A5053231452- Galectins and Cancer Biology
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Viral Infections and Vectors
- Inflammatory Biomarkers in Disease Prognosis
- Multiple Myeloma Research and Treatments
- Cancer, Lipids, and Metabolism
- Esophageal Cancer Research and Treatment
- Wnt/β-catenin signaling in development and cancer
- Cancer Mechanisms and Therapy
Qilu Hospital of Shandong University
2023-2024
Shanghai First People's Hospital
2021
Shanghai Jiao Tong University
2021
Second Affiliated Hospital of Nanchang University
2018
Nanchang University
2018
Chemotherapy resistance in ovarian cancer hampers cure rates, with cancer-associated fibroblasts (CAFs) playing a pivotal role. Despite their known impact on progression and chemotherapy resistance, the specific mechanism by which CAFs regulate tumor inflammatory environment remains unclear. This study reveals that cisplatin facilitates DNA transfer from cells to CAFs, activating CGAS-STING-IFNB1 pathway promoting IFNB1 release. Consequently, this reinforces cell platinum drugs. High STING...
This study was conducted to evaluate the prognostic value of receptor-interacting protein kinase 4 (RIPK4) in ovarian cancer (OC) and its role tumorigenesis. RNA expression corresponding clinical data were obtained from The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases. relationship between clinical-pathological characteristics RIPK4 analyzed using Wilcoxon signed-rank test logistic regression. Cox regression Kaplan-Meier method used clinicopathological features...
Multiple myeloma (MM) is a malignant disease characterized by single clonal proliferation of B cell-derived plasma cells in the bone marrow. It second most common haematologic malignancy adults. The objective this retrospective study to evaluate diagnostic and prognostic value parameters MM.The difference NLR/ALB ratio (NAR) NLR/HDL-C (NHR) between 151 newly diagnosed MM patients 153 healthy controls was compared. According NAR NHR cutoff values obtained from ROC curve, were divided into low...