A5010647539- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Cancer Immunotherapy and Biomarkers
- Infection Control in Healthcare
- Musculoskeletal pain and rehabilitation
- Natural Antidiabetic Agents Studies
- Metabolism, Diabetes, and Cancer
- Vestibular and auditory disorders
- Scoliosis diagnosis and treatment
- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Antibiotics Pharmacokinetics and Efficacy
- Myofascial pain diagnosis and treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Phagocytosis and Immune Regulation
- Music Therapy and Health
- Brain Metastases and Treatment
- Workplace Violence and Bullying
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Sleep and Wakefulness Research
- Atherosclerosis and Cardiovascular Diseases
- Nosocomial Infections in ICU
Chinese University of Hong Kong
2022-2025
University of Hong Kong
2020-2025
Second Hospital of Anhui Medical University
2018-2025
Anhui Medical University
2018-2025
Sun Yat-sen University
2014-2025
The First Affiliated Hospital, Sun Yat-sen University
2020-2025
Yichun University
2023
Museum of Heilongjiang Province
2021
Centre for Policy Studies
2019-2020
Zhejiang University
2019-2020
Distant metastasis remains the major cause of morbidity for breast cancer. Individuals with liver or brain have an extremely poor prognosis and low response rates to anti-PD-1/L1 immune checkpoint therapy compared those at other sites. Therefore, it is urgent investigate underlying mechanism resistance develop more effective immunotherapy strategies these patients. Using single-cell RNA sequencing, a high-resolution map entire tumor ecosystem based on 44 473 cells from cancer metastases...
Abstract Intrinsic and acquired anti-HER2 resistance remains a major hurdle for treating HER2-positive breast cancer. Using genome-wide CRISPR/Cas9 screening in vitro vivo, we identify FGFR4 as an essential gene following treatment. inhibition enhances susceptibility to therapy resistant Mechanistically, m6A-hypomethylation regulated phosphorylates GSK-3β activates β-catenin/TCF4 signaling drive resistance. Notably, suppression of dramatically diminishes glutathione synthesis Fe 2+ efflux...
Abstract The reliability of a handheld myotonometer when used in clinical setting to assess paraspinal muscle mechanical properties is unclear. This study aimed investigate the between-session intra-rater young adults with low back pain (LBP) environment. One assessor recorded lumbar tone and stiffness an outpatient department on two occasions. intraclass correlation coefficient (ICC), standard error measurement (SEM), smallest real difference (SRD) Bland-Altman analysis were conducted...
Carbapenem-resistant Klebsiella pneumoniae (CRKp) poses a major threat to global public health. This study aimed investigate the genomic characteristics and phylogenetic relatedness of colonization infection with CRKp among intensive care unit (ICU) patients. A total 61 isolates, including 29 non-ICU-acquired 32 ICU-acquired strains, were collected by active screening culture from 16 ICUs through multicenter cohort study. Following whole-genome sequencing (WGS), seven sequence types (STs)...
Improper medical waste management threatens public health and the environment. The objective of this study was to investigate practices in different level hospitals. A multicenter conducted 566 hospitals Anhui Province, China. self-designed online questionnaire applied collect hospital's characteristics, amount handling waste, occupational safety measures. average generation rates were 0.62 kg/bed, 0.43 0.46 kg/bed per day tertiary hospitals, secondary primary respectively. Different levels...
Brain metastases challenge cancer treatments with poor prognoses, despite ongoing advancements. Immunotherapy effectively alleviates advanced cancer, exhibiting immense potential to revolutionize brain metastasis management. To identify research priorities that optimize immunotherapies for metastases, 2164 related publications were analyzed. Scientometric visualization via R software, VOSviewer, and CiteSpace showed the interrelationships among literature, institutions, authors, topic areas...
Empirical evidence that demonstrates the relationship between pelvic asymmetry and non-specific chronic low back pain (NCLBP) is currently lacking.To establish reliability of Global Postural System (GPS) in assessing identify association parameters occurrence NCLBP young adults.A cross-sectional, regression study.People who were aged 18 30 diagnosed with recruited. Healthy individuals matched for age, sex, education level recruited as controls. was employed to assess asymmetry. Prior...
To evaluate the diagnostic values of using autoantibodies in sera to a panel eight tumor-associated antigens (TAAs) P53, Koc, P62, C-myc, IMP1, Survivn, P16 and Cyclin B1 full-length recombinant proteins for early detection patients with gastric cardia adenocarcinoma (GCA) high-risk subjects screening. Enzyme-linked immunosorbent assay was used detect against selected TAAs 383 samples from four groups, including 140 normal epithelia (NOR), 76 chronic atrophic gastritis (CAG), 79 dysplasia...
Abstract Healthcare-associated infections (HAIs) are a major worldwide public-health problem, but less data available on the long-term trends of HAIs and antimicrobial use in Eastern China. This study describes prevalence tertiary care teaching hospital Hefei, Anhui, China from 2010 to 2017 based annual point-prevalence surveys. A total 12 505 inpatients were included; 600 recorded 533 patients, with an overall 4.26% frequency 4.80%. No evidence was found for increasing or decreasing trend...
This study describes the detection and tracking of emergency neurosurgical cross-transmission infections with carbapenem-resistant
To develop a sensitive, specific, and rapid approach for the detection Getah virus (GETV), set of primers targeting conserved region E1 gene was created. The TaqMan-based real-time PCR method GETV developed by optimizing reaction conditions. demonstrated excellent specificity, amplification did not occur with causative agents all prevalent swine viral infections (CSFV, PRRSV, PRV, PEDV, PTV, JEV), except GETV. Additionally, upon assessing sensitivity method, minimum limit found to be 5.94...
Abstract GABAergic interneurons are poised with the capacity to shape circuit output via inhibitory gating. How early in development of medial vestibular nucleus (MVN) neurons recruited for feedforward shaping outputs higher centers spatial navigation? The role transmission assembling circuits navigation was explored by neonatal perturbation. Immunohistochemistry and confocal imaging were utilized reveal expression parvalbumin (PV)-expressing MVN their perineuronal nets. Whole-cell...
Lupus nephritis (LN) is one of the major complications systemic lupus erythematosus (SLE). The specific mechanisms pathogenesis, aggravation, and remission processes in LN have not been clarified but great need clinic. Using isobaric tags for relative absolute quantitation (iTRAQ) technology to screen functional proteins mice. Especially under intervention factors lipopolysaccharide (LPS) dexamethasone.Mrl-lps mice were intervened with LPS, dexamethasone, normal saline (NS) using...
Abstract A multicenter study of sharps injuries (SIs) and other blood or body fluid (OBBF) exposures was conducted among 33,156 healthcare workers (HCWs) from 175 hospitals in Anhui, China. In total, 12,178 HCWs (36.7%) had experienced at least 1 SI the previous 12 months 8,116 (24.5%) OBBF exposure during months.
Background Hypervirulent Klebsiella pneumoniae lacking classical virulence factors is uncommon, and the mechanisms of this organism are not understood. Methods Following a retrospective study carbapenem-resistant K. based on core genome multilocus sequence typing (cgMLST), isolates that caused high mortality were investigated with genome-wide association (GWAS), proteome analysis an animal model. Results The sublineage type 11 (ST11) , which belongs to complex 3176 (CT3176) K-locus 47...