A5064691010- Healthcare Systems and Reforms
- Healthcare Policy and Management
- Health Systems, Economic Evaluations, Quality of Life
- Global Maternal and Child Health
- Global Health Care Issues
- Health Policy Implementation Science
- Healthcare Quality and Management
- Qualitative Comparative Analysis Research
- Cancer-related molecular mechanisms research
- HIV/AIDS Research and Interventions
- HIV/AIDS Impact and Responses
- Primary Care and Health Outcomes
- Aluminum toxicity and tolerance in plants and animals
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Clinical practice guidelines implementation
- Mobile Health and mHealth Applications
- Plant Gene Expression Analysis
- Health disparities and outcomes
- Patient-Provider Communication in Healthcare
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Bacterial Genetics and Biotechnology
- Microbial Metabolic Engineering and Bioproduction
- Circular RNAs in diseases
Sun Yat-sen University
2018-2025
Sun Yat-sen University Cancer Center
2018-2025
South China Agricultural University
2022-2024
Yale University
2019-2024
Agency for Healthcare Research and Quality
2023-2024
Ministry of Agriculture and Rural Affairs
2024
Yale New Haven Health System
2019-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Xiamen University
2012-2023
Among patients with triple-negative breast cancer (TNBC), distant metastasis is the leading cause of death. Our previous studies have shown that TNBC progression greatly facilitated by circKIF4A, but uncertainty remains regarding its role in brain and molecular mechanism. In this study, we found notable upregulation circKIF4A cell lines metastases. Inhibition impaired ability to proliferate, migrate, metastasis. Luciferase reporter assays confirmed competed for binding miR-637 STAT3 3’ UTR....
Macrophages can be polarized into functional classically activated (M1) or alternatively (M2) phenotype. Tumor-associated macrophages (TAMs) mainly exhibit M2 Previous works determined that up-regulation of enolase 2 (ENO2) in diffuse large B-cell lymphoma (DLBCL) cells promote to an M2-like phenotype, thereby consequently promoting the progression DLBCL. Exosomes are a subset extracellular vesicles, carrying various bioactive molecules, mediate signals transduction and regulate immune...
Background and aim:As non-coding RNAs, circular RNAs (circRNAs) contribute to the progression of malignancies by regulating various biological processes.In prostate cancer, however, there is still a lack understanding regarding potential molecular pathways roles circRNAs.Methods: Loss-off function experiments were performed investigate circRNA in cancer.Western blot, qRT-PCR, IHC assay used examine expression level different genes or circRNAs.Further biology conducted uncover mechanism...
To the Editor: Neoadjuvant chemotherapy (NAC) significantly improves prognosis for patients with breast cancer internal mammary lymph node (IMN) involvement,[1] but locoregional treatment of IMNs including IMN dissection (IMND) and boost irradiation (IMNB) has long been debated,[2] owing to difficulty in surgical approaches cardiopulmonary side effects caused by high-dose radiation.[3] date, is rarely performed; thus, data regarding survival outcome IMND quite limited. In terms radiotherapy...
Abstract Background South Africa is home to 7.7 million people living with HIV and supports the largest antiretroviral therapy (ART) program worldwide. Despite global investment in service delivery parallel challenge of non-communicable diseases (NCDs), there are few examples integrated programs addressing both NCDs through differentiated delivery. In 2014, National Department Health (NDoH) launched Central Chronic Medicines Dispensing Distribution (CCMDD) provide patients who have chronic...
Abstract Background Metabolic disturbance is a hallmark of cancers. Targeting key metabolic pathways and metabolism‐related molecular could be potential therapeutic approach. Uncoupling protein 2 (UCP2) plays pivotal part in the malignancy cancer its capacity to develop resistance pharmaceutical interventions. However, it unclear about mechanism how UCP2 acts tumor growth reprogramming process non‐small cell lung (NSCLC). Methods Here, we conducted qRT‐PCR investigate expression both NSCLC...
Tyrosol is an aromatic compound with great value that widely used in the food and pharmaceutical industry. In this study, we reported a synthetic pathway for converting p-coumaric acid (p-CA) into tyrosol Escherichia coli. We found enzyme cascade comprising ferulic decarboxylase (FDC1) from Saccharomyces cerevisiae, styrene monooxygenase (SMO), oxide isomerase (SOI) Pseudomonas putida, phenylacetaldehyde reductase (PAR) Solanum lycopersicum could efficiently synthesize p-CA conversion rate...
The proteasome inhibitor bortezomib (BTZ) is the first-line therapy for multiple myeloma (MM). BTZ resistance largely limits its clinical application in MM. Interleukin-33 (IL-33) exerts antitumor effects through various mechanisms, including enhancing immunity and promoting apoptosis of cancer cells. Here, synergistic anti-MM effect IL-33 was verified, underlying mechanisms were elucidated. Bioinformatic analysis indicated that expression levels downregulated MM, BTZ-treated MM patients...
Traditional Chinese medicine (TCM) is commonly used alongside Western for stroke management in China. However, there significant variation TCM practice, and the utilisation of evidence-based clinical practice guidelines inadequate. This study aims to evaluate effectiveness three popular frameworks-Consolidated Framework Implementation Research (CFIR), Theoretical Domains (TDF) Normalization Process Theory (NPT)-in improving implementation outcomes integrated guideline management. employs a...
Abstract Background An English version of the Patient Perception Patient-Centeredness (PPPC) scale was recently revised, and it is necessary to test this instrument in different primary care populations. Aim This study aimed assess validity reliability a Chinese PPPC scale. Design A mixed method used study. The Delphi collect qualitative quantitative data address content by calculating Content Validity Index, Ratio, adjusted Kappa, Item Impact Score. Confirmatory factor analysis (CFA)...
Abstract Cadmium (Cd), a heavy metal, is negatively associated with plant growth. AMT (ammonium transporter) genes can confer Cd resistance and enhance nitrogen (N) uptake in soybeans. The potential of to alleviate toxicity by modulating rhizosphere microbiota remains unkonwn. Here, the microbial taxonomic metabolic differences three genotypes, i.e., double knockout overexpression lines wild type, were identified. results showed that GmAMT2.1/2.2 could induce soybean recruit beneficial...
Tobacco taxation and smoke-free workplaces reduce smoking, tobacco-related premature deaths associated out-of-pocket health care expenditures. We examine the distributional consequences of a price increase in tobacco products through an excise tax hike, implementation workplaces, China.We use extended cost-effectiveness analysis (ECEA) to evaluate, across income quintiles male population (the large majority Chinese smokers), averted, change revenues generated, financial risk protection...
FOXP2, a member of the forkhead box P (FOXP) family, has been reported to be important in breast cancer. However, its exact mechanisms and pathways remain unclear.To investigate effect FOXP2 on tumor proliferation metastasis triplenegative cancer (TNBC) study underlying molecular mechanism.We first used qRT-PCR detect expression TNBC cell lines tissues. Then we conducted assays, colony formation transwell assays analyze effects cells. Mouse xenograft model was performed further confirm role...
Increasing the availability of basic healthcare services in low-and middle-income countries is not sufficient to meet Sustainable Development Goal target for child survival high-mortality settings, where utilisation often inconsistent and quality care can be poor. We assessed whether poor sick Malawi associated with low healthcare.
Inequalities in health care services are becoming an increasing concern the world including China. This study measured income-related inequalities of residents Hangzhou China access to general practice and specialist identified socioeconomic factors associated with such inequalities.A cross-sectional questionnaire survey was conducted on 1048 ten urban communities Hangzhou, The percentage frequency respondents visiting (GP) hospital clinics over past four weeks prior were estimated....
Introduction. glucose-regulated protein78 (GRP78) is a stress - induced endoplasmic reticulum chaperone protein. It closely related to the occurrence, development, proliferation, differentiation and drug resistance of breast cancer. However, association clinicopathological features between GRP78 triple negative cancer (TNBC) remain be studied. Material Methods. Clinical pathological characteristics overall survival were analysed retrospectively in 179 surgically resected TNBC...