A5032242062- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Wound Healing and Treatments
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Skin and Cellular Biology Research
- Tissue Engineering and Regenerative Medicine
- Peripheral Artery Disease Management
- Organ and Tissue Transplantation Research
- Hair Growth and Disorders
- Silk-based biomaterials and applications
- Angiogenesis and VEGF in Cancer
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
- Dermatology and Skin Diseases
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Biomedical Ethics and Regulation
- Cell Adhesion Molecules Research
- Asthma and respiratory diseases
- Renal and related cancers
Cell Biotech (South Korea)
2018-2023
Seoul National University
2009-2016
Abstract Mesenchymal stem cells (MSCs) have been proven to be therapeutically effective against atopic dermatitis (AD) in preclinical studies. However, the safety and efficacy of MSCs AD not yet investigated a clinical study. To establish human umbilical cord blood-derived (hUCB-MSCs) AD, 34 adult patients with moderate-to-severe were enrolled two phase trials follow-up for 1 month 3 months, respectively. Patients randomly allocated receive low dose (2.5 × 107) or high (5.0 hUCB-MSCs...
Abstract Based on immunomodulatory actions of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs), in vitro or preclinical studies hUCB-MSCs have been conducted extensively rheumatoid arthritis (RA). However, few trials investigated the outcomes hUCB-MSC infusions. The CURE-iv trial was a phase I, uncontrolled, open label for RA patients with moderate disease activity despite treatment methotrexate. received single intravenous infusion 2.5 × 107, 5 1 108 30 minutes, three...
Cellular senescence involves a reduction in adult stem cell self-renewal, and epigenetic regulation of gene expression is one the main underlying mechanisms. Here, we observed that cellular human umbilical cord blood-derived multipotent cells (hUCB-MSCs) caused by inhibition histone deacetylase (HDAC) activity leads to down-regulation high mobility group A2 (HMGA2) and, on contrary, up-regulation p16(INK)⁴(A), p21(CIP)¹(/WAF)¹ p27(KIP)¹. We found let-7a1, let-7d, let-7f1, miR-23a, miR-26a...
Background REX1/ZFP42 is a well-known embryonic stem cell (ESC) marker. However, the role of REX1, itself, relatively unknown because function REX1 has only been reported in differentiation ESCs via STAT signaling pathways. Human mesenchymal cells (hMSCs) isolated from young tissues and cancer express REX1. Methodology/Principal Finding umbilical cord blood-derived MSCs (hUCB-MSCs) adipose tissue-derived (hAD-MSCs) strongly have lower activation status p38 MAPK, but bone marrow-derived...
BACKGROUNDRecessive dystrophic epidermolysis bullosa (RDEB) is an incurable disease that causes severe mucocutaneous fragility due to mutations in COL7A1 (encoding type VII collagen [C7]). In this phase I/IIa trial, we evaluated the safety and possible clinical efficacy of intravenous infusion allogeneic human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) patients with RDEB.METHODSFour adult two pediatric RDEB were treated 3 injections hUCB-MSCs (1 × 106 cells/kg) every 2...
Half of patients with critical limb ischemia (CLI) are ineligible for revascularization at diagnosis. The aim this study was to assess the safety and feasibility intramuscular human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) therapy in CLI due atherosclerosis obliterans (ASO) or thromboangiitis (TAO).A total eight (all male, median age 52 years, range 31∼77) were enrolled phase I trial. All considered further improve CLI. We injected 1×10(7) hUCB-MSCs per single dose...
DNA methyltransferase (DNMT) inhibitors regulate target gene expression through epigenetic modifications and these compounds have primarily been studied for cancer therapy or reprogramming. However, the effect of DNMT on immunomodulatory capacity human mesenchymal stem cells (hMSCs) has not investigated. In present study, we treated hMSCs with 5-azacytidine (5-aza), a inhibitor confirmed that inhibitory effects mononuclear cell proliferation migration toward activated T were increased. To...
ZNF281 is one of the core transcription factors in embryonic stem cells (ESCs) and has activation repression roles ESC genes. A known target molecule Zfp281 (the mouse homologue ZNF281) Nanog. However, NANOG not expressed most human multipotent (hMSCs). Here, we investigated with a gain- loss-of-function study. The knockdown vivo vitro resulted spontaneous osteochondrogenic differentiation reduced proliferation hMSCs, as determined by cell morphology molecular markers. When ZNF281-knockdown...
It has widely been reported that basic fibroblast growth factor (bFGF) promotes proliferation of human stem cells and contributes to the maintenance their self-renewal capability through repeated replications. In contrast embryonic (ESCs), effects factors on adult are poorly understood.In umbilical cord blood-derived multipotent (hUCB-MSCs), bFGF is associated with an increased number proliferating cells. Furthermore, expression levels ESC markers were after treatment bFGF. also FGFR, which...
Abstract Mesenchymal stem cells (MSCs) are a promising tool for treating immune disorders. However, the effect and mechanism of canine MSCs compared with other commercialized biologics disorders have not been well studied. In this study, we investigated characteristics immunomodulatory effects amnion membrane (cAM)-MSCs. We examined T lymphocytes from activated peripheral blood mononuclear cell (PBMC) proliferation. As result, confirmed that cAM-MSCs suppressed proliferation capacity...