriously threaten women's health, and there a lack clinical prognostic predictors, while m5c lncRNA have been shown to be predictive multiple cancers, including OC. Therefore, our goal was construct risk model for OC based on m5c-related lncRNA.340 were identified novel ground nine m5C-related constructed using LASSO-COX regression analysis. Kaplan-Meier analysis showed significant difference in prognosis between groups. We...
Cervical cancer is one of the most common cancers worldwide, and immune function may impact disease progression. Serum markers also be associated with diagnosis The aim this study was to explore clinical usefulness determining levels peripheral blood cells serum tumor in predicting prognosis patients cervical cancer.82 (early stage group: IA-IB1 IIA1; locally advanced IB2 IIA2), 54 intra-epithelial neoplasia (CIN), healthy women (control group) were recruited. Inclusion criteria were: (1)...
Background: RNA methylation is a significant form of post-transcriptional modification that has been implicated in various diseases, including cancers. One prominent type 5-Methylcytosine (m5C), which primarily regulates stability, transcription, and translation. However, the role m5C-related gene regulation cell adhesion within uterine corpus endometrial carcinoma (UCEC) remains unexplored. Therefore, objective this study was to investigate association between m5C UCEC develop prognostic...
G protein-coupled receptor 30 ( GPR30),a sort of novel functional estrogen transmembrane receptor,extensively participate in the pathological and physiological regulation by mediating rapid nongenomic effects estrogen,which plays an important role occurrence development hormone-related malignant neoplasms. Key words: Estrogens; Breast neoplasms; Endometrial neoplasms; Ovarian neoplasms; GPR30