A5014288482- Environmental Toxicology and Ecotoxicology
- Pharmaceutical and Antibiotic Environmental Impacts
- Aquaculture disease management and microbiota
- MicroRNA in disease regulation
- Zebrafish Biomedical Research Applications
- Reproductive biology and impacts on aquatic species
- Fish Biology and Ecology Studies
- Toxic Organic Pollutants Impact
- Insect and Pesticide Research
- Neuroendocrine regulation and behavior
- Aquaculture Nutrition and Growth
- Fish Ecology and Management Studies
- Effects and risks of endocrine disrupting chemicals
- Insect Pest Control Strategies
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Carcinogens and Genotoxicity Assessment
- Chemistry and Chemical Engineering
- Animal testing and alternatives
- Neuropeptides and Animal Physiology
- Genomics, phytochemicals, and oxidative stress
- Neuroscience and Neuropharmacology Research
- Invertebrate Immune Response Mechanisms
- Adipose Tissue and Metabolism
- Memory and Neural Mechanisms
Research Center for Eco-Environmental Sciences
2016-2025
Chinese Academy of Sciences
2016-2025
University of Chinese Academy of Sciences
2017-2021
Huazhong Agricultural University
2016-2017
As potential substitutes for polybrominated diphenyl ethers (PBDEs), organophosphate flame retardants (OPFRs) have been frequently detected in the environment. However, genotoxicity induced by these OPFRs has rarely described, and results reported previous studies are conflicting inconsistent. The present study aimed to determine how genetic toxicity vivo. Using Chinese rare minnow as a model, of three was screened with RNA-seq. To verify OPFR-induced genotoxicity, alkaline comet assay, cell...
The neurotoxicity of triphenyl phosphate (TPHP) in exposed humans and laboratory animals is under debate. rapid crossing the blood-brain barrier (BBB) high distribution TPHP fish brains have raised widespread concerns about potential neurotoxicity. Adult male Chinese rare minnows (Gobiocypris rarus) were used as a model to 0, 20, or 100 μg/L for 28 days. We evaluated BBB permeability, neuroinflammatory response, cell proliferation apoptosis, synaptic plasticity synapse loss via...
Residual antidepressants are of increasing concern worldwide, yet critical information on their long-term neurotoxic impacts nontarget aquatic animals is lacking. Here, we investigated the effects (from 0 to 150 days postfertilization) selective serotonin reuptake inhibitor citalopram (0.1–100 μg/L) motor function, learning, and memory in zebrafish over two generations explored reversibility effect F1 larvae. Unlike F0+ larvae, found that F1+ larvae displayed decreased sensorimotor...
Phenanthrene (Phe) is one of the most abundant low-molecular-weight polycyclic aromatic hydrocarbons (PAHs). Widespread human and aquatic organism exposure to Phe has been reported, but toxic effects potential mechanisms are unclear. We focused on chronic hepatotoxicity in adult Chinese rare minnows (Gobiocypris rarus) underlying mechanisms. The exposing 8.9, 82.3, or 510.0 μg/L for 30 days were examined by histopathological observation, TUNEL assays, caspase activity gene expression...
MicroRNAs (miRNAs), which comprise a large family of endogenous small non-coding RNA molecules, play important roles in the regulation gene expression various biological processes. The Chinese rare minnow (Gobiocypris rarus) is native fish species and used extensively as an experimental China; however, relevant data, especially miRNA transcriptome have not been well documented. To discover conserved potential novel miRNAs minnows, pool equal amounts obtained from 6 different adult tissues...
Organophosphorus flame retardants (OPFRs) such as triphenyl phosphate (TPHP) and tris(1,3-dichloro-2-propyl) (TDCIPP) were reported to impair cardiac function in fish. However, limited information is available regarding their cardiotoxic mechanisms. Using rare minnow (Gobiocypris rarus) a model, we found that both TPHP TDCIPP exposures decreased heart rate at 96 h postfertilization (hpf) embryos. Atropine (an mAChR antagonist) can significantly attenuate the bradycardia caused by TPHP, but...