Indirect evidence suggests that excitatory amino acids (EAA) are involved in synaptic transmission of visceral afferents at their synapses within the nucleus tractus solitarius (NTS). Little is known about identity postsynaptic receptors or response mechanisms. Here we report results from a longitudinal brain slice rat medulla. Intracellular recordings were made neurons delimited portions dorsal medial NTS (mNTS) to receive baroreceptor inputs. Stimulation solitary tract 1-3 mm mNTS...

Thermal dilation is a vital component of deformation along the extensive railway network infrastructure. To monitor subtle deformation, synthetic aperture radar interferometry (InSAR) technique has been adopted as space-borne geodetic tool. However, InSAR applications in stability surveillance have largely limited by sparseness detectable point-like targets (PTs). Moreover, only one-dimensional linear displacements line-of-sight direction can be measured single data stack. address these...

Large-scale reclamation projects during the past decades have been recognized as one of driving factors behind land subsidence in coastal areas. However, pattern temporal evolution settlements has rarely analyzed. In this work, we study spatio-temporal Linggang New City (LNC) Shanghai, China, using space-borne synthetic aperture radar interferometry (InSAR) methods. Three data stacks including 11 X-band TerraSAR-X, 20 L-band ALOS PALSAR, and 35 C-band ENVISAT ASAR images were used to...

Abstract A deeper understanding of the underlying biological mechanisms secondary brain injury induced by traumatic (TBI) will greatly advance development effective treatments for patients with TBI. Hypoxia-inducible factor-1 alpha (HIF-1α) is a central regulator cellular response to hypoxia. In addition, growing evidence shows that HIF-1α plays important role in TBI-induced changes processes; however, detailed functional are not completely known. The aim present work was further explore...

As a city undergoes large-scale construction and expansion, there is an urgent need to monitor the stability of ground infrastructure. The time-series InSAR technique effective tool for measuring surface displacements. However, interpreting these displacements in built environment, where observed consist mixed signals, poses challenge. This study uses principal component analysis (PCA) k-means clustering method exploring deformation series within unsupervised learning context. PCA extracts...

The Open-Source Digital Elevation Model (DEM) is fundamental data of the geoscientific community. However, variation its accuracy with land cover type and topography has not been thoroughly studied. This study evaluates five globally covered open-accessed DEM products (TanDEM-X90 m, SRTEM, NASADEM, ASTER GDEM, AW3D30) in mountain area using ICESat/GLAS as GCPs. robust evaluation indicators were utilized to compare DEMs’ explore relationship between these errors slope, aspect, landcover...

The metro system solves traffic congestion in urban transportation while bringing potential deformation risks, especially tunnels built typical soft deposits coastal cities. Time-series Synthetic Aperture Radar Interferometry (TS-InSAR) is an effective tool for monitoring land subsidence areas. However, the different structures of lines, such as elevated tracks, ground and tunnels, were often neglected previous studies. Here, we introduced a Station Based Monitoring (SBM) method combined...

Abstract Aims To investigate astrocyte‐related phagocytosis of synapses in the ipsilateral hippocampus after traumatic brain injury (TBI). Methods We performed controlled cortical impact to simulate TBI mice. Seven days postinjury, we cognitive tests, synapse quantification, and examination astrocytic association with Megf10 expression. Results During subacute stage post‐TBI, found a reduction excitatory postsynaptic materials hippocampus, which was consistent poor performance test. The...

The fluctuation of energy price and the expensive cost during peak period will affect living users, transmission congestion also bring additional costs. To solve this problem, paper establishes demand response model users. Users can obtain a lower by adjusting their replaceable load load. This uses cooperative game pricing method to problem allocation. In order ensure privacy independence system, alternating direction multipliers is proposed decouple integrated system. verified in system...

Repetitive mild traumatic brain injury (rmTBI) can lead to somatic, emotional, and cognitive symptoms that persist for years after the initial injury. Although ability of various treatments promote recovery rmTBI has been explored, optimal time window early intervention is unclear. Previous research shown hydrogen-rich water (HRW) diffuse through blood-brain - barrier, attenuate local oxidative stress, reduce neuronal apoptosis in patients with severe However, on effect HRW scarce.

Aims: To isolate a bacterium that produces high yield of melanin and to examine the effect this bacterial pigment on efficacy bioinsecticide. Methods Results: A novel melanin-producing bacterium, designated as strain WS, was isolated from East Lake, Wuhan, China. Taxonomic studies indicate it belongs Aeromonas media. Physicochemical analysis produced by WS (melanin WS) suggests is authentic 3,4-dihydroxyphenylalanine (DOPA)-melanin. This Pseudomonas maltophilia P28 P28) share many...

The balance of mineralocorticoid receptor (MR) and glucocorticoid (GR) is indispensable for maintaining the normal function structure hippocampus. However, changes in GR/MR their effect on survival hippocampal neurons after traumatic brain injury (TBI) are still unclear. Previous studies have indicated that high-dose glucocorticoids (GC) aggravate neuronal damage TBI. We hypothesize imbalance expression activation caused by irrational use dexamethasone (DEX) aggravates post-traumatic...

Introduction Type 2 diabetes (T2D) is a common chronic heterogeneous metabolic disorder. However, the roles of pyroptosis and infiltrating immune cells in islet dysfunction patients with T2D have yet to be explored. In this study, we aimed explore potential crucial genes pathways associated infiltration T2D. Methods To achieve this, performed conjoint analysis three bulk RNA-seq datasets islets identify T2D-related differentially expressed (DEGs). After grouping samples according their...

Multi-temporal Interferometric Synthetic Aperture Radar technique (MTInSAR) has emerged as a valuable tool for measuring ground motion in wide area. However, interpreting displacement time series and identifying dangerous signals from millions of InSAR coherent targets is challenging. In this study, we propose method combining stacked autoencoder (SAE) convolutional neural network (CNN) to classify ease the interpretation movements. The are classified into five categories, including stable,...

Acting as economic lifelines, bridges are essential infrastructure elements in China. The continuous monitoring of their stability therefore is utmost significance to prevent the public death and injures resulting from bridge collapses. Typically, deformation detected by traditional on-structure surveying methods which limited sparse measurements large consumption time manpower. Thanks availability numerous archived high-resolution spaceborne synthetic aperture radar (SAR) images coupled...

Since the Persistent Scatterer Synthetic Aperture Radar (SAR) Interferometry (PSI) technology allows detection of ground subsidence with millimeter accuracy, it is becoming one most powerful and economical means for health diagnosis major transportation infrastructures. However, structures different types may suffer from various levels localized due to structural characteristics mechanisms. Moreover, in complex urban scenery, some segments these infrastructures be sheltered by surrounding...

Land subsidence can be observed with time-series of Interferometric Synthetic Aperture Radar (InSAR) data. However, existing approaches only reveal signals that are multi-scale mixed, which is not conducive to the systematic analysis different mechanisms. A deformation signal decomposition (DSD) method based on spectral used decompose extracted by InSAR into three classes signals. They refer large-scale related geological settings, medium-scale caused more group excavation, and small-scale...