A5100767555- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Ion channel regulation and function
- Viral Infectious Diseases and Gene Expression in Insects
- Viral Infections and Vectors
- Genomics and Chromatin Dynamics
- Cellular transport and secretion
- Mosquito-borne diseases and control
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
- Pancreatic function and diabetes
- Chromosomal and Genetic Variations
- Bird parasitology and diseases
- Heat shock proteins research
- Growth Hormone and Insulin-like Growth Factors
- Plant Ecology and Soil Science
- GABA and Rice Research
- Lysosomal Storage Disorders Research
University of Oslo
2021-2025
Nanjing Agricultural University
2024
Liaoning Vocational College of Medical
2020-2024
Chinese Academy of Sciences
2004-2023
Wuhan Institute of Virology
2020-2023
University of Chinese Academy of Sciences
2012-2023
Shaanxi Provincial People's Hospital
2023
First Affiliated Hospital of Kunming Medical University
2022
Kunming Medical University
2022
Oslo University Hospital
2018-2022
We have produced a draft sequence of the rice genome for most widely cultivated subspecies in China, Oryza sativa L. ssp. indica , by whole-genome shotgun sequencing. The was 466 megabases size, with an estimated 46,022 to 55,615 genes. Functional coverage assembled sequences 92.0%. About 42.2% exact 20-nucleotide oligomer repeats, and transposons were intergenic regions between Although 80.6% predicted Arabidopsis thaliana genes had homolog rice, only 49.4% A. . large proportion no...
The methyltransferase like 3 (METTL3)-containing complex catalyzes the N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; however, nature of this remains largely unknown. Here we report two new components human m6A complex, Wilms' tumor 1-associating protein (WTAP) and 14 (METTL14). WTAP interacts with METTL3 METTL14, is required for their localization into nuclear speckles enriched pre-mRNA processing factors catalytic activity in vivo. majority RNAs bound by vivo...
The role of Fat Mass and Obesity-associated protein (FTO) its substrate N6-methyladenosine (m6A) in mRNA processing adipogenesis remains largely unknown. We show that FTO expression m6A levels are inversely correlated during adipogenesis. depletion blocks differentiation only catalytically active restores Transcriptome analyses combination with m6A-seq revealed gene splicing grouped genes regulated by FTO. M6A is enriched exonic regions flanking 5′- 3′-splice sites, spatially overlapping...
N 6 -methyladenosine (m6A) modification in mRNAs was recently shown to be dynamically regulated, indicating a pivotal role multiple developmental processes. Most recently, it that the Mettl3-Mettl14 writer complex of this mark is required for temporal control cortical neurogenesis. The m6A reader protein Ythdf2 promotes mRNA degradation by recognizing and recruiting decay machinery.We show conditional depletion mice causes lethality at late embryonic stages, with embryos characterized...
Non-receptor protein tyrosine phosphatases (PTPNs) are a set of enzymes involved in the tyrosyl phosphorylation. The present study intended to clarify associations between expression patterns PTPN family members, and diagnosis as well prognosis digestive tract cancers.Oncomine Ualcan were used analyze expressions. Data from Cancer Genome Atlas (TCGA) downloaded through UCSC Xena for validation explore relationship with diagnosis, clinicopathological parameters survival cancers. Gene ontology...
Mitotic entry correlates with the condensation of chromosomes, changes in histone modifications, exclusion transcription factors from DNA, and broad downregulation transcription. However, whether mitotic influences subsequent interphase is unknown. Here, we show that preventing one chromosome to condense during mitosis causes it fail resetting Rather, following interphase, affected contains unusually high levels machinery, resulting abnormally expression genes cis , including various...
Post-translational modification by the small ubiquitin-like modifier (SUMO) is essential for cellular differentiation and homeostasis. Here, we investigate role of SUMOylation in adipose tissue development using TAK-981, a pharmacological inhibitor SUMOylation. Administration TAK-981 to mice resulted significant defect weight gain adipocyte atrophy perigonadal white (gWAT) depots. Gene expression analyses revealed marked downregulation adipogenic genes, including Pparg, Cebpa, Fasn. Our data...
Bunyavirus ribonucleoprotein (RNP) that is assembled by polymerized nucleoproteins (N) coating a viral RNA and associating with polymerase can be both the synthesis machinery structural core of virions. Bunyaviral N RNP thus could assailable targets for host antiviral defense; however, it remains unclear which how factors target N/RNP to restrict bunyaviral infection. By mass spectrometry protein-interaction analyses, we here show protein MOV10 proteins encoded group emerging high-pathogenic...
Aim: To explore the expression profiles of N6-methyladenosine (m6A) enzymes (writers, erasers and readers) their associations with gastric cancer (GC) prognosis. Methods: Gene was analyzed using UALCAN Oncomine web resources. The prognostic roles these genes in GC were data from Cancer Genome Atlas. Results: Thirteen m6A found to be upregulated tissues. writers METTL3, RBM15 WTAP associated pathological stage. eraser FTO related tumor stage ALKBH5 reader YTHDF3 YTHDC2 survival patients....
Tight control of gene expression networks required for adipose tissue formation and plasticity is essential adaptation to energy needs environmental cues. However, the mechanisms that orchestrate global dramatic transcriptional changes leading adipocyte differentiation remain be fully unraveled. We investigated regulation nascent transcription by sumoylation pathway during using SLAMseq ChIPseq. discovered has a dual function in differentiation; it supports initial downregulation...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease high case mortality rates, which caused by Dabie bandavirus (DBV), a novel pathogen also termed as SFTS virus (SFTSV). Currently, no specific therapeutic drugs or vaccines are available for SFTS. Myxovirus resistance protein A (MxA) has been shown to inhibit multiple viral pathogens; however, the role of MxA in DBV infection unknown. Here, we demonstrated that stimulates expression which, turn, restricts...
In adipocytes and cardiac or skeletal muscle, glucose transporter isoform 4 (GLUT4) is targeted to insulin-responsive intracellular membrane vesicles (IRVs) that contain several proteins, including aminopeptidase (IRAP) completely colocalizes with GLUT4 in basal insulin-treated cells. Cardiac content reduced by 65-85% IRAP knockout mice, suggesting may regulate the targeting degradation of GLUT4. To determine whether required for maintenance within IRVs, we studied expression cellular...
Phosphoinositides now emerge as important regulators of membrane traffic. In particular, phosphatidylinositol 4-phosphate may serve a precursor for polyphosphorylated derivatives and, also, regulate vesicular traffic by recruiting specific proteins to the membrane. Early results have demonstrated presence 4-kinase (PI4K) activity in glucose transporter 4 (Glut4) vesicles from fat and skeletal muscle cells. However, molecular identity 4-kinase(s) associated with Glut4 has not been...
Background: 5-methylcytosine (m5C) RNA methylation plays a significant role in several human diseases. However, the functional of m5C type 2 diabetes (T2D) remains unclear. Methods: The merged gene expression profiles from two Gene Expression Omnibus (GEO) datasets were used to identify m5C-related genes and T2D-related differentially expressed (DEGs). Least-absolute shrinkage selection operator (LASSO) regression analysis was performed optimal predictors T2D. After LASSO regression, we...