A5102490374- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Lanthanide and Transition Metal Complexes
- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Axon Guidance and Neuronal Signaling
- Renal cell carcinoma treatment
- Silicone and Siloxane Chemistry
- Visual Culture and Art Theory
- COVID-19 Pandemic Impacts
- Methane Hydrates and Related Phenomena
- Nuclear Receptors and Signaling
- Pharmaceutical studies and practices
- Polar Research and Ecology
- Immunotherapy and Immune Responses
- COVID-19 diagnosis using AI
- SARS-CoV-2 and COVID-19 Research
- Pharmacogenetics and Drug Metabolism
- PARP inhibition in cancer therapy
- Organoboron and organosilicon chemistry
- Vascular Tumors and Angiosarcomas
- Apelin-related biomedical research
Northwest Institute of Eco-Environment and Resources
2025
University of Chinese Academy of Sciences
2024-2025
Fudan University
2017-2025
State Key Laboratory of Genetic Engineering
2017-2025
Ruijin Hospital
2021-2025
Shanghai Jiao Tong University
2023-2025
Central South University
2020-2023
Xiangya Hospital Central South University
2020-2023
Hua Medicine (China)
2023
Bioscience (China)
2022
Background Diffusion‐weighted imaging (DWI) is a useful technique to detect pancreatic lesion. In DWIs, field‐of‐view optimized and constrained undistorted single‐shot (FOCUS) can improve the spatial resolution multiplexed sensitivity‐encoding (MUSE) gain high signal‐to‐noise ratio (SNR). Based on advantage of FOCUS MUSE, new DWI sequence—named FOCUS‐MUSE (FOCUS combined with MUSE)—was developed delineate pancreas. Purpose To investigate reliability compared FOCUS, MUSE (SS) via systematical...
Objectives: IMP7068 is a potent and selective inhibitor of WEE1 kinase. Following oral administration predominantly metabolized by CYP3A4 in the liver. The major metabolite, IMP7253, also pharmacologically active. Population pharmacokinetic (PK) modeling was conducted to characterize concentration-time profiles IMP7253 patients with advanced solid tumors.Methods: population PK analysis based on data from Phase 1 dose-escalation study (IMP7068-101). dataset contains 1006 1028 quantifiable...
Objectives: Rivoceranib (rivo) is a vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor. Camrelizumab (cam) humanized monoclonal antibody that specifically binds to programmed cell death receptor 1 (PD-1). The combination (combo) of rivo 250 mg once daily (QD) and cam 200 every 2 weeks (Q2W) has shown favorable clinical efficacy for the treatment patients (pts) with advanced hepatocellular carcinoma (HCC) in pivotal Phase 3 study (Study CARES-310). Hepatotoxicity was one...
Abstract Objective Ephrin type‐B receptor 1 (EphB1) is a tyrosine kinase involved in axon guidance, synaptic plasticity, and tumorigenesis. However, the role of EphB1 metabolic regulation obesity remains poorly understood. This study aims to uncover energy metabolism provide insights into underlying mechanisms by which regulates obesity. Methods Two Ephb1 mutations identified from forward genetic screen for obesity‐related loci mice were examined their effects gene expression, metabolism,...
Biomass-containing polysiloxane films that exhibit good optical properties and excellent thermal stability for encapsulation have been developed<italic>via</italic>the Piers–Rubinsztajn reaction Pt-catalysed hydrosilylation.
Identification of additional regulatory factors involved in the onset obesity is important to understand mechanisms underlying this prevailing disease and its associated metabolic disorders develop therapeutic strategies. Through isolation analysis a mutant, we aimed uncover function Ras-GAP gene, Rasal2 (Ras protein activator like 2), development related obtain valuable insights regarding mechanism function.An obesity-based genetic screen was performed identify an insertional mutation that...
Poster Presentation - Session: Learning, Education and Different Speech no. Sun-P-7-3-3, paper ID 986
Macrotrabecular hepatocellular carcinoma (MTHCC) has a poor prognosis and is difficult to diagnose preoperatively. The purpose build validate MRI-based models predict the MTHCC subtype.Two hundred eight patients with confirmed HCC were enrolled. Three (model 1: clinicoradiologic model; model 2: fusion radiomics signature; 3: combined 1 2) built based on their clinical data MR images in training validation cohorts. performance of was assessed using area under curve (AUC). utility estimated by...
Background: The various clinical manifestations of COVID-19 have been reported. However, the differences in presentation between children and adults were unclear. Thus, we aimed to investigate imaging characteristics with by systematically analyzing data derived from some latest literatures. Methods: An extensive search papers was conducted PubMed Chinese medical journal network, relevant selected based on standard requirements. included analyzed for manifestation after quality evaluation...
Abstract We compared the clinical utility of single-shot echo-planar imaging (SS-EPI) using different breathing schemes, readout-segmented EPI and zoomit in repeatability apparent diffusion coefficient (ADC) measurements, cortico-medullary contrast to noise ratio (c-mCNR) image quality. In this institutional review board-approved prospective study, some common clinically applicable diffusion-weighted (b = 50, 400, 800 s/mm 2 ) kidney on 3.0 T MRI were performed 22 volunteers SS-EPI with...
Abstract Background Bone morphogenetic protein type II receptor (BMPR2) gene mutation accounts for 80% of patients with heritable pulmonary artery hypertension (HPAH), and female carriers have significantly higher penetrance rate than males. The inducement HPAH the mechanism sex differential are still elusive. Methods We infected or transfected smooth muscle cells (PASMCs) shBMPR2 lentivirus siBMPR2 to simulate pathologic condition BMPR2 heterozygous treated them progesterone....
This paper reports a complete case of severe acute respiratory distress syndrome (ARDS) caused by coronavirus disease 2019 (COVID-19), who presented with rapid deterioration oxygenation during hospitalization despite escalating high-flow nasal cannulation to invasive mechanical ventilation. After inefficacy lung-protective ventilation, positive end-expiratory pressure (PEEP) titration, prone position, we administered extracorporeal membrane (ECMO) as salvage support ultra-protective...
Background: TQ-B3101 is a novel kinase inhibitor currently in development for the treatment of advanced malignant solid tumor and relapsed or refractory ALK-positive anaplastic large cell lymphoma. Methods: A population pharmacokinetic model was developed using data collected from Phase 1 study 2 to characterize its active metabolite (TQ-B3101M). The final used optimize dosing pediatric patients (6-&lt;18 years) with Results: TQ-B3101M adequately described by 1-compartment first-order...
It is well-known that social phenomena can be reflected in art. In the past research time, there have been some results about Dunhuang murals and gender equality, respectively. However, no such one as combining two meaningful topics together applying them modern society. The aim of this study to analyze trend painted by comparing characteristics a different from Beiliang Dynasty Yuan Dynasty, then compare feminization mural images with changes women's status during 1000 years. After...
Abstract Co-targeting PD-1/PD-L1 and TIGIT/CD226 is being pursued to broaden the efficacy of current immunotherapy. Here we demonstrate that a bispecific antibody (BsAb) targeting PD-L1 TIGIT, HB0036, shows major advantages over combination two parental monoclonal Abs (mAbs). We demonstrated HB0036 co-engages + tumour cells TIGIT T cells, thereby upregulates CD226 on induces greater T-cell proliferative response compared antibodies in vitro . In vivo , recruits amounts tumours but not -...
To predict the treatment response for NPC patients is very important. This study aimed to explore diagnostic performance of 3D APT imaging on predicting patients. A total 40 and 14 healthy volunteers were identified in this study. Result show that MT values have good excellent intra- inter-observer agreement. It significant difference between residual non-residual group. The result suggests pre-treatment can be used with chemoradiotherapy, better than ADC value.