A5101863979- Genomics and Phylogenetic Studies
- Identification and Quantification in Food
- Genetic diversity and population structure
- Aquaculture disease management and microbiota
- Cephalopods and Marine Biology
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Civil and Geotechnical Engineering Research
- Aquaculture Nutrition and Growth
- Reproductive biology and impacts on aquatic species
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Endoplasmic Reticulum Stress and Disease
- Asphalt Pavement Performance Evaluation
- Cancer-related gene regulation
- RNA Research and Splicing
- Chemical synthesis and alkaloids
- RNA regulation and disease
- Invertebrate Immune Response Mechanisms
- Genomic variations and chromosomal abnormalities
- Circular RNAs in diseases
- Echinoderm biology and ecology
- Fish Biology and Ecology Studies
- Grouting, Rheology, and Soil Mechanics
- Genetic Associations and Epidemiology
Soochow University
2025
Kunming Medical University
2017-2024
Qingdao National Laboratory for Marine Science and Technology
2019-2024
Chinese Academy of Fishery Sciences
2016-2024
Laoshan Laboratory
2024
First Affiliated Hospital of Kunming Medical University
2017-2024
Affiliated Hospital of Nantong University
2024
Nantong University
2024
Yancheng Second People's Hospital
2024
China Academy of Transportation Sciences
2013-2021
Most genetic variants associated with type 2 diabetes mellitus (T2DM) have been identified through genome-wide association studies (GWASs) in Europeans. The current study reports a GWAS for young-onset T2DM American Indians. Participants were selected from longitudinal conducted Pima Indians and included 278 cases onset before 25 years of age, 295 nondiabetic controls ≥45 267 siblings or controls. Individuals genotyped on ∼1M single nucleotide polymorphism (SNP) array, resulting 453,654 SNPs...
Abstract The Cephalopoda are a group of highly diverse marine species in the phylum Mollusca, which distributed worldwide. They have evolved some vertebrate‐like biological traits and exhibit complicated behavioural repertoires. Thus, they interesting for studying mechanisms evolutionary convergence, innovational functional structures adaptation to active, predatory lifestyle environments. Despite placement significance cephalopods, genomic data on these organisms remain limited. Here, we...
Abstract Background Cancer-associated fibroblasts (CAFs) have significant tumor regulatory functions, and CAFs-derived exosomes (CAFs-Exo) released from CAFs play an important role in the progression of oral squamous cell carcinoma (OSCC). However, a lack comprehensive molecular biological analysis leaves mechanisms CAFs-Exo OSCC unclear. Methods We used platelet derived growth factor-BB (PDGF-BB) to induce transformation human mucosa fibroblast (hOMF) into CAFs, extracted supernatant hOMF....
Abstract Lung cancer, specifically the histological subtype lung adenocarcinoma (LUAD), has highest global occurrence and fatality rate. Extensive research indicated that RNA alterations encompassing m6A, m5C, m1A contribute actively to tumorigenesis, drug resistance, immunotherapy responses in LUAD. Nevertheless, absence of a dependable predictive model based on m6A/m5C/m1A-associated genes hinders accurately predicting prognosis patients diagnosed with In this study, we collected patient...
Background The role of female-specific factors in the occurrence and progression cardiometabolic disease (CMD) across different genetic risks remains incompletely clear. This study aimed to comprehensively assess association with CMD. Methods was a prospective cohort 150 413 female individuals from UK Biobank. this included premature menopause, adverse pregnancy outcomes, early or late menarche, multiparity, infertility, use oral contraceptive hormone therapy autoimmune diseases, weighted...
Abstract Non-alcoholic fatty liver disease (NAFLD) is a common disease, which has no standard treatment available. Panax notoginseng saponines (PNS) have recently been reported to protect against hepatocyte injury induced by ethanol or high fat diet (HFD) in rats. Compound K and ginsenoside Rh1 are the main metabolites of PNS. In this study, we evaluated effects CK on NAFLD. Rats fed HFD showed significant elevations function markers, lipids, glucose tolerance, insulin resistance. Treatment...
Abstract The greenfin horse‐faced filefish, Thamnaconus septentrionalis , is a valuable commercial fish species that widely distributed in the Indo‐West Pacific Ocean. This has characteristic blue–green fins, rough skin and spine‐like first dorsal fin. of conservation concern because its population declined sharply, it an important marine aquaculture China. Genomic resources for filefish are lacking, no reference genome been released. In this study, chromosome‐level T. was constructed using...
Many human diseases and phenotypes are related to RNA expression, levels of which influenced by a wide spectrum genetic exposure-related factors. In large genome-wide study muscle tissue we found that some genes exhibited bimodal distribution in contrast what is usually assumed studies single healthy tissue. As bimodality has classically been considered hallmark control, assessed the prevalence, cause, association this phenomenon with diabetes-related skeletal from 225 Pima Indians using...
Few coding variants in genes associated with type 2 diabetes (T2D) have been identified, and the underlying physiologic mechanisms whereby susceptibility influence T2D risk are often unknown. The objective of this study was to identify variation that increases for via an effect on a pre-diabetic trait.Whole exome sequencing done 177 Pima Indians. Selected (N = 345) were genotyped 555 subjects characterized body fatness, glucose disposal rates during clamp, acute insulin response glucose, 2-h...
Abstract Alopecia areata ( AA ) is a highly prevalent autoimmune disease that attacks the hair follicle and leads to loss can range from small patches complete of scalp body hair. Our previous linkage genome‐wide association studies GWAS generated strong evidence for aetiological contributions inherited genetic variants at different population frequencies, including both rare mutations common polymorphisms. Additionally, we conducted gene expression GE on biopsies 96 patients controls...
Heat shock proteins (HSPs) are a class of highly conserved that play an important role in biological responses to various environmental stresses. The mariculture Thamnaconus septentrionalis, burgeoning aquaculture species China, frequently encounters stressors such as extreme temperatures, salinity variations, and elevated ammonia levels. However, systematic identification analysis the HSP70 HSP90 gene families T. septentrionalis remain unexplored. This study conducted first genome-wide 12 4...
<b><i>Background:</i></b> The gene for insulin-degrading enzyme (<i>IDE</i>) represents a strong positional and biologic candidate late-onset Alzheimer disease (LOAD) susceptibility. <i>IDE</i> is located on chromosome 10q23.3 close to region of linkage LOAD. In addition, many studies have identified possible role IDE in the degradation amyloid β-protein intracellular precursor protein (APP) domain released by γ-secretase processing. <b><i>Objective:</i></b> To examine association with AD...
To identify genes that affect body mass index (BMI) in American Indians who are predominately of Pima Indian heritage, we previously completed a genome-wide association study 1120 Indians. That also included follow-up genotyping for 9 SNPs 2133 additional subjects. A comprehensive has subsequently been where 292 were genotyped 3562 subjects, which 128 assessed replication 3238 In the combined subjects (n = 6800), BMI associations two SNPs, rs12882548 and rs11652094, approached significance...
Abstract Objective: A genome‐wide association study (GWAS) was recently completed in 1120 Pima Indians to identify loci that influence BMI. Among the top 100 signals were three variants mapped within lysophosphatidylglycerol acyltransferase 1 ( LPGAT1 ) gene. belongs a large family of acyltransferases, which are involved variety biological processes including pathways regulate energy homeostasis and body weight. Therefore analyzed as candidate gene for obesity Indians. Design Methods:...
OBJECTIVE Prior genome-wide association and exon array expression studies both provided suggestive evidence that apoptosis signal regulating kinase 1 (ASK1) may influence in vivo insulin action Pima Indians. Genetic variants or near ASK1 were analyzed to assess the role of this gene type 2 diabetes. RESEARCH DESIGN AND METHODS Genotypic data from 31 used determine linkage disequilibrium pattern across Eight tag SNPs initially genotyped 3,501 full-heritage Replication for with diabetes was...
Tumor microenvironment (TME) is one of the important factors in tumorigenesis and progression, which tumor-associated macrophages (TAMs) play an role non-small cell lung cancer (NSCLC) progression. However, mechanism TAMs NSCLC progression remains unclear, so this study aimed to investigate find potential therapeutic targets.
The East Asian common octopus (
Macrophages are one of the most important players in tumor microenvironment. But contribution macrophages to lung adenocarcinoma (LUAD) is still controversial. The current study aimed display an immune landscape clarify function and detect prognostic hub genes LUAD. transcriptome data were adopted screen differently expressed (DEGs) Cancer Genome Atlas database (TCGA). cell type identification by estimating relative subsets RNA transcripts (CIBERSORT) algorithm was used reveal landscape....